| HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway. | HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway.
Wang J, Yang K, Yang X, Jin T, Tian Y, Dai C, Xu F. | 07/11/2024 |
| HHLA2 deficiency inhibits pancreatic cancer progression and THP-1 macrophage M2 polarization via EGFR/MAPK/ERK and mTOR/AKT pathway. | HHLA2 deficiency inhibits pancreatic cancer progression and THP-1 macrophage M2 polarization via EGFR/MAPK/ERK and mTOR/AKT pathway.
Zhou S, Wang Z, Zhao D, Fu Y, Zhang S, Wang Z, Zou X., Free PMC Article | 05/24/2024 |
| HHLA2 is more significantly associated with poor prognosis in TSCC than PD-L1. | HHLA2 is more significantly associated with poor prognosis in TSCC than PD-L1.
Li Y, Yang Q, Yang X, Ge J, Xu T, Liu H. | 02/27/2024 |
| Regulation of HHLA2 expression in kidney cancer and myeloid cells. | Regulation of HHLA2 expression in kidney cancer and myeloid cells.
Shigemura T, Perrot N, Huang Z, Bhatt RS, Sheshdeh AB, Ahmar NE, Ghandour F, Signoretti S, McDermott DF, Freeman GJ, Mahoney KM., Free PMC Article | 11/1/2023 |
| HHLA2 immune-regulatory roles in cancer. | HHLA2 immune-regulatory roles in cancer.
Mortezaee K. | 07/19/2023 |
| KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in immune responses and its potential therapeutic approach for cancer immunotherapy. | KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in immune responses and its potential therapeutic approach for cancer immunotherapy.
Li Y, Lv C, Yu Y, Wu B, Zhang Y, Lang Q, Liang Z, Zhong C, Shi Y, Han S, Xu F, Tian Y., Free PMC Article | 05/4/2023 |
| Overexpression and Role of HHLA2, a Novel Immune Checkpoint, in Colorectal Cancer. | Overexpression and Role of HHLA2, a Novel Immune Checkpoint, in Colorectal Cancer.
Kula A, Dawidowicz M, Mielcarska S, Kiczmer P, Skiba H, Krygier M, Chrabańska M, Piecuch J, Szrot M, Robotycka J, Ochman B, Strzałkowska B, Czuba Z, Świętochowska E, Waniczek D., Free PMC Article | 03/31/2023 |
| Increased co-expression of stromal HHLA2 and fibroblast activation protein in upper tract urothelial carcinoma. | Increased co-expression of stromal HHLA2 and fibroblast activation protein in upper tract urothelial carcinoma.
Nishihara D, Kijima T, Arai K, Kamai T., Free PMC Article | 03/24/2023 |
| Decrease of Membrane B7-H5 on CD14+ Cells in Severe Acute Pancreatitis Is Related to RANSON Scores and APACHE II Scores. | Decrease of Membrane B7-H5 on CD14+ Cells in Severe Acute Pancreatitis Is Related to RANSON Scores and APACHE II Scores.
Xu R, Xie S, Gong J, Chen W, Jin Y, Huang J. | 03/16/2023 |
| Immunosuppression by Inflammation-Stimulated Amplification of Myeloid-Derived Suppressor Cells and Changes in Expression of Immune Checkpoint HHLA2 in Chronic Obstructive Pulmonary Disease. | Immunosuppression by Inflammation-Stimulated Amplification of Myeloid-Derived Suppressor Cells and Changes in Expression of Immune Checkpoint HHLA2 in Chronic Obstructive Pulmonary Disease.
Xu L, Li F, Jiang M, Li Z, Xu D, Jing J, Wang J, Ding J., Free PMC Article | 03/2/2023 |
| Silencing tumor-intrinsic HHLA2 potentiates the anti-tumoral effect of paclitaxel on MG63 cells: Another side of immune checkpoint. | Silencing tumor-intrinsic HHLA2 potentiates the anti-tumoral effect of paclitaxel on MG63 cells: Another side of immune checkpoint.
Ahangar NK, Khalaj-Kondori M, Alizadeh N, Mokhtarzadeh A, Baghbanzadeh A, Shadbad MA, Dolatkhah K, Baradaran B. | 02/4/2023 |
| HHLA2 predicts improved prognosis of anti-PD-1/PD-L1 immunotherapy in patients with melanoma. | HHLA2 predicts improved prognosis of anti-PD-1/PD-L1 immunotherapy in patients with melanoma.
Huang FX, Wu JW, Cheng XQ, Wang JH, Wen XZ, Li JJ, Zhang Q, Jiang H, Ding QY, Zhu XF, Zhang XS, Ding Y, Li DD., Free PMC Article | 09/3/2022 |
| HHLA2 promotes tumor progression by long noncoding RNA H19 in human gallbladder cancer. | HHLA2 promotes tumor progression by long non‑coding RNA H19 in human gallbladder cancer.
Zhang Y, Li H, Lv C, Wu B, Yu Y, Zhong C, Lang Q, Liang Z, Li Y, Shi Y, Zhang J, Xu F, Tian Y., Free PMC Article | 08/20/2022 |
| The methyltransferase METTL3 promotes tumorigenesis via mediating HHLA2 mRNA m6A modification in human renal cell carcinoma. | The methyltransferase METTL3 promotes tumorigenesis via mediating HHLA2 mRNA m6A modification in human renal cell carcinoma.
Zhu D, Liu Y, Chen J, Wang Q, Li Y, Zhu Y, Feng J, Jiang J., Free PMC Article | 07/23/2022 |
| High expression of HHLA2 predicts poor prognosis in medullary thyroid carcinoma. | High expression of HHLA2 predicts poor prognosis in medullary thyroid carcinoma.
Niu Y, Wang W, Jiang X, Huang Y, Yan S, Jiang Y. | 07/16/2022 |
| HHLA2 Immune Checkpoint Is a Novel Prognostic Predictor in Hepatocellular Carcinoma. | HHLA2 Immune Checkpoint Is a Novel Prognostic Predictor in Hepatocellular Carcinoma.
Liao X, Zhang D. | 07/9/2022 |
| HHLA2 Activates the JAK/STAT Signaling Pathway by Binding to TMIGD2 in Hepatocellular Carcinoma Cells. | HHLA2 Activates the JAK/STAT Signaling Pathway by Binding to TMIGD2 in Hepatocellular Carcinoma Cells.
Guo H, Zhang C, Tang X, Zhang T, Liu Y, Yu H, Li Y, Wang R. | 06/18/2022 |
| Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy. | Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy.
Ying H, Xu J, Zhang X, Liang T, Bai X., Free PMC Article | 05/21/2022 |
| Different clinical significance of novel B7 family checkpoints VISTA and HHLA2 in human lung adenocarcinoma. | Different clinical significance of novel B7 family checkpoints VISTA and HHLA2 in human lung adenocarcinoma.
Long L, Zhang L, Yang Y, Zhou Y, Chen H. | 05/7/2022 |
| Comprehensive Analysis of HHLA2 as a Prognostic Biomarker and Its Association With Immune Infiltrates in Hepatocellular Carcinoma. | Comprehensive Analysis of HHLA2 as a Prognostic Biomarker and Its Association With Immune Infiltrates in Hepatocellular Carcinoma.
Ding L, Yu Q, Yang S, Yang WJ, Liu T, Xian JR, Tian TT, Li T, Chen W, Wang BL, Pan BS, Zhou J, Fan J, Yang XR, Guo W., Free PMC Article | 04/16/2022 |
| Interferon Gamma-Induced Interferon Regulatory Factor 1 Activates Transcription of HHLA2 and Induces Immune Escape of Hepatocellular Carcinoma Cells. | Interferon Gamma-Induced Interferon Regulatory Factor 1 Activates Transcription of HHLA2 and Induces Immune Escape of Hepatocellular Carcinoma Cells.
Wang R, Guo H, Tang X, Zhang T, Liu Y, Zhang C, Yu H, Li Y. | 03/26/2022 |
| KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target. | KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target.
Wei Y, Ren X, Galbo PM Jr, Moerdler S, Wang H, Sica RA, Etemad-Gilbertson B, Shi L, Zhu L, Tang X, Lin Q, Peng M, Guan F, Zheng D, Chinai JM, Zang X., Free PMC Article | 03/12/2022 |
| Coexpression of HHLA2 and PD-L1 on Tumor Cells Independently Predicts the Survival of Spinal Chordoma Patients. | Coexpression of HHLA2 and PD-L1 on Tumor Cells Independently Predicts the Survival of Spinal Chordoma Patients.
Xia C, Huang W, Chen YL, Fu HB, Tang M, Zhang TL, Li J, Lv GH, Yan YG, Ouyang ZH, Yao N, Wang C, Zou MX., Free PMC Article | 03/5/2022 |
| HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization. | HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.
Sun W, Li S, Tang G, Sun S, Luo Y, Bai R, Han L, Jiang X, Gao Y, Huang Z, Zhang J, Gong Y, Xie C., Free PMC Article | 02/19/2022 |
| B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling. | B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.
Rieder SA, Wang J, White N, Qadri A, Menard C, Stephens G, Karnell JL, Rudd CE, Kolbeck R., Free PMC Article | 01/29/2022 |