| Gene expression and DNA methylation analyses suggest that immune process-related ADCY6 is a prognostic factor of luminal-like breast cancer. | Gene expression and DNA methylation analyses suggest that immune process-related ADCY6 is a prognostic factor of luminal-like breast cancer.
Li W, Sang M, Hao X, Jia L, Wang Y, Shan B. | 08/7/2021 |
| Expanding the clinical and molecular spectrum of lethal congenital contracture syndrome 8 associated with biallelic variants of ADCY6. | Expanding the clinical and molecular spectrum of lethal congenital contracture syndrome 8 associated with biallelic variants of ADCY6.
Agolini E, Cherchi C, Bellacchio E, Martinelli D, Cocciadiferro D, Cutrera R, Chiarini Testa MB, Barone C, Bianca S, Novelli A. | 06/5/2021 |
| Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by beta-2 Adrenoceptors in Human Airway Smooth-Muscle Cells | Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by β-2 Adrenoceptors in Human Airway Smooth-Muscle Cells.
Agarwal SR, Fiore C, Miyashiro K, Ostrom RS, Harvey RD., Free PMC Article | 12/28/2019 |
| Data found that direct binding of 4.1G to the N-terminus of AC6 (AC6-N) contributes to the plasma membrane association of AC6-N and the resulting suppression of AC6 cyclase activity. | Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G.
Saito M, Cui L, Hirano M, Li G, Yanagisawa T, Sato T, Sukegawa J. | 12/21/2019 |
| PDE8 is expressed in lipid rafts of human airway smooth muscle cells(HASM), where it specifically regulates beta2-adrenergic receptor/ AC6 signaling to modulate HASM responsiveness and airway remodeling in asthma. | PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6.
Johnstone TB, Smith KH, Koziol-White CJ, Li F, Kazarian AG, Corpuz ML, Shumyatcher M, Ehlert FJ, Himes BE, Panettieri RA Jr, Ostrom RS., Free PMC Article | 07/13/2019 |
| rs3730071G/T and rs77913913G/T of ADCY6 were non-polymorphic with respect to HAPE. | Elevated Vasodilatory Cyclases and Shorter Telomere Length Contribute to High-Altitude Pulmonary Edema.
Rain M, Chaudhary H, Kukreti R, Thinlas T, Mohammad G, Pasha Q. | 12/22/2018 |
| model suggests Cys1004 in AC6 (subunit C2) and Cys174 in Galphas present at the AC-Galphas interface as the possible residues that might undergo reversible nitrosylation. Docking analysis predicted novel ligands of AC6 that include forskolin-based compounds and its derivatives. | Study of adenylyl cyclase-GαS interactions and identification of novel AC ligands.
Jaggupilli A, Dhanaraj P, Pritchard A, Sorensen JL, Dakshinamurti S, Chelikani P. | 11/3/2018 |
| Sickle cell anemia patients carrying at least one allele of adcy6 rs3730070-G exhibited lower hemolytic rate than non-carriers in univariate analysis (p=0.006). | Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia.
Cita KC, Ferdinand S, Connes P, Brudey L, Tressières B, Etienne-Julan M, Lemonne N, Tarer V, Elion J, Romana M. | 01/14/2017 |
| LRs are essential not only for the proper membrane distribution and maintenance of AC5/6 activity but also for the regulation of D1R- and D5R-mediated AC signaling. | Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.
Yu P, Sun M, Villar VA, Zhang Y, Weinman EJ, Felder RA, Jose PA., Free PMC Article | 05/16/2015 |
| Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects | Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects.
Laquérriere A, Maluenda J, Camus A, Fontenas L, Dieterich K, Nolent F, Zhou J, Monnier N, Latour P, Gentil D, Héron D, Desguerres I, Landrieu P, Beneteau C, Delaporte B, Bellesme C, Baumann C, Capri Y, Goldenberg A, Lyonnet S, Bonneau D, Estournet B, Quijano-Roy S, Francannet C, Odent S, Saint-Frison MH, Sigaudy S, Figarella-Branger D, Gelot A, Mussini JM, Lacroix C, Drouin-Garraud V, Malinge MC, Attié-Bitach T, Bessieres B, Bonniere M, Encha-Razavi F, Beaufrère AM, Khung-Savatovsky S, Perez MJ, Vasiljevic A, Mercier S, Roume J, Trestard L, Saugier-Veber P, Cordier MP, Layet V, Legendre M, Vigouroux-Castera A, Lunardi J, Bayes M, Jouk PS, Rigonnot L, Granier M, Sternberg D, Warszawski J, Gut I, Gonzales M, Tawk M, Melki J. | 12/20/2014 |
| AC6 localizes in lipid raft fractions of bronchial airway smooth muscle where it is stimulated by beta2 adrenergic- and prostacyclin receptors and inhibited by divalent calcium ions. | Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.
Bogard AS, Xu C, Ostrom RS., Free PMC Article | 05/21/2011 |
| In addition to its direct effect on renin gene transcription, PPARgamma "sensitizes" renin gene to cAMP via trans-activation of AC6 gene. | PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression.
Desch M, Schubert T, Schreiber A, Mayer S, Friedrich B, Artunc F, Todorov VT., Free PMC Article | 02/5/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Increased blood pressure and hyperdynamic cardiovascular responses in carriers of a common hyperfunctional variant of adenylyl cyclase 6.
Hodges GJ, Gros R, Hegele RA, Van Uum S, Shoemaker JK, Feldman RD. | 09/15/2010 |
| Instead the knock down of the predominant subtype AC6 in HUVECs provided the first direct evidence that the Ca(2+)-mediated inhibition of AC6 accounts for the thrombin-induced decrease in cAMP levels. | Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6.
Werthmann RC, von Hayn K, Nikolaev VO, Lohse MJ, Bünemann M., Free PMC Article | 01/21/2010 |
| The catalytic domains (C1 and C2) of adenylate cyclase 6 play a role in targeting adenylate cyclase 6 to lipid rafts. | The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae.
Thangavel M, Liu X, Sun SQ, Kaminsky J, Ostrom RS., Free PMC Article | 01/21/2010 |
| Parathyroid hormone communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3). | Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP.
Tovey SC, Dedos SG, Taylor EJ, Church JE, Taylor CW., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.
Ikoma E, Tsunematsu T, Nakazawa I, Shiwa T, Hibi K, Ebina T, Mochida Y, Toya Y, Hori H, Uchino K, Minamisawa S, Kimura K, Umemura S, Ishikawa Y, Ikoma E, Tsunematsu T, Nakazawa I, Shiwa T, Hibi K, Ebina T, Mochida Y, Toya Y, Hori H, Uchino K, Minamisawa S, Kimura K, Umemura S, Ishikawa Y. | 03/13/2008 |
| Expression of a novel, relatively common variant of ADCY6 parallels an increase in adenylyl cyclase activity and adenylyl cyclase-mediated function in humans. | Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6.
Gros R, Van Uum S, Hutchinson-Jaffe A, Ding Q, Pickering JG, Hegele RA, Feldman RD. | 01/21/2010 |
| Raf1 potentiates drug-stimulated cyclic AMP accumulation in cells expressing adenyl cyclcase 6 after activation of multiple signaling pathways. | Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells.
Beazely MA, Alan JK, Watts VJ. | 01/21/2010 |
| AC6 overexpression in endothelial cells may have use as a means to enhance prostacyclin function and reduce endothelial barrier permeability. | Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function.
Bundey RA, Insel PA. | 01/21/2010 |
| G protein betagamma subunits stimulate type V and VI adenylyl cyclases | Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.
Gao X, Sadana R, Dessauer CW, Patel TB. | 01/21/2010 |
| identified a single nucleotide polymorphism that may play a role in developing left ventricular hypertrophy | Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.
Ikoma E, Tsunematsu T, Nakazawa I, Shiwa T, Hibi K, Ebina T, Mochida Y, Toya Y, Hori H, Uchino K, Minamisawa S, Kimura K, Umemura S, Ishikawa Y, Ikoma E, Tsunematsu T, Nakazawa I, Shiwa T, Hibi K, Ebina T, Mochida Y, Toya Y, Hori H, Uchino K, Minamisawa S, Kimura K, Umemura S, Ishikawa Y. | 01/21/2010 |
| expression of nodular ADCY6, but not ADCY3, was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules | Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules.
Celano M, Arturi F, Presta I, Bruno R, Scarpelli D, Calvagno MG, Cristofaro C, Bulotta S, Giannasio P, Sacco R, Filetti S, Russo D. | 01/21/2010 |
| Adenylyl cyclase V and adenylyl cyclase VI interacts with A-kinase anchoring protein 79 (AKAP79) in a complex that associates with protein kinase A forming a negative feedback loop that termporally regulates cAMP production. | Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.
Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD., Free PMC Article | 01/21/2010 |
| These data show that, in an animal model that mimics key aspects of clinical congestive heart failure, cardiac gene transfer of ACVI increases function of the failing heart. | Adenylylcyclase gene transfer increases function of the failing heart.
Rebolledo B, Lai NC, Gao MH, Takahashi T, Roth DM, Baird SM, Hammond HK. | 01/21/2010 |