| TIP39-PTH2R system appears to be a previously unrecognized mechanism for regulation of extracellular matrix formation and wound repair. | Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair.
Sato E, Zhang LJ, Dorschner RA, Adase CA, Choudhury BP, Gallo RL., Free PMC Article | 09/16/2017 |
| This study demonstrated that TIP39 signaling plays a role in fear incubation and suggest that may serve to ameliorate the long-term negative outcome of traumatic experience via PTH2R-expressing neurons in the Medial Nucleus of the Amygdala. | Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala.
Tsuda MC, Yeung HM, Kuo J, Usdin TB., Free PMC Article | 11/28/2015 |
| Data indicate that the nociceptive phenotype of TIP39-knockout {KO) mice was similar to the PTH2R-KO. | Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues.
Dimitrov EL, Kuo J, Kohno K, Usdin TB., Free PMC Article | 11/16/2013 |
| TIP39/PTH2R signaling inhibits proliferation and alters differentiation of chondrocytes by modulating SOX9 expression | TIP39/parathyroid hormone type 2 receptor signaling is a potent inhibitor of chondrocyte proliferation and differentiation.
Panda D, Goltzman D, Jüppner H, Karaplis AC., Free PMC Article | 03/17/2012 |
| Mice with PTH2R-null mutation lacking thermoregulation. | Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation.
Dimitrov EL, Kim YY, Usdin TB., Free PMC Article | 02/4/2012 |
| Involvement of the TIP39/PTH2-R system in the pathways involved in the successful development of the pups. | Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development.
Coutellier L, Logemann A, Rusnak M, Usdin TB., Free PMC Article | 11/12/2011 |
| This study demonistrated that suggested that TIP39 modulates long-term fear recall and that mice lacking TIP39 or its receptor are tools for investigating fear-related psychopathologies. | Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling.
Coutellier L, Usdin TB., Free PMC Article | 09/3/2011 |
| these results suggest that the TIP39/PTH2-R system modulates the effects of novelty exposure on memory performance, potentially by acting on noradrenergic signaling | TIP39 modulates effects of novelty-induced arousal on memory.
Coutellier L, Logemann A, Kuo J, Rusnak M, Usdin TB., Free PMC Article | 04/30/2011 |
| Data indicate that the TIP39 ligand/PTH2 receptor system provides facilitatory regulation of the hypothalamic-pituitary-adrenal axis via hypothalamic glutamatergic neurons and that it may regulate other neuroendocrine systems by a similar mechanism. | Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons.
Dimitrov E, Usdin TB., Free PMC Article | 01/15/2011 |
| TIP39 signaling modulates nociception, very likely by inhibiting endocannabinoid circuitry at a supraspinal level | Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception.
Dimitrov EL, Petrus E, Usdin TB., Free PMC Article | 10/30/2010 |
| Current data support the hypothesis that TIP39 modulates anxiety-related behaviors following environmental provocation. | Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues.
Fegley DB, Holmes A, Riordan T, Faber CA, Weiss JR, Ma S, Batkai S, Pacher P, Dobolyi A, Murphy A, Sleeman MW, Usdin TB., Free PMC Article | 01/21/2010 |
| TIP39 is essential for germ cell development and may act as an autocrine or paracrine agent within the gonads. | Tuberoinfundibular Peptide of 39 residues is required for germ cell development.
Usdin TB, Paciga M, Riordan T, Kuo J, Parmelee A, Petukova G, Camerini-Otero RD, Mezey E., Free PMC Article | 01/21/2010 |
| We propose that TIP39 is an endogenous ligand of the PTH2R and that they form a neuromodulator system, which is optimally positioned to regulate limbic, endocrine, and auditory brain functions. | Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain.
Faber CA, Dobolyi A, Sleeman M, Usdin TB., Free PMC Article | 01/21/2010 |
| PTH1 receptor antagonism | Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39).
Hoare SR, Usdin TB. | 01/21/2010 |