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    CBX3 chromobox 3 [ Homo sapiens (human) ]

    Gene ID: 11335, updated on 6-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.

    CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.
    Chen J, Lin Y, Zheng S, Chen Q, Tang S, Zhong X., Free PMC Article

    09/8/2023
    PSMC4 promotes prostate carcinoma progression by regulating the CBX3-EGFR-PI3K-AKT-mTOR pathway.

    PSMC4 promotes prostate carcinoma progression by regulating the CBX3-EGFR-PI3K-AKT-mTOR pathway.
    Liu K, Zhang S, Gong Y, Zhu P, Shen W, Zhang Q., Free PMC Article

    08/19/2023
    CBX3 promotes breast cancer progression and high level of CBX3 predicts poor prognosis in patients.

    CBX3 promotes breast cancer progression and high level of CBX3 predicts poor prognosis in patients.
    Yang K, Wang YL, Zhu Z, Cao XH, Liang MX, Xu D, Fei YJ, Yang SY, Zhou HL, Tang JH.

    03/17/2023
    The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis.

    The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis.
    Mata-Garrido J, Xiang Y, Chang-Marchand Y, Reisacher C, Ageron E, Guerrera IC, Casafont I, Bruneau A, Cherbuy C, Treton X, Dumay A, Ogier-Denis E, Batsché E, Costallat M, Revêchon G, Eriksson M, Muchardt C, Arbibe L., Free PMC Article

    12/3/2022
    CBX3 regulated by miR-139 promotes the development of HCC by regulating cell cycle progression.

    CBX3 regulated by miR-139 promotes the development of HCC by regulating cell cycle progression.
    Zhang P, Yang X, Zha Z, Zhu Y, Zhang G, Li G., Free PMC Article

    07/30/2022
    CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression.

    CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression.
    Zhang H, Yu H, Ren D, Sun Y, Guo F, Cai H, Zhou C, Zhou Y, Jin X, Wu H., Free PMC Article

    06/11/2022
    CBX3 accelerates the malignant progression of glioblastoma multiforme by stabilizing EGFR expression.

    CBX3 accelerates the malignant progression of glioblastoma multiforme by stabilizing EGFR expression.
    Peng W, Shi S, Zhong J, Liang H, Hou J, Hu X, Wang F, Zhang J, Geng S, Sun X, Zhong D, Cui H.

    06/11/2022
    Comprehensive pan-cancer analysis on CBX3 as a prognostic and immunological biomarker.

    Comprehensive pan-cancer analysis on CBX3 as a prognostic and immunological biomarker.
    Niu H, Chen P, Fan L, Sun B., Free PMC Article

    04/16/2022
    Clinicopathological significance of CBX3 in colorectal cancer: An intensive expression study based on formalin-fixed and paraffin-embedded tissues.

    Clinicopathological significance of CBX3 in colorectal cancer: An intensive expression study based on formalin-fixed and paraffin-embedded tissues.
    Wang H, Zhao W, Wang J, Zhang Z.

    03/19/2022
    HP1 proteins compact DNA into mechanically and positionally stable phase separated domains.

    HP1 proteins compact DNA into mechanically and positionally stable phase separated domains.
    Keenen MM, Brown D, Brennan LD, Renger R, Khoo H, Carlson CR, Huang B, Grill SW, Narlikar GJ, Redding S., Free PMC Article

    01/29/2022
    Diverse CBX family members as potential prognostic biomarkers in non-small-cell lung cancer.

    Diverse CBX family members as potential prognostic biomarkers in non-small-cell lung cancer.
    Xie X, Ning Y, Long J, Wang H, Chen X., Free PMC Article

    11/27/2021
    Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy.

    Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy.
    Suetake I, Nakazawa S, Sato K, Mutoh R, Mishima Y, Kawakami T, Takei T, Watanabe M, Sakai N, Fujiwara T, Takui T, Miyata M, Shinohara A, Hojo H, Arata T.

    11/22/2021
    LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma.

    LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma.
    Huang Y, Lin Y, Song X, Wu D.

    10/2/2021
    HPV-mediated nuclear export of HP1gamma drives cervical tumorigenesis by downregulation of p53.

    HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53.
    Yi SA, Lee DH, Kim GW, Ryu HW, Park JW, Lee J, Han J, Park JH, Oh H, Lee J, Choi J, Kim HS, Kang HG, Kim DH, Chun KH, You JS, Han JW, Kwon SH., Free PMC Article

    09/25/2021
    microRNA-377 acts as a suppressor in esophageal squamous cell carcinoma through CBX3-dependent P53/P21 pathway.

    microRNA-377 acts as a suppressor in esophageal squamous cell carcinoma through CBX3-dependent P53/P21 pathway.
    He Z, Chen J, Chen X, Wang H, Tang L, Han C.

    09/4/2021
    Clinicopathological and Prognostic Significance of CBX3 Expression in Human Cancer: a Systematic Review and Meta-analysis.

    Clinicopathological and Prognostic Significance of CBX3 Expression in Human Cancer: a Systematic Review and Meta-analysis.
    Lin H, Zhao X, Xia L, Lian J, You J., Free PMC Article

    08/28/2021
    LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis.

    LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis.
    Cai H, Yu Y, Ni X, Li C, Hu Y, Wang J, Chen F, Xi S, Chen Z., Free PMC Article

    04/13/2021
    HP1gamma Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3.

    HP1γ Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3.
    Yi SA, Kim GW, Yoo J, Han JW, Kwon SH., Free PMC Article

    02/20/2021
    Residues flanking the ARK(me3)T/S motif allow binding of diverse targets to the HP1 chromodomain: Insights from molecular dynamics simulations.

    Residues flanking the ARK(me3)T/S motif allow binding of diverse targets to the HP1 chromodomain: Insights from molecular dynamics simulations.
    Pokorná P, Krepl M, Šponer J.

    01/16/2021
    CBX3/HP1gamma promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma.

    CBX3/HP1γ promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma.
    Zhong X, Kan A, Zhang W, Zhou J, Zhang H, Chen J, Tang S., Free PMC Article

    08/22/2020
    High CBX3 expression is associated with glioma.

    CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis.
    Zhao SP, Wang F, Yang M, Wang XY, Jin CL, Ji QK, Li S, Zhao XL.

    02/15/2020
    The oncogenic function of circ-EZH2 was partly dependent on its modulation of DDAH1 and CBX3.

    Circ-EZH2 knockdown reverses DDAH1 and CBX3-mediated cell growth and invasion in glioma through miR-1265 sponge activity.
    Gao F, Du Y, Zhang Y, Ren D, Xu J, Chen D.

    01/11/2020
    Direct epigenetic repression of the transcription-repressive regulators NCOR2 and ZBTB7A by the histone reader protein HP1gamma leads to activation of protumorigenic genes in lung adenocarcinoma.

    HP1γ Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A.
    Alam H, Li N, Dhar SS, Wu SJ, Lv J, Chen K, Flores ER, Baseler L, Lee MG., Free PMC Article

    08/31/2019
    CBX3 is of great significance in the prognosis and progression of human osteosarcoma. CBX3 is highly expressed in human osteosarcoma tissues. The dismal prognosis of patients suffering from osteosarcoma can be predicted by high CBX3 expression.

    CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma.
    Ma C, Nie XG, Wang YL, Liu XH, Liang X, Zhou QL, Wu DP., Free PMC Article

    08/3/2019
    We report a significant upregulation of CBX3/HP1-gamma in non-small cell lung cancer patients

    CBX3/heterochromatin protein 1 gamma is significantly upregulated in patients with non-small cell lung cancer.
    Chang SC, Lai YC, Chen YC, Wang NK, Wang WS, Lai JI.

    05/18/2019
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