| CD300a and CD300f molecules regulate the function of leukocytes. | CD300a and CD300f molecules regulate the function of leukocytes.
Cao Y, Ao T, Wang X, Wei W, Fan J, Tian X. | 06/5/2021 |
| CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells [Review]. | CD300 receptor family in viral infections.
Vitallé J, Terrén I, Orrantia A, Zenarruzabeitia O, Borrego F. | 05/30/2020 |
| Results provide an insight into the novel set of paired receptors CD300a and CD300c that are distinctively expressed on CD56(bright) natural killers (NK) cells with varied effector functions and show there differential binding to their ligands phosphatidylethanolamine and phosphatidylserine (PS) resulting in their differential ability to affect CD56(bright) NK cell functions. | CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.
Dimitrova M, Zenarruzabeitia O, Borrego F, Simhadri VR., Free PMC Article | 03/11/2017 |
| High CD300A expression is associated with diffuse large B-cell lymphoma. | Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma.
Jiang L, Xu Y, Zeng X, Fang J, Morse HC 3rd, Zhou JX., Free PMC Article | 08/27/2016 |
| US3 protein kinase of pseudorabies virus triggers the binding of the inhibitory natural killer cell receptor CD300a to the surface of the infected cell, and protects of virus infected cells against natural killer cell-mediated lysis. | Pseudorabies Virus US3 Protein Kinase Protects Infected Cells from NK Cell-Mediated Lysis via Increased Binding of the Inhibitory NK Cell Receptor CD300a.
Grauwet K, Vitale M, De Pelsmaeker S, Jacob T, Laval K, Moretta L, Parodi M, Parolini S, Cantoni C, Favoreel HW., Free PMC Article | 05/28/2016 |
| Overall, these data indicate that CD300a is a novel Dengue virus binding receptor that recognizes phosphatidylethanolamine and phosphatidylserine present on virions and enhance infection. | The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection.
Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Hafirassou ML, Kitaura J, Ramdasi R, Schwartz O, Amara A., Free PMC Article | 04/30/2016 |
| Data show that peroxisome proliferator activator receptor delta (PPARdelta/beta) directly regulates CD300a protein in macrophages. | PPARβ/δ activation of CD300a controls intestinal immunity.
Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J., Free PMC Article | 10/31/2015 |
| CD300a induction by the hypoxic environment represents a mechanism of regulation of monocyte/macrophage pro-inflammatory responses at pathologic sites | Identification of CD300a as a new hypoxia-inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages.
Raggi F, Blengio F, Eva A, Pende D, Varesio L, Bosco MC. | 05/23/2015 |
| interaction with phosphatidylserines inhibits IgE/FcepsilonRI-dependent anaphylactic basophil degranulation | Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a.
Sabato V, Boita M, Shubber S, Bridts CH, Shibuya A, De Clerck LS, Falcone FH, Ebo DG. | 04/18/2015 |
| The inhibitory receptor CD300a is regulator of monocytes transendothelial migration. | Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration.
Ghavampour S, Lange C, Bottino C, Gerke V., Free PMC Article | 06/7/2014 |
| SHP-1, but not SHP-2 or the src homology 2 domain containing inositol 5' phosphatase SHIP, was utilized by CD300a for its inhibitory activity. These studies provide new insights into the function of CD300a in tuning T and B cell responses. | Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a.
DeBell KE, Simhadri VR, Mariano JL, Borrego F., Free PMC Article | 11/24/2012 |
| CD300a is expressed on human peripheral blood basophils and rapidly up-regulated upon cross-linking of IgE/Fc-epsilon-RI and suppresses anaphylactic degranulation. | CD300a is expressed on human basophils and seems to inhibit IgE/FcεRI-dependent anaphylactic degranulation.
Sabato V, Verweij MM, Bridts CH, Levi-Schaffer F, Gibbs BF, De Clerck LS, Schiavino D, Ebo DG. | 09/1/2012 |
| our results indicate that phosphatidylethanolamine and phosphatidylserine are ligands for CD300a, and that this interaction plays an important role in regulating the removal of dead cells. | Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells.
Simhadri VR, Andersen JF, Calvo E, Choi SC, Coligan JE, Borrego F., Free PMC Article | 05/12/2012 |
| These results indicated that CD300a is a new phosphatidylserine receptor. | Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor.
Nakahashi-Oda C, Tahara-Hanaoka S, Honda S, Shibuya K, Shibuya A. | 03/24/2012 |
| CD300a blocked TLR4-mediated and TLR9-mediated expression of pro-inflammatory mediators without affecting TLR3-mediated events. | CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines.
Kim EJ, Lee SM, Suk K, Lee WH., Free PMC Article | 03/17/2012 |
| differential expression on human TH1 and TH17 cell memory subsets | Differential expression of CD300a/c on human TH1 and TH17 cells.
Simhadri VR, Mariano JL, Zhou Q, DeBell KE, Borrego F., Free PMC Article | 01/28/2012 |
| Down-regulation of CD300a is associated with HIV infection. | CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection.
Silva R, Moir S, Kardava L, Debell K, Simhadri VR, Ferrando-Martínez S, Leal M, Peña J, Coligan JE, Borrego F., Free PMC Article | 09/10/2011 |
| CD300a is an inhibitory receptor expressed by human natural killer (NK) cells, but surprisingly, not all NK clones are inhibited in a CD300a-dependent manner. | Expression and function of CD300 in NK cells.
Lankry D, Simic H, Klieger Y, Levi-Schaffer F, Jonjic S, Mandelboim O. | 10/30/2010 |
| CD300a(+) human Th1 cells tend to be polyfunctional and after stimulation up-regulate Eomes. | Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin.
Narayanan S, Silva R, Peruzzi G, Alvarez Y, Simhadri VR, Debell K, Coligan JE, Borrego F., Free PMC Article | 09/13/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs; CD300a/c RNA and surface expression were downregulated after stimulation of pDCs with TLR7 and TLR9 ligands | CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands.
Ju X, Zenke M, Hart DN, Clark GJ. | 01/21/2010 |
| CD300a as a novel regulator of Kit in human MC and suggest roles for this receptor as a suppressor of Kit signaling in MC-related disorders. | Suppression of normal and malignant kit signaling by a bispecific antibody linking kit with CD300a.
Bachelet I, Munitz A, Berent-Maoz B, Mankuta D, Levi-Schaffer F. | 01/21/2010 |
| Human neutrophils from peripheral blood express the ITIM containing CD300a (also known as IRp60 and CMRF-35H) receptor. Co-ligation of CD300a with (FcgammaRIIa) activation receptor inhibited CD32a mediated signalling. | The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling.
Alvarez Y, Tang X, Coligan JE, Borrego F., Free PMC Article | 01/21/2010 |
| CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35H is an inhibitory molecule [review] | CMRF-35A, CMRF-35H: potential new CD.
Clark GJ, Fitzpatrick S, Kuo B, Modra C, Jamriska L, Hart DN. | 01/21/2010 |
| IRp60 is constitutively expressed on mast cells but is down-regulated by eosinophil major basic protein and eosinophil-derived neurotoxin. Cross-linking of IRp60 led to inhibition of IgE-induced degranulation and stem cell factor-mediated survival | The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells.
Bachelet I, Munitz A, Moretta A, Moretta L, Levi-Schaffer F. | 01/21/2010 |