| The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth. | The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth.
Qian J, Ma Y, Tahaney WM, Moyer CL, Lanier A, Hill J, Coleman D, Koupaei N, Hilsenbeck SG, Savage MI, Page BDG, Mazumdar A, Brown PH., Free PMC Article | 03/11/2024 |
| NUDT5-Determines the fate of head and neck squamous cell carcinoma cells under endoplasmic reticulum stress by catalyzing nuclear ATP production to promote DNA repair. | NUDT5-Determines the fate of head and neck squamous cell carcinoma cells under endoplasmic reticulum stress by catalyzing nuclear ATP production to promote DNA repair.
Ding H, Wu C, Sun W, Zhan Q, Huang Y, Liao N, Jiang Z, Wang K, Li Y. | 05/23/2023 |
| Silencing of Nudix type 5 represses proliferation and invasion and enhances chemosensitivity of gastric carcinoma cells by affecting the AKT/GSK-3beta/beta-catenin pathway. | Silencing of Nudix type 5 represses proliferation and invasion and enhances chemosensitivity of gastric carcinoma cells by affecting the AKT/GSK-3β/β-catenin pathway.
Tan D, Zhang Y. | 05/7/2022 |
| The high expression of NUDT5 indicates poor prognosis of breast cancer by modulating AKT / Cyclin D signaling. | The high expression of NUDT5 indicates poor prognosis of breast cancer by modulating AKT / Cyclin D signaling.
Zhang H, Zhang LQ, Yang CC, Li J, Tian XY, Li DN, Cui J, Cai JP., Free PMC Article | 07/31/2021 |
| The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer. | The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.
Li DN, Yang CC, Li J, Ou Yang QG, Zeng LT, Fan GQ, Liu TH, Tian XY, Wang JJ, Zhang H, Dai DP, Cui J, Cai JP. | 04/17/2021 |
| Data suggest that targeting nudix hydrolase 5 (NUDT5) may represent a promising new therapeutic approach for breast cancer treatment. | Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page BDG, Valerie NCK, Wright RHG, Wallner O, Isaksson R, Carter M, Rudd SG, Loseva O, Jemth AS, Almlöf I, Font-Mateu J, Llona-Minguez S, Baranczewski P, Jeppsson F, Homan E, Almqvist H, Axelsson H, Regmi S, Gustavsson AL, Lundbäck T, Scobie M, Strömberg K, Stenmark P, Beato M, Helleday T., Free PMC Article | 03/3/2018 |
| In the presence of pyrophosphate, ADP-ribose is used by the pyrophosphatase NUDIX5 to generate nuclear ATP. | ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.
Wright RH, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J, Nacht AS, Samino S, Font-Mateu J, Vicent GP, Wierer M, Trabado MA, Schelhorn C, Carolis C, Macias MJ, Yanes O, Oliva B, Beato M. | 07/2/2016 |
| The NUDT5 protein could play significant roles in the prevention of RNA oxidation and survival in human fibroblast cells. | Lowered Nudix type 5 expression leads to cellular senescence in IMR-90 fibroblast cells.
Zhang L, Song XN, Dai DP, Zhou XY, Gan W, Takagi Y, Hayakawa H, Sekiguchi M, Cai JP. | 09/27/2014 |
| Results suggest that the NUDT5 protein may play significant roles in regulating the G1-S transition in HeLa cells. | Lowered nudix type 5 (NUDT5) expression leads to cell cycle retardation in HeLa cells.
Zhang LQ, Dai DP, Gan W, Takagi Y, Hayakawa H, Sekiguchi M, Cai JP. | 07/7/2012 |
| The human NUDT5, which has an intrinsic activity to cleave ADP sugars to AMP and sugar phosphate, possesses the ability to degrade 8-oxo-dGDP to the monophosphate. | Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein.
Ito R, Sekiguchi M, Setoyama D, Nakatsu Y, Yamagata Y, Hayakawa H. | 02/4/2012 |
| The broad substrate specificity of hNUDT5 is achieved by a diversity of not only substrate recognition, but also hydrolysis mechanisms. | Diverse substrate recognition and hydrolysis mechanisms of human NUDT5.
Arimori T, Tamaoki H, Nakamura T, Kamiya H, Ikemizu S, Takagi Y, Ishibashi T, Harashima H, Sekiguchi M, Yamagata Y., Free PMC Article | 01/21/2012 |
| human MTH1, MTH2, and NUDT5 proteins act as a defense against the mutagenesis induced by oxidized dGTP. | Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5.
Hori M, Satou K, Harashima H, Kamiya H. | 06/28/2010 |
| NUDT5 protein eliminates various oxidized deoxyribonucleoside diphosphates from the nucleotide pool and prevents their toxic effects. | NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity.
Kamiya H, Hori M, Arimori T, Sekiguchi M, Yamagata Y, Harashima H. | 01/25/2010 |
| Results report the crystal structure of hNUDT5 in complex with a non-hydrolyzable ADPR analogue, alpha,beta-methyleneadenosine diphosphoribose, and three Mg(2+) ions representing the transition state of the enzyme during catalysis. | Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.
Zha M, Guo Q, Zhang Y, Yu B, Ou Y, Zhong C, Ding J. | 01/21/2010 |
| degrades 8-oxo-dGDP to 8-oxo-dGMP, an unusable form for DNA synthesis, and promotes the cleavage of 8-oxo-dGTP by MTH1 to yield 8-oxo-dGMP also | A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.
Ishibashi T, Hayakawa H, Sekiguchi M., Free PMC Article | 01/21/2010 |