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    PTENP1 phosphatase and tensin homolog pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 11191, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters.

    Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters.
    Záveský L, Jandáková E, Weinberger V, Minář L, Kohoutová M, Slanař O., Free PMC Article

    08/16/2024
    Role and the molecular mechanism of lncRNA PTENP1 in regulating the proliferation and invasion of cervical cancer cells.

    Role and the molecular mechanism of lncRNA PTENP1 in regulating the proliferation and invasion of cervical cancer cells.
    Wu C, Wang F, Tan L.

    08/27/2022
    Rs7853346 Polymorphism in lncRNA-PTENP1 and rs1799864 Polymorphism in CCR2 are Associated with Radiotherapy-Induced Cognitive Impairment in Subjects with Glioma Via Regulating PTENP1/miR-19b/CCR2 Signaling Pathway.

    Rs7853346 Polymorphism in lncRNA-PTENP1 and rs1799864 Polymorphism in CCR2 are Associated with Radiotherapy-Induced Cognitive Impairment in Subjects with Glioma Via Regulating PTENP1/miR-19b/CCR2 Signaling Pathway.
    Yang S, Fu ZZ, Zhang YQ, Fu BH, Dong LX.

    07/16/2022
    Studying the Oncosuppressive Functions of PTENP1 as a ceRNA.

    Studying the Oncosuppressive Functions of PTENP1 as a ceRNA.
    Travis G, Haddadi N, Simpson AM, Marsh DJ, McGowan EM, Nassif NT.

    10/9/2021
    PTENP1 is a ceRNA for PTEN: it's CRISPR clear.

    PTENP1 is a ceRNA for PTEN: it's CRISPR clear.
    Vitiello M, Evangelista M, Zhang Y, Salmena L, Pandolfi PP, Poliseno L., Free PMC Article

    05/22/2021
    Methylation of the PTENP1 pseudogene as potential epigenetic marker of age-related changes in human endometrium.

    Methylation of the PTENP1 pseudogene as potential epigenetic marker of age-related changes in human endometrium.
    Kovalenko TF, Morozova KV, Pavlyukov MS, Anufrieva KS, Bobrov MY, Gamisoniya AM, Ozolinya LA, Dobrokhotova YE, Shakhparonov MI, Patrushev LI., Free PMC Article

    04/24/2021
    Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.

    Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.
    Kerwin J, Khan I, Reproducibility Project: Cancer Biology., Free PMC Article

    04/3/2021
    Reduced long non-coding RNA PTENP1 contributed to proliferation and invasion via miR-19b/MTUS1 axis in patients with cervical cancer.

    Reduced long non-coding RNA PTENP1 contributed to proliferation and invasion via miR-19b/MTUS1 axis in patients with cervical cancer.
    Ou L, Xiang TY, Hao XY, Wang DZ, Zeng Q.

    04/3/2021
    Pseudogene PTENP1 sponges miR-214 to regulate the expression of PTEN to modulate osteoclast differentiation and attenuate osteoporosis.

    Pseudogene PTENP1 sponges miR-214 to regulate the expression of PTEN to modulate osteoclast differentiation and attenuate osteoporosis.
    Wang CG, Wang L, Yang T, Su SL, Hu YH, Zhong D.

    02/20/2021
    Long noncoding RNA PTENP1 affects the recovery of spinal cord injury by regulating the expression of miR-19b and miR-21.

    Long noncoding RNA PTENP1 affects the recovery of spinal cord injury by regulating the expression of miR-19b and miR-21.
    Wang Z, Song Y, Han X, Qu P, Wang W.

    02/6/2021
    G allele of rs7853346 polymorphism in PTENP1 enhances the proliferation of multiple myeloma cancer stem cells by promoting the expression of PTENP1 and its downstream signaling molecules.

    G allele of rs7853346 polymorphism in PTENP1 enhances the proliferation of multiple myeloma cancer stem cells by promoting the expression of PTENP1 and its downstream signaling molecules.
    Zhang Y, Xu C.

    11/21/2020
    LncRNA PTENP1 inhibits cervical cancer progression by suppressing miR-106b.

    LncRNA PTENP1 inhibits cervical cancer progression by suppressing miR-106b.
    Fan Y, Sheng W, Meng Y, Cao Y, Li R.

    10/24/2020
    hUC-MSCs secreted exosomes inhibit the glioma cell progression through PTENP1/miR-10a-5p/PTEN pathway.

    hUC-MSCs secreted exosomes inhibit the glioma cell progression through PTENP1/miR-10a-5p/PTEN pathway.
    Hao SC, Ma H, Niu ZF, Sun SY, Zou YR, Xia HC.

    10/24/2020
    Pseudogene PTENP1 facilitates PTEN expression in smooth muscle cells derived from patients with aortic aneurysms by competitively sponging miR-21.

    The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA.
    Lai Y, Li J, Zhong L, He X, Si X, Sun Y, Chen Y, Zhong J, Hu Y, Li B, Liao W, Liu C, Liao Y, Xiu J, Bin J.

    03/28/2020
    PTENP1/miR-20a/PTEN axis involved in the malignant behaviors of BC cells, illuminating the possible mechanism mediated by PTEN via PI3K/Akt pathway. Targeting PTENP1/miR-20a/PTEN may provide a potential diagnosis and treatment strategy for BC.

    PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway.
    Gao X, Qin T, Mao J, Zhang J, Fan S, Lu Y, Sun Z, Zhang Q, Song B, Li L., Free PMC Article

    12/7/2019
    PTENP1 rs7853346 is statistically correlated with the oral squamous cell carcinoma (OSCC) risk.

    Polymorphisms in lncRNA PTENP1 and the risk of oral squamous cell carcinoma in a Chinese population.
    Xin C, Li JL, Zhang YX, Yu ZH.

    11/16/2019
    it can be concluded that estrogen improves the miR-200c level by combining with ER, PTENP1 and PTEN could be inhibited by miR-200c, and then activate the PI3K-AKT pathway.

    Estrogen affects the negative feedback loop of PTENP1-miR200c to inhibit PTEN expression in the development of endometrioid endometrial carcinoma.
    Chen R, Zhang M, Liu W, Chen H, Cai T, Xiong H, Sheng X, Liu S, Peng J, Wang F, Chen H, Lin W, Xu X, Zheng W, Jiang Q., Free PMC Article

    11/16/2019
    our results indicated that exosomal PTENP1 was a promising novel biomarker for diagnosis of bladder cancer.

    Exosome-transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression.
    Zheng R, Du M, Wang X, Xu W, Liang J, Wang W, Lv Q, Qin C, Chu H, Wang M, Yuan L, Qian J, Zhang Z., Free PMC Article

    04/27/2019
    High PTENP1 expression is associated with Cellular Proliferation and Invasion in Breast Cancer.

    Overexpression of Long Noncoding RNA PTENP1 Inhibits Cell Proliferation and Migration via Suppression of miR-19b in Breast Cancer Cells.
    Shi X, Tang X, Su L., Free PMC Article

    02/9/2019
    While PTENP1 upregulation decreased PTEN transcript levels and stimulated the growth of ER-positive breast cancers, increased PTEN transcript levels and inhibited tumor progression was observed in the ER-negative cells.

    Divergent Activity of the Pseudogene PTENP1 in ER-Positive and Negative Breast Cancer.
    Yndestad S, Austreid E, Skaftnesmo KO, Lønning PE, Eikesdal HP.

    01/19/2019
    Study shows that decreased expression of pseudogene PTENP1 promotes malignant behaviours and is associated with the poor survival of patients with head and neck squamous cell carcinoma.

    Decreased expression of pseudogene PTENP1 promotes malignant behaviours and is associated with the poor survival of patients with HNSCC.
    Liu J, Xing Y, Xu L, Chen W, Cao W, Zhang C., Free PMC Article

    11/3/2018
    A potentially functional lncRNA PTENP1 tagSNP (rs7853346 C>G) reduced the susceptibility to gastric cancer in a Chinese population.

    Polymorphisms in lncRNA PTENP1 and the Risk of Gastric Cancer in a Chinese Population.
    Ge Y, He Y, Jiang M, Luo D, Huan X, Wang W, Zhang D, Yang L, Zhou J., Free PMC Article

    07/7/2018
    upregualtion of PTENP1 could attenuate BC cell growth and metastasis, and induce apoptosis, possibly because it has a competing endogenous RNA role in reverse regulation of miRNA-19b, and then activation of PTEN, as well as modulation of PTEN/AKT/p53 signaling pathway

    PTENP1 acts as a ceRNA to regulate PTEN by sponging miR-19b and explores the biological role of PTENP1 in breast cancer.
    Li RK, Gao J, Guo LH, Huang GQ, Luo WH.

    04/28/2018
    we revealed a tumor suppressive role of PTENP1 as ceRNA in GC and pinpointed the specific miRNAs decoyed by PTENP1, highlighting the emerging roles of ceRNAs in the biological regulation of GC cells and their possible clinical significance.

    Long non-coding RNA PTENP1 functions as a ceRNA to modulate PTEN level by decoying miR-106b and miR-93 in gastric cancer.
    Zhang R, Guo Y, Ma Z, Ma G, Xue Q, Li F, Liu L., Free PMC Article

    03/10/2018
    Results indicate that similar to PTEN pseudogene (PTENP1), suppressor of cytokine signaling 6 protein (SOCS6) expression was also significantly lower in esophageal squamous cell carcinoma (ESCC) samples.

    PTENP1 inhibits the growth of esophageal squamous cell carcinoma by regulating SOCS6 expression and correlates with disease prognosis.
    Gong T, Zheng S, Huang S, Fu S, Zhang X, Pan S, Yang T, Sun Y, Wang Y, Hui B, Guo J, Zhang X., Free PMC Article

    12/9/2017
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