| In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer. | In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.
Dervovic D, Malik AA, Chen ELY, Narimatsu M, Adler N, Afiuni-Zadeh S, Krenbek D, Martinez S, Tsai R, Boucher J, Berman JM, Teng K, Ayyaz A, Lü Y, Mbamalu G, Loganathan SK, Lee J, Zhang L, Guidos C, Wrana J, Valipour A, Roux PP, Reimand J, Jackson HW, Schramek D., Free PMC Article | 06/2/2023 |
| Characterization of promoter and repressor regions that regulate the transcription of the mouse Adam2 gene. | Identification and characterization of promoter and regulatory regions for mouse Adam2 gene expression.
Choi H, Lee B, Jin S, Kwon JT, Kim J, Jeong J, Oh S, Cho BN, Park ZY, Cho C. | 06/22/2013 |
| data indicate that ITGA9-ITGB7 functions as an ADAM binding partner in certain cellular contexts, with implications for mammalian fertilization and integrin function | ADAM2 interactions with mouse eggs and cell lines expressing α4/α9 (ITGA4/ITGA9) integrins: implications for integrin-based adhesion and fertilization.
Desiderio UV, Zhu X, Evans JP., Free PMC Article | 03/12/2011 |
| we report that Adam2 and Adam3 knockout sperm have severely impaired sperm aggregation and that this defect is not restored over time during in vitro cultivation. | Impaired sperm aggregation in Adam2 and Adam3 null mice.
Han C, Kwon JT, Park I, Lee B, Jin S, Choi H, Cho C. | 06/14/2010 |
| ADAM2 contributes to migration from the subventricular zone along the rostral migratory stream, possibly through cell-cell interactions that mediate the rapid migration of the neuroblasts to their endpoint. | ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb.
Murase S, Cho C, White JM, Horwitz AF., Free PMC Article | 01/21/2010 |
| Results suggest that association with ADAM2 is a key element for stability of ADAM3 in epididymal sperm, and the presence of the ADAM2-ADAM3 complex in sperm also suggests a potential role of ADAM2 with ADAM3 in sperm binding to the egg zona pellucida. | Identification of an ADAM2-ADAM3 complex on the surface of mouse testicular germ cells and cauda epididymal sperm.
Nishimura H, Myles DG, Primakoff P. | 01/21/2010 |
| ADAM1a/ADAM2 Fertilin complex has roles in expression of ADAM3 on the cell surface of mouse sperm | Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface.
Nishimura H, Kim E, Nakanishi T, Baba T. | 01/21/2010 |
| ADAM2 is involved in protein trafficking during sperm development | Defects in secretory pathway trafficking during sperm development in Adam2 knockout mice.
Stein KK, Go JC, Primakoff P, Myles DG. | 01/21/2010 |
| Because fertilin beta is absent from calmegin-deficient mice, the role of fertilin beta in sperm-EPM interaction needs to be reevaluated. | Sperm from the calmegin-deficient mouse have normal abilities for binding and fusion to the egg plasma membrane.
Yamagata K, Nakanishi T, Ikawa M, Yamaguchi R, Moss SB, Okabe M. | 01/21/2010 |
| These results suggest that mouse ADAM1b/ADAM2 fertilin may play a crucial role not in the sperm/egg fusion but in the appearance of these two ADAMs on the sperm surface. | Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization.
Kim E, Yamashita M, Nakanishi T, Park KE, Kimura M, Kashiwabara S, Baba T. | 01/21/2010 |
| role of CD9 in the strengthening of fertilin beta-mediated cell adhesion | Analysis of the roles of RGD-binding integrins, alpha(4)/alpha(9) integrins, alpha(6) integrins, and CD9 in the interaction of the fertilin beta (ADAM2) disintegrin domain with the mouse egg membrane.
Zhu X, Evans JP. | 01/21/2010 |