| Prenatal phthalate exposure and cord blood DNA methylation. | Prenatal phthalate exposure and cord blood DNA methylation.
Lee J, Kim J, Zinia SS, Park J, Won S, Kim WJ., Free PMC Article | 05/15/2023 |
| Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging. | Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging.
Zhang Y, Shen WJ, Qiu S, Yang P, Dempsey G, Zhao L, Zhou Q, Hao X, Dong D, Stahl A, Kraemer FB, Leung LL, Morser J., Free PMC Article | 07/24/2021 |
| The findings indicate that differential methylation at CpG sites upstream of the CHN2 and JAK2 TSS regions are possible peripheral predictors of antidepressant treatment response. | Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants.
Ju C, Fiori LM, Belzeaux R, Theroux JF, Chen GG, Aouabed Z, Blier P, Farzan F, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Milev R, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Uher R, Li Q, Foster JA, Kennedy SH, Turecki G., Free PMC Article | 07/18/2020 |
| our data redefine the role of beta2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression. | A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.
Casado-Medrano V, Barrio-Real L, García-Rostán G, Baumann M, Rocks O, Caloca MJ., Free PMC Article | 12/16/2017 |
| this study shows that serum chemerin is an independent risk factor of prognosis of non-small cell lung cancer patients | Prognostic significance of serum chemerin levels in patients with non-small cell lung cancer.
Xu CH, Yang Y, Wang YC, Yan J, Qian LH., Free PMC Article | 09/16/2017 |
| CHN2 is consistently hypermethylated and downregulated in small bowel adenocarcinoma with diagnostic potential | Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility.
Alvi MA, McArt DG, Kelly P, Fuchs MA, Alderdice M, McCabe CM, Bingham V, McGready C, Tripathi S, Emmert-Streib F, Loughrey MB, McQuaid S, Maxwell P, Hamilton PW, Turkington R, James JA, Wilson RH, Salto-Tellez M., Free PMC Article | 04/29/2016 |
| CHN2, ABCB1 and PPP1R9A expression on chromosome 7 is implicated in the pathogenesis of hepatosplenic T-cell lymphoma distinguishing it from other malignancies. | Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma.
Finalet Ferreiro J, Rouhigharabaei L, Urbankova H, van der Krogt JA, Michaux L, Shetty S, Krenacs L, Tousseyn T, De Paepe P, Uyttebroeck A, Verhoef G, Taghon T, Vandenberghe P, Cools J, Wlodarska I., Free PMC Article | 04/25/2015 |
| genetic association studies in a population in Taiwan: Data suggest that an SNP in CHN2 (rs1002630) is associated with non-proliferative diabetic retinopathy in patients with diabetes type 2 in the Han Chinese population studied. | Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients.
Chen M, Lin WR, Lu CH, Chen CC, Huang YC, Liao WL, Tsai FJ. | 02/14/2015 |
| A significant association of the novel rs186911567 polymorphism was found for the CHN2 gene with smoking. | Association of a novel polymorphism of the β2-chimaerin gene (CHN2) with smoking.
Barrio-Real L, Barrueco M, González-Sarmiento R, Caloca MJ. | 07/19/2014 |
| genetic association studies in a Chinese population with type 2 diabetes: An SNP in CHN2 (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients. | CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.
Hu C, Zhang R, Yu W, Wang J, Wang C, Pang C, Ma X, Bao Y, Xiang K, Jia W., Free PMC Article | 12/17/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A Bayesian approach to genetic association studies with family-based designs.
Naylor MG, Weiss ST, Lange C., Free PMC Article | 12/5/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation | A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.
Griner EM, Caino MC, Sosa MS, Colón-González F, Chalmers MJ, Mischak H, Kazanietz MG., Free PMC Article | 06/28/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGeneralist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.
Docherty SJ, Kovas Y, Petrill SA, Plomin R. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.
Maeda S, Araki S, Babazono T, Toyoda M, Umezono T, Kawai K, Imanishi M, Uzu T, Watada H, Suzuki D, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Nakamura Y. Mutation of ARHGAP9 in patients with coronary spastic angina.
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K. | 01/20/2010 |
| Likely digenic cause of insulin resistance and growth deficiency resulting from the combined heterozygous disruption of INSR and CHN2, implicating CHN2 for the first time as a key element of proximal insulin signaling in vivo. | Severe insulin resistance and intrauterine growth deficiency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism.
Suliman SG, Stanik J, McCulloch LJ, Wilson N, Edghill EL, Misovicova N, Gasperikova D, Sandrikova V, Elliott KS, Barak L, Ellard S, Volpi EV, Klimes I, Gloyn AL., Free PMC Article | 01/21/2010 |
| Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C., Free PMC Article | 12/2/2009 |
| Tyr-153 is the Lck-dependent phosphorylation residue and its phosphorylation negatively regulates membrane stabilization of beta2-chimaerin, decreasing its GAP activity to Rac | T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells.
Siliceo M, Mérida I., Free PMC Article | 01/21/2010 |
| results suggest that beta2-chimaerin is activated by EphA receptors and mediates the EphA receptor-dependent regulation of cell migration | Beta2-chimaerin binds to EphA receptors and regulates cell migration.
Takeuchi S, Yamaki N, Iwasato T, Negishi M, Katoh H. | 01/21/2010 |
| Identify chimaerins as candidates for the downmodulation of Rac1 in T-lymphocytes and, in addition, uncover a novel regulatory mechanism that mediates their activation in T-cells. | Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.
Caloca MJ, Delgado P, Alarcón B, Bustelo XR., Free PMC Article | 01/21/2010 |
| the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin is induced synergistically by Phorbol ester and hydrogen peroxide | Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin.
Yasuda S, Kai M, Imai S, Kanoh H, Sakane F. | 01/21/2010 |
| results suggest Tyr-21 phosphorylation of beta2-chimaerin as a novel, Src-family kinase-dependent mechanism that negatively regulates beta2-chimaerin Rac-GAP activity | Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity.
Kai M, Yasuda S, Imai S, Kanoh H, Sakane F. | 01/21/2010 |
| beta 2 chimerin has a role in rac-GAP-dependent inhibition of breast cancer cell proliferation | Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.
Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG. | 01/21/2010 |
| Beta2-chimaerin regulates the proliferation and migration of vascular smooth muscle cells downstream of growth factor signaling pathway implicating human atherogenesis. | Regulation of vascular smooth muscle proliferation and migration by beta2-chimaerin, a non-protein kinase C phorbol ester receptor.
Maeda M, Kato S, Fukushima S, Kaneyuki U, Fujii T, Kazanietz MG, Oshima K, Shigemori M. | 01/21/2010 |
| Data demonstrate that beta2-chimaerin provides a novel, diacylglycerol-dependent mechanism for Rac regulation in T cells and suggest a functional role for this protein in Rac-mediated cytoskeletal remodeling. | Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells.
Siliceo M, García-Bernal D, Carrasco S, Díaz-Flores E, Coluccio Leskow F, Teixidó J, Kazanietz MG, Mérida I. | 01/21/2010 |