| FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression. | FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression.
Wu J, Wen T, Marzio A, Song D, Chen S, Yang C, Zhao F, Zhang B, Zhao G, Ferri A, Cheng H, Ma J, Ren H, Chen QY, Yang Y, Qin S., Free PMC Article | 05/22/2024 |
| DNMT1-mediated regulating on FBXO32 promotes the progression of glioma cells through the regulation of SKP1 activity. | DNMT1-mediated regulating on FBXO32 promotes the progression of glioma cells through the regulation of SKP1 activity.
Quan J, Ma C. | 01/11/2024 |
| Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-kappaB/MGMT Axis. | Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-κB/MGMT Axis.
Liao X, Li Z, Zheng H, Qian W, Zhang S, Chen S, Li X, Tang M, Xu Y, Yu R, Li M, Song L, Li J. | 07/7/2023 |
| The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression. | The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression.
Lu Y, Huang P, Li Y, Liu W, Li J, Zhao R, Feng H, Shi C, Cao G., Free PMC Article | 06/23/2023 |
| Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells. | Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells.
Xu K, Liu Q, Huang W, Chu Y, Fan W, Liu J, He Y, Huang F., Free PMC Article | 05/19/2023 |
| A novel likely pathogenic variant in the FBXO32 gene associated with dilated cardiomyopathy according to wholeexome sequencing. | A novel likely pathogenic variant in the FBXO32 gene associated with dilated cardiomyopathy according to whole‑exome sequencing.
Ghasemi S, Mahdavi M, Maleki M, Salahshourifar I, Kalayinia S., Free PMC Article | 11/12/2022 |
| Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 muscle cells. | Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 muscle cells.
Nishimura Y, Chunthorng-Orn J, Lord S, Musa I, Dawson P, Holm L, Lai YC. | 07/16/2022 |
| FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer. | FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer.
Zhang N, Liao Y, Lv W, Zhu S, Qiu Y, Chen N, Xiao M, Zhang H. | 05/7/2022 |
| E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor. | E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor.
García-Valverde A, Rosell J, Sayols S, Gómez-Peregrina D, Pilco-Janeta DF, Olivares-Rivas I, de Álava E, Maurel J, Rubió-Casadevall J, Esteve A, Gut M, Valverde C, Barretina J, Carles J, Demetri GD, Fletcher JA, Arribas J, Serrano C. | 01/8/2022 |
| Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk. | Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk.
Wang H, Liu H, Zhao L, Luo S, Akinyemiju T, Hwang S, Yue Y, Wei Q., Free PMC Article | 11/13/2021 |
| Systematic Review: Models of Changes in Gene Expression of MTOR, MURF-1, and MAFBX in Rats and Mice. | Systematic Review: Models of Changes in Gene Expression of MTOR, MURF-1, and MAFBX in Rats and Mice.
de Macêdo MRC, Marques RF, Silva AJS, Navarro F, Coppi Navarro A. | 07/17/2021 |
| F-box only protein 32 (FBXO32) directly ubiquitinates C-terminal binding protein 1 (CtBP1), which is required for its stability and nuclear retention. | FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development.
Sahu SK, Tiwari N, Pataskar A, Zhuang Y, Borisova M, Diken M, Strand S, Beli P, Tiwari VK., Free PMC Article | 10/6/2018 |
| Authors found that the FBXO32 and SMAD4 levels were higher in normal tissues than in CRC tissues. The expressions of FBXO32 and SMAD4 were related to clinicopathological parameters in CRC. | Preliminary Study of the Role F-Box Protein 32 (FBXO32) in Colorectal Neoplasms Through the Transforming Growth Factor beta (TGF-β)/Smad4 Signalling Pathway.
Yuan X, Zhang Z, Jiang K, Wang X, Li Y., Free PMC Article | 09/1/2018 |
| role of the muscle specific E3s MuRF-1 and MAFbx in skeletal muscle wasting during various pathologies, as well as their regulation by modifiable lifestyle factors, were explored (review) | The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass.
Rom O, Reznick AZ. | 12/23/2017 |
| FBXO32 activates NF-kappaB through IkappaBalpha degradation in inflammatory and genotoxic stress | FBXO32 activates NF-κB through IκBα degradation in inflammatory and genotoxic stress.
Meshram SN, Paul D, Manne R, Choppara S, Sankaran G, Agrawal Y, Santra MK. | 12/2/2017 |
| Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase FBXO32/atrogin-1 and its transcription factor FOXO3A. | Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.
Murdoch JD, Rostosky CM, Gowrisankaran S, Arora AS, Soukup SF, Vidal R, Capece V, Freytag S, Fischer A, Verstreken P, Bonn S, Raimundo N, Milosevic I., Free PMC Article | 11/25/2017 |
| Low FBXO32 expression is associated with breast cancer tumorigenesis. | FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation.
Zhou H, Liu Y, Zhu R, Ding F, Wan Y, Li Y, Liu Z., Free PMC Article | 10/14/2017 |
| the involvement of oxidative stress in the atrophy of COPD peripheral muscle cells in vitro, via the FoxO1/MuRF1/atrogin-1 signaling pathway of the ubiquitin/proteasome system | Involvement of the FoxO1/MuRF1/Atrogin-1 Signaling Pathway in the Oxidative Stress-Induced Atrophy of Cultured Chronic Obstructive Pulmonary Disease Myotubes.
Pomiès P, Blaquière M, Maury J, Mercier J, Gouzi F, Hayot M., Free PMC Article | 08/5/2017 |
| These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity. | Atrogin-1 Increases Smooth Muscle Contractility Through Myocardin Degradation.
Singh P, Li D, Gui Y, Zheng XL. | 05/13/2017 |
| Our results indicate that abnormal SCF activity with subsequent impairment of the autophagic flux due to a novel FBXO32 mutation is implicated in the pathogenesis of Dilated cardiomyopathy . | FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy.
Al-Yacoub N, Shaheen R, Awad SM, Kunhi M, Dzimiri N, Nguyen HC, Xiong Y, Al-Buraiki J, Al-Habeeb W, Alkuraya FS, Poizat C., Free PMC Article | 10/8/2016 |
| Our data suggest that FBXO32 is a candidate gene for recessive familial dilated cardiomyopathy. Acting as a cardiac ubiquitin ligase, mutated FBXO32 could perturb the degradation of target proteins in the ubiquitin proteasome system. | A substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathy.
Al-Hassnan ZN, Shinwari ZM, Wakil SM, Tulbah S, Mohammed S, Rahbeeni Z, Alghamdi M, Rababh M, Colak D, Kaya N, Al-Fayyadh M, Alburaiki J., Free PMC Article | 05/14/2016 |
| Vitamin D3 might have an inhibitory effect on the expression of MAFbx and MuRF1 in skeletal muscle. | 1α,25(OH)2D3 downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human myotubes.
Hayakawa N, Fukumura J, Yasuno H, Fujimoto-Ouchi K, Kitamura H. | 01/16/2016 |
| Atrogin-1 expression tended to be increased in the skeletal muscle of patients with malignant disease even before cancer related cachexia weight loss. | Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: an in vitro and in vivo study.
Yuan L, Han J, Meng Q, Xi Q, Zhuang Q, Jiang Y, Han Y, Zhang B, Fang J, Wu G. | 01/2/2016 |
| Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles | Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Bédard N, Jammoul S, Moore T, Wykes L, Hallauer PL, Hastings KE, Stretch C, Baracos V, Chevalier S, Plourde M, Coyne E, Wing SS. | 11/28/2015 |
| FBXO32 targets Lys-326 of c-Myc to form polyubiquitin chains, resulting in inhibition of cell proliferation. | FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity.
Mei Z, Zhang D, Hu B, Wang J, Shen X, Xiao W., Free PMC Article | 10/3/2015 |