| Hypoxia-inducible factor-1alpha attenuates renal podocyte injury in male rats in a simulated high-altitude environment by upregulating Kruppel-like factor 4 expression. | Hypoxia-inducible factor-1α attenuates renal podocyte injury in male rats in a simulated high-altitude environment by upregulating Krüppel-like factor 4 expression.
Xiaoshan Z, Huan C, Zhilin G, Liwen M, Yan Z, Yue C., Free PMC Article | 07/11/2024 |
| N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells. | N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells.
Kang K, Sun C, Li H, Liu X, Deng J, Chen S, Zeng L, Chen J, Liu X, Kuang J, Xiang J, Cheng J, Liao X, Lin M, Zhang X, Zhan C, Liu S, Wang J, Niu Y, Liu C, Liang C, Zhu J, Liang S, Tang H, Gou D., Free PMC Article | 06/26/2024 |
| Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Kruppel-Like Factor 4. | Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel-Like Factor 4.
Du BB, Zhang JL, Kong LY, Shi HT, Zhang DH, Wang X, Yang CL, Li PC, Yao R, Liang C, Wu LM, Huang Z., Free PMC Article | 01/3/2024 |
| MicroRNA-29a-3p Accelerates Inflammatory Damage in Neonatal Pneumonia Via Targeting Kruppel-like Factor 4. | MicroRNA-29a-3p Accelerates Inflammatory Damage in Neonatal Pneumonia Via Targeting Krüppel-like Factor 4.
Xu XJ, Liu W, Liland S. | 12/20/2023 |
| Depletion of microRNA-92a Enhances the Role of Sevoflurane Treatment in Reducing Myocardial Ischemia-Reperfusion Injury by Upregulating KLF4. | Depletion of microRNA-92a Enhances the Role of Sevoflurane Treatment in Reducing Myocardial Ischemia-Reperfusion Injury by Upregulating KLF4.
Wu Q, Wang H, He F, Zheng J, Zhang H, Cheng C, Hu P, Lu R, Yan G. | 12/18/2023 |
| Protective effects of KLF4 on blood-brain barrier and oxidative stress after cerebral ischemia-reperfusion in rats through the Nrf2/Trx1 pathway. | Protective effects of KLF4 on blood-brain barrier and oxidative stress after cerebral ischemia-reperfusion in rats through the Nrf2/Trx1 pathway.
Huang T, Yin J, Ren S, Zhang X. | 08/11/2023 |
| Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension. | Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension.
Liu Y, Luo Y, Shi X, Lu Y, Li H, Fu G, Li X, Shan L. | 08/9/2023 |
| microRNA-130b May Induce Cerebral Vasospasm after Subarachnoid Hemorrhage via Modulating Kruppel-like Factor 4. | microRNA-130b May Induce Cerebral Vasospasm after Subarachnoid Hemorrhage via Modulating Kruppel-like Factor 4.
Huang Z, Hu J, Xu J, Wang H, Dai L., Free PMC Article | 07/20/2023 |
| Baihui (DU20)-penetrating-Qubin (GB7) acupuncture regulates microglia polarization through miR-34a-5p/Klf4 signaling in intracerebral hemorrhage rats. | Baihui (DU20)-penetrating-Qubin (GB7) acupuncture regulates microglia polarization through miR-34a-5p/Klf4 signaling in intracerebral hemorrhage rats.
Li D, Zhao Y, Bai P, Li Y, Wan S, Zhu X, Liu M., Free PMC Article | 11/27/2021 |
| Expressions and related mechanisms of miR-212 and KLF4 in rats with acute kidney injury. | Expressions and related mechanisms of miR-212 and KLF4 in rats with acute kidney injury.
Yang X, Li B, Guan Y, Jiang HM. | 07/17/2021 |
| Kruppel-like factor 4 upregulates matrix metalloproteinase 13 expression in chondrocytes via mRNA stabilization. | Kruppel-like factor 4 upregulates matrix metalloproteinase 13 expression in chondrocytes via mRNA stabilization.
Takeuchi Y, Tatsuta S, Kito A, Fujikawa J, Itoh S, Itoh Y, Akiyama S, Yamashiro T, Wakisaka S, Abe M. | 07/17/2021 |
| Downregulation of miR-34a ameliorates inflammatory response and apoptosis induced by renal ischemia-reperfusion by promoting Kruppel-like factor 4 expression. | Downregulation of miR-34a ameliorates inflammatory response and apoptosis induced by renal ischemia-reperfusion by promoting Kruppel-like factor 4 expression.
Shi YY, Ma YH, Zhang R, Li RS. | 07/3/2021 |
| MicroRNA29a promotes the neural differentiation of rat neural stem/progenitor cells by targeting KLF4. | MicroRNA‑29a promotes the neural differentiation of rat neural stem/progenitor cells by targeting KLF4.
Gao Y, Qiao H, Zhong T, Lu Z, Hou Y., Free PMC Article | 04/13/2021 |
| Leptin stimulates synaptogenesis in hippocampal neurons via KLF4 and SOCS3 inhibition of STAT3 signaling. | Leptin stimulates synaptogenesis in hippocampal neurons via KLF4 and SOCS3 inhibition of STAT3 signaling.
Sahin GS, Dhar M, Dillon C, Zhu M, Shiina H, Winters BD, Lambert TJ, Impey S, Appleyard SM, Wayman GA., Free PMC Article | 04/13/2021 |
| LH-induced Transcriptional Regulation of Klf4 Expression in Granulosa Cells Occurs via the cAMP/PKA Pathway and Requires a Putative Sp1 Binding Site. | LH-induced Transcriptional Regulation of Klf4 Expression in Granulosa Cells Occurs via the cAMP/PKA Pathway and Requires a Putative Sp1 Binding Site.
Choi H, Roh J., Free PMC Article | 03/6/2021 |
| Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B. | Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B.
Zhang X, Nham GTH, Ito K, Shinomura T. | 02/20/2021 |
| Apelin-13 promotes late endothelial progenitor cells differentiation by regulating Kruppel-like factor 4. | Apelin-13 promotes late endothelial progenitor cells differentiation by regulating Krüppel-like factor 4.
Yu M, Feng HJ, Abdalla AME, Teng YF, Li Q. | 12/12/2020 |
| Pioglitazone protects blood vessels through inhibition of the apelin signaling pathway by promoting KLF4 expression in rat models of T2DM. | Pioglitazone protects blood vessels through inhibition of the apelin signaling pathway by promoting KLF4 expression in rat models of T2DM.
Wang Y, Zhang R, Shen H, Kong J, Lv X., Free PMC Article | 10/24/2020 |
| KLF4 expression is regulated by p22phox in the vascular smooth muscle cells. | p22phox promotes Ang-II-induced vascular smooth muscle cell phenotypic switch by regulating KLF4 expression.
Tang Y, Huang Q, Liu C, Ou H, Huang D, Peng F, Liu C, Mo Z. | 07/25/2020 |
| Knockdown of AEG-1 suppresses autophagy in DCM by downregulating the expression of KLF4. This study provide first-notion evidence for the potential value of AEG-1 as a therapeutic target for the treatment of the patients with DCM. | Astrocyte elevated gene-1 induces autophagy in diabetic cardiomyopathy through upregulation of KLF4.
Zhao L, Zhang Q, Liang J, Li J, Tan X, Tang N. | 07/18/2020 |
| Klf4 suppressed endogenous Cyp19A1 transcript and protein production, and this resulted from direct binding of Klf4 to the SF1 recognition motif in the Cyp19A1 promoter. These findings suggest that Klf4 is a physiologic regulator of Cyp19A1 expression in response to the LH surge in preovulatory GCs and that it has an essential role in the luteal transition in steroidogenesis. | Krüppel-like factor 4 plays a role in the luteal transition in steroidogenesis by downregulating Cyp19A1 expression.
Choi H, Ryu KY, Roh J. | 01/4/2020 |
| Physiological stress could increase heme uptake via heme carrier protein 1 (HCP1) in brains through a transcription factor, Kruppel-like factor 4 (KLF4). | Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons.
Li H, Zhang C, Shen H, Shen Z, Wu L, Mo F, Li M., Free PMC Article | 02/23/2019 |
| data suggested that SNHG5 promotes spinal cord injury via increasing the viability of astrocytes and microglia. The mechanism by which SNHG5 works is its directive interaction to KLF4 and contribution to eNOS upregulation. | LncRNA SNHG5 enhances astrocytes and microglia viability via upregulating KLF4 in spinal cord injury.
Jiang ZS, Zhang JR. | 01/5/2019 |
| IRF4 protects arteries against neointima formation by promoting the expression of KLF4 by directly binding to its promoter. | Interferon Regulatory Factor 4 Inhibits Neointima Formation by Engaging Krüppel-Like Factor 4 Signaling.
Cheng WL, She ZG, Qin JJ, Guo JH, Gong FH, Zhang P, Fang C, Tian S, Zhu XY, Gong J, Wang ZH, Huang Z, Li H. | 10/21/2017 |
| the results provide critical insights into the newly discovered role of Shh in phenotypic modulation of vascular smooth muscle cells which depends on KLF4. | Shh mediates PDGF-induced contractile-to-synthetic phenotypic modulation in vascular smooth muscle cells through regulation of KLF4.
Zeng Q, Wei B, Zhao Y, Wang X, Fu Q, Liu H, Li F. | 05/20/2017 |