| Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer. | Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer.
Liu Y, Wang J, Guo J, Zhang Q, Wang S, Hu F, Wu J, Zhao Y, Zhang J, Yu Y, Li Y, Zhang X., Free PMC Article | 03/6/2024 |
| Nasopharyngeal carcinoma derived exosomes regulate the proliferation and migration of nasopharyngeal carcinoma cells by mediating the miR-99a-5p BAZ2A axis. | Nasopharyngeal carcinoma derived exosomes regulate the proliferation and migration of nasopharyngeal carcinoma cells by mediating the miR-99a-5p BAZ2A axis.
Zhou XJ, Xu HM, Huang GS, Lin BR., Free PMC Article | 01/30/2024 |
| BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer. | BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer.
Roganowicz M, Bär D, Bersaglieri C, Aprigliano R, Santoro R., Free PMC Article | 05/24/2023 |
| BAZ2A-mediated repression via H3K14ac-marked enhancers promotes prostate cancer stem cells. | BAZ2A-mediated repression via H3K14ac-marked enhancers promotes prostate cancer stem cells.
Peña-Hernández R, Aprigliano R, Carina Frommel S, Pietrzak K, Steiger S, Roganowicz M, Lerra L, Bizzarro J, Santoro R., Free PMC Article | 03/19/2022 |
| Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status. | Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status.
Chen S, Zhou M, Dong A, Loppnau P, Wang M, Min J, Liu K., Free PMC Article | 01/29/2022 |
| the results of the present study demonstrated that TIP5 regulates beta-catenin/TCF7L2 signaling via TIP5 during HCC progression and suggests that TIP5 may be a promising therapeutic target for the treatment of HCC. | The transcription factor 7 like 2‑binding protein TIP5 activates β‑catenin/transcription factor signaling in hepatocellular carcinoma.
Li C, Wu W, Ding H, Li Q, Xie K., Free PMC Article | 09/29/2018 |
| Data suggest that binding of helical tail of histone 3 (H3) with PHD ('plant homeodomain') fingers of BAZ2A or BAZ2B (bromodomain adjacent to zinc finger domain 2A or 2B) requires molecular recognition of secondary structure motifs within H3 tail and could represent an additional layer of regulation in epigenetic processes. | Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.
Bortoluzzi A, Amato A, Lucas X, Blank M, Ciulli A., Free PMC Article | 06/24/2017 |
| Data show that SUMOylated BANP, E5R, and Nac1 (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1-interacting protein 5 (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase | BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.
Khan A, Giri S, Wang Y, Chakraborty A, Ghosh AK, Anantharaman A, Aggarwal V, Sathyan KM, Ha T, Prasanth KV, Prasanth SG., Free PMC Article | 10/31/2015 |
| Crystal structures of PHD zinc finger and bromodomains from human TIP5 and BAZ2B in free form and bound to H3 and/or H4 histones. | Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.
Tallant C, Valentini E, Fedorov O, Overvoorde L, Ferguson FM, Filippakopoulos P, Svergun DI, Knapp S, Ciulli A., Free PMC Article | 10/3/2015 |
| The study showed that the NMR structure of the TAM domain of TIP5 resembles the fold of the MBD domain, found in methyl-CpG binding proteins. | A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.
Anosova I, Melnik S, Tripsianes K, Kateb F, Grummt I, Sattler M., Free PMC Article | 08/22/2015 |
| association with ribosomal DNA is impaired in embryonic stem cells and occurs upon cell differentiation | lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs.
Savić N, Bär D, Leone S, Frommel SC, Weber FA, Vollenweider E, Ferrari E, Ziegler U, Kaech A, Shakhova O, Cinelli P, Santoro R. | 08/1/2015 |
| BAZ2A is overexpressed in prostate cancer, maintains its cell growth, regulates protein-coding genes, and interacts with EZH2 to silence genes repressed in metastasis. Its overexpression is associated with a CpG island methylator phenotype. | BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence.
Gu L, Frommel SC, Oakes CC, Simon R, Grupp K, Gerig CY, Bär D, Robinson MD, Baer C, Weiss M, Gu Z, Schapira M, Kuner R, Sültmann H, Provenzano M, ICGC Project on Early Onset Prostate Cancer, Yaspo ML, Brors B, Korbel J, Schlomm T, Sauter G, Eils R, Plass C, Santoro R. | 03/21/2015 |
| High BAZ2A expression is associated with pancreatic cancer. | Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.
Ansari D, Andersson R, Bauden MP, Andersson B, Connolly JB, Welinder C, Sasor A, Marko-Varga G. | 03/21/2015 |
| Data show that MOF acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that SIRT1 (removes the acetyl group from K633. | Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.
Zhou Y, Schmitz KM, Mayer C, Yuan X, Akhtar A, Grummt I. | 01/21/2010 |
| the apparent occurrence of an unusual TG 3' splice site in intron 1 is discussed | Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M., Free PMC Article | 10/4/2007 |