| BTN3A1 expressed in cervical cancer cells promotes Vgamma9Vdelta2 T cells exhaustion through upregulating transcription factors NR4A2/3 downstream of TCR signaling. | BTN3A1 expressed in cervical cancer cells promotes Vγ9Vδ2 T cells exhaustion through upregulating transcription factors NR4A2/3 downstream of TCR signaling.
Liu J, Wu M, Yang Y, Mei X, Wang L, Wang J, Wang Z, He S, Liu H, Jiang H, Qu S, Zhang Y, Chen Y, Tian X, Huang Y, Wang H., Free PMC Article | 10/1/2024 |
| Association of BTN3A1 gene polymorphisms with systemic lupus erythematosus in a Chinese Han population. | Association of BTN3A1 gene polymorphisms with systemic lupus erythematosus in a Chinese Han population.
Xu WD, Yang C, Li R, Tang YY, Wang DC, Huang AF. | 03/14/2024 |
| Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis. | Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis.
Tang YY, Xu WD, Fu L, Liu XY, Huang AF. | 01/15/2024 |
| Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vgamma9Vdelta2 T cells. | Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells.
Yuan L, Ma X, Yang Y, Qu Y, Li X, Zhu X, Ma W, Duan J, Xue J, Yang H, Huang JW, Yi S, Zhang M, Cai N, Zhang L, Ding Q, Lai K, Liu C, Zhang L, Liu X, Yao Y, Zhou S, Li X, Shen P, Chang Q, Malwal SR, He Y, Li W, Chen C, Chen CC, Oldfield E, Guo RT, Zhang Y., Free PMC Article | 09/29/2023 |
| Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1. | Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1.
Nguyen K, Jin Y, Howell M, Hsiao CC, Wiemer AJ, Vinogradova O., Free PMC Article | 06/26/2023 |
| BTN3A1 promotes tumor progression and radiation resistance in esophageal squamous cell carcinoma by regulating ULK1-mediated autophagy. | BTN3A1 promotes tumor progression and radiation resistance in esophageal squamous cell carcinoma by regulating ULK1-mediated autophagy.
Yang W, Cheng B, Chen P, Sun X, Wen Z, Cheng Y., Free PMC Article | 12/3/2022 |
| BTN3A: A Promising Immune Checkpoint for Cancer Prognosis and Treatment. | BTN3A: A Promising Immune Checkpoint for Cancer Prognosis and Treatment.
Kone AS, Ait Ssi S, Sahraoui S, Badou A., Free PMC Article | 11/26/2022 |
| Up-regulation of BTN3A1 on CD14(+) cells promotes Vgamma9Vdelta2 T cell activation in psoriasis. | Up-regulation of BTN3A1 on CD14(+) cells promotes Vγ9Vδ2 T cell activation in psoriasis.
Zhou J, Zhang J, Tao L, Peng K, Zhang Q, Yan K, Luan J, Pan J, Su X, Sun J, Zhang Z, Shen L., Free PMC Article | 11/5/2022 |
| Elevated Expressions of BTN3A1 and RhoB in Psoriasis Vulgaris Lesions by an Immunohistochemical Study. | Elevated Expressions of BTN3A1 and RhoB in Psoriasis Vulgaris Lesions by an Immunohistochemical Study.
Tian Z, Wong W, Wu Q, Zhou J, Yan K, Chen J, Zhang Z. | 05/7/2022 |
| Comprehensive analysis of BTN3A1 in cancers: mining of omics data and validation in patient samples and cellular models. | Comprehensive analysis of BTN3A1 in cancers: mining of omics data and validation in patient samples and cellular models.
Liang F, Zhang C, Guo H, Gao SH, Yang FY, Zhou GB, Wang GZ., Free PMC Article | 04/2/2022 |
| Expression level of BTN3A1 on the surface of CD14(+) monocytes is a potential predictor of gammadelta T cell expansion efficiency. | Expression level of BTN3A1 on the surface of CD14(+) monocytes is a potential predictor of γδ T cell expansion efficiency.
Tomogane M, Omura M, Sano Y, Shimizu D, Toda Y, Hosogi S, Kimura S, Ashihara E. | 02/12/2022 |
| The intracellular domain of BTN2A1 binds to the intracellular domain of BTN3A1 only in the presence of phosphoantigen. | Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex.
Hsiao CC, Nguyen K, Jin Y, Vinogradova O, Wiemer AJ., Free PMC Article | 01/27/2022 |
| BTN3A1 governs antitumor responses by coordinating alphabeta and gammadelta T cells. | BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells.
Payne KK, Mine JA, Biswas S, Chaurio RA, Perales-Puchalt A, Anadon CM, Costich TL, Harro CM, Walrath J, Ming Q, Tcyganov E, Buras AL, Rigolizzo KE, Mandal G, Lajoie J, Ophir M, Tchou J, Marchion D, Luca VC, Bobrowicz P, McLaughlin B, Eskiocak U, Schmidt M, Cubillos-Ruiz JR, Rodriguez PC, Gabrilovich DI, Conejo-Garcia JR., Free PMC Article | 09/26/2020 |
| We identified four Type 1 diabetes (T1D) risk loci reaching genome-wide significance in the Chinese Han population, including two novel loci: rs4320356 near BTN3A1, rs3802604 in GATA3, and two previously reported loci: rs1770 in MHC and rs705699 in SUOX. A higher genetic risk score were associated with an earlier age of T1D diagnosis and lower fasting C-peptide levels in individuals newly diagnosed with T1D. | Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study.
Zhu M, Xu K, Chen Y, Gu Y, Zhang M, Luo F, Liu Y, Gu W, Hu J, Xu H, Xie Z, Sun C, Li Y, Sun M, Xu X, Hsu HT, Chen H, Fu Q, Shi Y, Xu J, Ji L, Liu J, Bian L, Zhu J, Chen S, Xiao L, Li X, Jiang H, Shen M, Huang Q, Fang C, Li X, Huang G, Fan J, Jiang Z, Jiang Y, Dai J, Ma H, Zheng S, Cai Y, Dai H, Zheng X, Zhou H, Ni S, Jin G, She JX, Yu L, Polychronakos C, Hu Z, Zhou Z, Weng J, Shen H, Yang T. | 04/18/2020 |
| this study identified butyrophilin 2A1 (BTN2A1) as a key ligand that binds to the Vgamma9(+) TCR gamma chain | Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells.
Rigau M, Ostrouska S, Fulford TS, Johnson DN, Woods K, Ruan Z, McWilliam HEG, Hudson C, Tutuka C, Wheatley AK, Kent SJ, Villadangos JA, Pal B, Kurts C, Simmonds J, Pelzing M, Nash AD, Hammet A, Verhagen AM, Vairo G, Maraskovsky E, Panousis C, Gherardin NA, Cebon J, Godfrey DI, Behren A, Uldrich AP. | 04/18/2020 |
| Despite maintaining surface expression, BTN3A1 mutagenesis either abrogated or decreased stimulation by (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate demonstrating that the coiled-coil domains of BTN3A1 play critical roles for its function. | Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human Vγ2Vδ2 T Cells.
Wang H, Nada MH, Tanaka Y, Sakuraba S, Morita CT., Free PMC Article | 04/18/2020 |
| Crystal structures of intracellular butyrophilin 3A proteins alone or in complex with the potent microbial phosphoantigen HMBPP or a synthetic analog revealed key features of phosphoantigens and butyrophilins required for gammadelta T cell activation. HMBPP binding to butyrophilin doubled the binding force between a gammadelta T cell and a target cell during "outside" signaling, as measured by single-cell force microsc... | A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation.
Yang Y, Li L, Yuan L, Zhou X, Duan J, Xiao H, Cai N, Han S, Ma X, Liu W, Chen CC, Wang L, Li X, Chen J, Kang N, Chen J, Shen Z, Malwal SR, Liu W, Shi Y, Oldfield E, Guo RT, Zhang Y. | 09/21/2019 |
| this paper describes regulation of human gammadelta T cells by BTN3A1 protein stability and ATP-binding cassette transporters | Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters.
Rhodes DA, Chen HC, Williamson JC, Hill A, Yuan J, Smith S, Rhodes H, Trowsdale J, Lehner PJ, Herrmann T, Eberl M., Free PMC Article | 06/29/2019 |
| Microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses. | MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1-IRF3 signaling axis.
Seo M, Lee SO, Kim JH, Hong Y, Kim S, Kim Y, Min DH, Kong YY, Shin J, Ahn K., Free PMC Article | 04/7/2018 |
| results show that ligand binding to BTN3A1 induces a conformational change within the intracellular domain that involves the JM region and is required for full activation. | The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region.
Nguyen K, Li J, Puthenveetil R, Lin X, Poe MM, Hsiao CC, Vinogradova O, Wiemer AJ., Free PMC Article | 11/26/2017 |
| findings show that changes in the juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or reduced gammadelta T cell reactivity | The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells.
Peigné CM, Léger A, Gesnel MC, Konczak F, Olive D, Bonneville M, Breathnach R, Scotet E. | 09/23/2017 |
| These findings support intracellular sensing of prenyl pyrophosphates by BTN3A1 rather than extracellular presentation. | Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells.
Wang H, Morita CT., Free PMC Article | 03/26/2016 |
| Human gamma-delta T cells are activated by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. | Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin.
Rhodes DA, Chen HC, Price AJ, Keeble AH, Davey MS, James LC, Eberl M, Trowsdale J., Free PMC Article | 04/25/2015 |
| evidence that gene(s) on Chr6 in addition to BTN3A1 are mandatory for PAg-mediated activation of Vgamma9Vdelta2 T cells. | Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6.
Riaño F, Karunakaran MM, Starick L, Li J, Scholz CJ, Kunzmann V, Olive D, Amslinger S, Herrmann T. | 11/22/2014 |
| Ligand binding to the BTN3A1 B30.2 domain affects residues in the juxtamembrane region, suggesting ligand-induced conformational change. | Synthesis of a phosphoantigen prodrug that potently activates Vγ9Vδ2 T-lymphocytes.
Hsiao CH, Lin X, Barney RJ, Shippy RR, Li J, Vinogradova O, Wiemer DF, Wiemer AJ. | 11/7/2014 |