| ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease. | ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease.
Jiménez-Moreno N, Lane JD., Free PMC Article | 05/1/2024 |
| An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins. | An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins.
Brennan A, Layfield R, Long J, Williams HEL, Oldham NJ, Scott D, Searle MS., Free PMC Article | 05/21/2022 |
| The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment. | The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment.
Timimi L, Figueras-Novoa C, Marcassa E, Florey O, Baillie JK, Beale R, Ulferts R., Free PMC Article | 05/7/2022 |
| Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity. | Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity.
Wirth M, Mouilleron S, Zhang W, Sjøttem E, Princely Abudu Y, Jain A, Lauritz Olsvik H, Bruun JA, Razi M, Jefferies HBJ, Lee R, Joshi D, O'Reilly N, Johansen T, Tooze SA., Free PMC Article | 08/28/2021 |
| Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine. | Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
Durgan J, Lystad AH, Sloan K, Carlsson SR, Wilson MI, Marcassa E, Ulferts R, Webster J, Lopez-Clavijo AF, Wakelam MJ, Beale R, Simonsen A, Oxley D, Florey O., Free PMC Article | 06/19/2021 |
| Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2. | Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2.
Lu G, Rao D, Zhou M, Liangpu Xu, Zhang L, Zhang S, Wang Y., Free PMC Article | 04/17/2021 |
| A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy. | A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.
Fracchiolla D, Chang C, Hurley JH, Martens S., Free PMC Article | 03/20/2021 |
| Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition. | Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition.
Sanwald JL, Dobner J, Simons IM, Poschmann G, Stühler K, Üffing A, Hoffmann S, Willbold D., Free PMC Article | 03/13/2021 |
| Curvature-sensitive trans-assembly of human Atg8-family proteins in autophagy-related membrane tethering. | Curvature-sensitive trans-assembly of human Atg8-family proteins in autophagy-related membrane tethering.
Taniguchi S, Toyoshima M, Takamatsu T, Mima J., Free PMC Article | 02/27/2021 |
| An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5. | An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.
Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV., Free PMC Article | 11/28/2020 |
| GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon. | GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon.
Zhang Z, Gu H, Li Q, Zheng J, Cao S, Weng C, Jia H., Free PMC Article | 10/24/2020 |
| TEX264, an endoplasmic reticulum (ER)resident protein, remodels subdomainsof the ER into ring-like structures inassociation with ATG8 proteins uponnutrient stress, which then fuse withlysosomes for ER turnover. | TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.
An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW., Free PMC Article | 10/26/2019 |
| Trim5alpha binds all mammalian ATG8s and that, unlike the typical LC3-interacting region (LIR) that binds to mammalian ATG8s through a beta-strand motif comprising approximately six residues, LC3B binds to Trim5alpha via the alpha-helical coiled-coil region. | A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins.
Keown JR, Black MM, Ferron A, Yap M, Barnett MJ, Pearce FG, Stoye JP, Goldstone DC., Free PMC Article | 06/29/2019 |
| Ribophagic flux was not induced upon inhibition of translational elongation or nascent chain uncoupling, but was induced in a comparatively selective manner under proteotoxic stress induced by arsenite (10) or chromosome mis-segregation (11) , dependent upon VPS34 and ATG8 conjugation | Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy.
An H, Harper JW., Free PMC Article | 04/13/2019 |
| This work defines unique roles for GABARAP and LC3 subfamilies in macroautophagy and selective autophagy and demonstrates how analysis of autophagic machinery in the absence of flux can identify new regulatory circuits. | Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux.
Vaites LP, Paulo JA, Huttlin EL, Harper JW., Free PMC Article | 04/6/2019 |
| Study supports the idea that protein levels of parkin associated endothelin like receptor are likely regulated by a multitude of proteins including parkin, protein kinase C interacting protein and gamma-aminobutyrate type A receptor associated protein like 2 via mechanisms that include ubiquitination, proteasomal degradagtion and autophagy. | A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.
Dutta P, Dargahi L, O'Connell KE, Bolia A, Ozkan B, Sailer AW, Dev KK. | 03/16/2019 |
| Stx17 directly interacts with IRGM, and efficient Stx17 recruitment to autophagosomes requires IRGM. Both IRGM and Stx17 directly interact with mammalian Atg8 proteins, thus being guided to autophagosomes. | Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.
Kumar S, Jain A, Farzam F, Jia J, Gu Y, Choi SW, Mudd MH, Claude-Taupin A, Wester MJ, Lidke KA, Rusten TE, Deretic V., Free PMC Article | 02/23/2019 |
| GABARAPs are identified as the first known direct interaction partners of Nef that are essential for its plasma membrane localization. | Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization.
Boeske A, Schwarten M, Ma P, Tusche M, Mötter J, Möller C, Neudecker P, Hoffmann S, Willbold D., Free PMC Article | 02/9/2019 |
| GATE-16 regulates TWEAK signaling by Fn14 and thereby NF-kappaB activity. Fn14 accumulates in the ERGIC in absence of GABARAP but within endosomes in the vicinity of autophagic membranes in absence of GATE-16. | Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins.
Winer H, Fraiberg M, Abada A, Dadosh T, Tamim-Yecheskel BC, Elazar Z., Free PMC Article | 01/19/2019 |
| This study reveals the important role of SERP1/Ysy6 and Atg8 in endoplasmic reticulum stress response and virulence in Candida albicans. | Stress-associated endoplasmic reticulum protein 1 (SERP1) and Atg8 synergistically regulate unfolded protein response (UPR) that is independent on autophagy in Candida albicans.
Li J, Yu Q, Zhang B, Xiao C, Ma T, Yi X, Liang C, Li M. | 11/24/2018 |
| Mechanism of cargo-directed Atg8 conjugation during selective autophagy has been described. | Mechanism of cargo-directed Atg8 conjugation during selective autophagy.
Fracchiolla D, Sawa-Makarska J, Zens B, Ruiter A, Zaffagnini G, Brezovich A, Romanov J, Runggatscher K, Kraft C, Zagrovic B, Martens S., Free PMC Article | 11/25/2017 |
| Cardiolipin interaction with various Atg8 human orthologs, namely LC3B, GABARAPL2 and GABARAP, was investigated. | Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP.
Antón Z, Landajuela A, Hervás JH, Montes LR, Hernández-Tiedra S, Velasco G, Goñi FM, Alonso A., Free PMC Article | 11/18/2017 |
| rs12599322 in ATG8 was significantly associated with higher DNA damage levels in Chinese population. | Genetic variants in autophagy associated genes are associated with DNA damage levels in Chinese population.
Li Z, Xin J, Chen W, Liu J, Zhu M, Zhao C, Yuan J, Jin G, Ma H, Du J, Hu Z, Wu T, Shen H, Dai J, Yu H. | 08/5/2017 |
| describe a protocol for the reconstituted conjugation systems for mammalian Atg8 homologs in vitro using purified recombinant Atg proteins and liposomes. | In vitro assays of lipidation of Mammalian Atg8 homologs.
Tanida I, Ueno T, Kominami E. | 07/2/2016 |
| Using X-ray crystallography and NMR spectroscopy, the structural transition centered on the C-terminus of GATE-16 protein was identified. | Conformational Polymorphism in Autophagy-Related Protein GATE-16.
Ma P, Schillinger O, Schwarten M, Lecher J, Hartmann R, Stoldt M, Mohrlüder J, Olubiyi O, Strodel B, Willbold D, Weiergräber OH. | 11/28/2015 |