| Inhibition of MAGL attenuates Intervertebral Disc Degeneration by Delaying nucleus pulposus senescence through STING. | Inhibition of MAGL attenuates Intervertebral Disc Degeneration by Delaying nucleus pulposus senescence through STING.
Fan C, Du J, Yu Z, Wang J, Yao L, Ji Z, He W, Deng Y, Geng D, Wu X, Mao H. | 04/22/2024 |
| MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity. | MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity.
Zhou S, Ling X, Zhu J, Liang Y, Feng Q, Xie C, Li J, Chen Q, Chen S, Miao J, Zhang M, Li Z, Shen W, Li X, Wu Q, Wang X, Liu R, Wang C, Hou FF, Kong Y, Liu Y, Zhou L., Free PMC Article | 02/28/2024 |
| IL-8-induced CXCR2 down-regulation in circulating monocytes in hepatocellular carcinoma is partially dependent on MAGL. | IL-8-induced CXCR2 down-regulation in circulating monocytes in hepatocellular carcinoma is partially dependent on MAGL.
Liu CZ, Liu XB, Sun J, Yu CQ, Yao JC, Liu Z, Hao JC., Free PMC Article | 07/7/2023 |
| Decreased serum levels of glycerol-3- phosphate dehydrogenase 1 and monoacylglycerol lipase act as diagnostic biomarkers for breast cancer. | Decreased serum levels of glycerol-3- phosphate dehydrogenase 1 and monoacylglycerol lipase act as diagnostic biomarkers for breast cancer.
Karaosmanoglu Yoneten K, Kasap M, Arga KY, Akpinar G, Utkan NZ. | 05/14/2022 |
| Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis. | Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis.
Zhang J, Song Y, Shi Q, Fu L. | 11/27/2021 |
| Brain structural changes in cannabis dependence: association with MAGL. | Brain structural changes in cannabis dependence: association with MAGL.
Manza P, Yuan K, Shokri-Kojori E, Tomasi D, Volkow ND., Free PMC Article | 06/19/2021 |
| Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease. | Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease.
Syal C, Kosaraju J, Hamilton L, Aumont A, Chu A, Sarma SN, Thomas J, Seegobin M, Dilworth FJ, He L, Wondisford FE, Zimmermann R, Parent M, Fernandes K, Wang J., Free PMC Article | 05/22/2021 |
| Conformational gating, dynamics and allostery in human monoacylglycerol lipase. | Conformational gating, dynamics and allostery in human monoacylglycerol lipase.
Tyukhtenko S, Ma X, Rajarshi G, Karageorgos I, Anderson KW, Hudgens JW, Guo JJ, Nasr ML, Zvonok N, Vemuri K, Wagner G, Makriyannis A., Free PMC Article | 01/16/2021 |
| ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages. | ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages.
Yin J, Kim SS, Choi E, Oh YT, Lin W, Kim TH, Sa JK, Hong JH, Park SH, Kwon HJ, Jin X, You Y, Kim JH, Kim H, Son J, Lee J, Nam DH, Choi KS, Shi B, Gwak HS, Yoo H, Iavarone A, Kim JH, Park JB., Free PMC Article | 08/29/2020 |
| Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells | Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells.
Szeremeta J, Karlsson J, Alhouayek M, Fowler CJ. | 02/1/2020 |
| The expression level of MAGL has positive correlation with the malignant degree in hepatocellular carcinoma patients, and negative correlation with prognosis | [Monoacylglycerol lipase high expression as an independent indicator of survival for patients with hepatocellular carcinoma].
Liu Y, Yang XL, Gong JP, Zhang JY. | 11/23/2019 |
| overexpression of MAGL inhibits the proliferation of MHCC97H hepatocellular carcinoma cells in vivo, and its mechanism may be associated to the release of inflammatory factors from tumor-associated macrophages | [Effect of monoacylglycerol lipase with proliferation of MHCC97H human liver cancer cells in vivo].
Zhu WP, He XG, Zhao YM, Pan Q, Zhang N, Zhou JM, Wang LR, Wang M, Liu ZY, Zhu HX, Wang L. | 10/12/2019 |
| Study utilizing colorectal cancer patients tissue samples, mouse tumor cell lines and xenograft models identify MGLL as a switch for CB2/TLR4-dependent macrophage activation and provide potential targets for cancer therapy. | Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression.
Xiang W, Shi R, Kang X, Zhang X, Chen P, Zhang L, Hou A, Wang R, Zhao Y, Zhao K, Liu Y, Ma Y, Luo H, Shang S, Zhang J, He F, Yu S, Gan L, Shi C, Li Y, Yang W, Liang H, Miao H., Free PMC Article | 01/19/2019 |
| Using a multimethod approach, the authors show that the dynamically relevant Trp-289 and Leu-232 residues serve as communication hubs within an allosteric protein network that controls signal propagation to the active site, and thus, regulates active-inactive interconversion of human MGL. | Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase.
Tyukhtenko S, Rajarshi G, Karageorgos I, Zvonok N, Gallagher ES, Huang H, Vemuri K, Hudgens JW, Ma X, Nasr ML, Pavlopoulos S, Makriyannis A., Free PMC Article | 12/22/2018 |
| RNA interference, specific pharmacological inhibitor JZL-184 and gene knock-in of MAGL were utilized to investigate the effects of MAGL on hepatocellular carcinoma (HCC) cell proliferation, apoptosis, and invasion. MAGL played important roles in both proliferation and invasion of HCC cells. | Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma.
Zhang J, Liu Z, Lian Z, Liao R, Chen Y, Qin Y, Wang J, Jiang Q, Wang X, Gong J., Free PMC Article | 04/28/2018 |
| This review summarizes the basics of monoglyceride metabolism and provides an overview on the therapeutic potential of MGL. [Review] | Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling.
Grabner GF, Zimmermann R, Schicho R, Taschler U., Free PMC Article | 03/24/2018 |
| MGLL may have a role in progression of gastrointestinal stromal tumors | Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors.
Li CF, Chuang IC, Liu TT, Chen KC, Chen YY, Fang FM, Li SH, Chen TJ, Yu SC, Lan J, Huang HY., Free PMC Article | 02/24/2018 |
| the upregulation of MAGL in hepatocellular carcinoma cells promoted cell growth and invasiveness abilities, and mediated epithelial-mesenchymal transition | Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition.
Zhu W, Zhao Y, Zhou J, Wang X, Pan Q, Zhang N, Wang L, Wang M, Zhan D, Liu Z, He X, Ma D, Liu S, Wang L., Free PMC Article | 11/25/2017 |
| we clarify the key role of Phe159 and Ile179, two conserved residues within the lid domain, in regulating substrate specificity in MAGL. We conclude by proposing that other structurally related lipases may share this lid-domain-mediated mechanism for substrate specificity. | Lid domain plasticity and lipid flexibility modulate enzyme specificity in human monoacylglycerol lipase.
Riccardi L, Arencibia JM, Bono L, Armirotti A, Girotto S, De Vivo M. | 07/15/2017 |
| the presence and differential distribution of fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGLL) in relation to CB1 during the maturation of human oocytes, was investigated. | Dynamic of expression and localization of cannabinoid-degrading enzymes FAAH and MGLL in relation to CB1 during meiotic maturation of human oocytes.
Agirregoitia E, Totorikaguena L, Expósito A, Mendoza R, Matorras R, Agirregoitia N. | 05/20/2017 |
| there was evidence that MGLL rs604300 genotype interacts with early life adversity to predict threat-related basolateral amygdala habituation, a neural phenotype linked to the endocannabinoid system and addiction | Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.
Carey CE, Agrawal A, Zhang B, Conley ED, Degenhardt L, Heath AC, Li D, Lynskey MT, Martin NG, Montgomery GW, Wang T, Bierut LJ, Hariri AR, Nelson EC, Bogdan R., Free PMC Article | 12/17/2016 |
| This study unravels a novel mechanism of SND1 function and identifies MGLL as a unique tumor suppressor for HCC. MGLL might function as a homeostatic regulator of Akt restraining its activation. | Staphylococcal Nuclease and Tudor Domain Containing 1 (SND1 Protein) Promotes Hepatocarcinogenesis by Inhibiting Monoglyceride Lipase (MGLL).
Rajasekaran D, Jariwala N, Mendoza RG, Robertson CL, Akiel MA, Dozmorov M, Fisher PB, Sarkar D., Free PMC Article | 11/12/2016 |
| The data highlight specific inter-residue interactions within hMGL | Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency: A ROLE FOR GLOBAL CONFORMATIONAL CHANGES.
Tyukhtenko S, Karageorgos I, Rajarshi G, Zvonok N, Pavlopoulos S, Janero DR, Makriyannis A., Free PMC Article | 07/2/2016 |
| Monoacylglycerol lipase sulfenylation might act as an intrinsic neuroprotective mechanism by potentiating 2-AG signaling at CB1 receptors. | Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons.
Dotsey EY, Jung KM, Basit A, Wei D, Daglian J, Vacondio F, Armirotti A, Mor M, Piomelli D., Free PMC Article | 02/20/2016 |
| The study identified monoacylglycerol lipase as a YAP transcriptional target and an inhibitor of anchorage-dependent cell growth. | YAP-mediated induction of monoacylglycerol lipase restrains oncogenic transformation.
Tang ED, Wang CY., Free PMC Article | 12/26/2015 |