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    TRIM31 tripartite motif containing 31 [ Homo sapiens (human) ]

    Gene ID: 11074, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer.

    An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer.
    Ding Y, Lu Y, Guo J, Chen S, Han X, Wang S, Zhang M, Wang R, Song J, Wang K, Qiu W, Qi W., Free PMC Article

    08/2/2024
    TRIM31 promotes the progression of oral squamous cell carcinoma through upregulating AKT phosphorylation and subsequent cellular glycolysis.

    TRIM31 promotes the progression of oral squamous cell carcinoma through upregulating AKT phosphorylation and subsequent cellular glycolysis.
    Sang SQ, Zhao YJ, Wang M, Zhong XQ, Yang ZC, Lu MM.

    08/3/2023
    Tripartite motif-containing protein 31 confers protection against nonalcoholic steatohepatitis by deactivating mitogen-activated protein kinase kinase kinase 7.

    Tripartite motif-containing protein 31 confers protection against nonalcoholic steatohepatitis by deactivating mitogen-activated protein kinase kinase kinase 7.
    Xu MX, Tan J, Ge CX, Dong W, Zhang LT, Zhu LC, Zhao JJ, Wang LY, Liu J, Wei H, Sun Y, Dai XL, Kuang Q, Li YL, Li H, Liu JY, Zou L, Liang RR, Zhang CF, Xu J, Wang BC.

    01/14/2023
    Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling.

    Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling.
    Yang Z, Xu B, Wu S, Yang W, Luo R, Geng S, Xin Z, Jin W, Shen X, Gu X, Zhang H, Wang H.

    10/8/2022
    CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis.

    CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis.
    Huang L, Huang L, Ming X, Wu J, Liu W, Xiao Y.

    10/1/2022
    Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers.

    Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers.
    Temena MA, Acar A., Free PMC Article

    08/20/2022
    Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

    Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.
    Guo Y, Li Q, Zhao G, Zhang J, Yuan H, Feng T, Ou D, Gu R, Li S, Li K, Lin P., Free PMC Article

    02/5/2022
    TRIM31 promotes apoptosis via TAK1-mediated activation of NF-kappaB signaling in sepsis-induced myocardial dysfunction.

    TRIM31 promotes apoptosis via TAK1-mediated activation of NF-κB signaling in sepsis-induced myocardial dysfunction.
    Yang X, Sun J, Sun F, Yao Y, Tian T, Zhou J, Shen W, Lu M, Lei M., Free PMC Article

    12/11/2021
    [Effect of TRIM31 Gene Silencing on the Proliferation and Apoptosis of U266 Cells and Its Mechanism].

    [Effect of TRIM31 Gene Silencing on the Proliferation and Apoptosis of U266 Cells and Its Mechanism].
    Long XX, Wen F, Chen Q, Cao YX, Huang XQ.

    07/3/2021
    TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3.

    TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3.
    Huang P, Liu W, Chen J, Hu Y, Wang Y, Sun J, Feng J.

    06/26/2021
    Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.

    Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.
    Ning L, Ko JM, Yu VZ, Ng HY, Chan CK, Tao L, Lam SY, Leong MM, Ngan RK, Kwong DL, Lee AW, Ng WT, Cheng A, Tung S, Lee VH, Lam KO, Kwan CK, Li WS, Yau S, Bei JX, Lung ML., Free PMC Article

    06/26/2021
    TRIM31 promotes acute myeloid leukemia progression and sensitivity to daunorubicin through the Wnt/beta-catenin signaling.

    TRIM31 promotes acute myeloid leukemia progression and sensitivity to daunorubicin through the Wnt/β-catenin signaling.
    Xiao Y, Deng T, Ming X, Xu J., Free PMC Article

    04/3/2021
    MicroRNA29c3p acts as a tumor suppressor gene and inhibits tumor progression in hepatocellular carcinoma by targeting TRIM31.

    MicroRNA‑29c‑3p acts as a tumor suppressor gene and inhibits tumor progression in hepatocellular carcinoma by targeting TRIM31.
    Lv T, Jiang L, Kong L, Yang J., Free PMC Article

    09/26/2020
    co-treatment with LPS and ATP increased the secretion of IL-1beta and expression of NLRP3 in human periodontal ligament fibroblasts, while TRIM31 overexpression could reverse these effects caused by LPS and ATP

    Tripartite motif 31 alleviates IL-1ß secretion via promoting the ubiquitination of pyrin domain domains-containing protein 3 in human periodontal ligament fibroblasts.
    Wu X, Lu M, Ding S, Zhong Q.

    05/30/2020
    TRIM31 upregulated the levels of nuclear p65 by promoting K63-linked polyubiquitination of tumor necrosis factor receptor-associated factor 2 (TRAF2) and sustained the activation of nuclear transcription factor kappa B (NF-kappaB) in pancreatic cancer cells.

    Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-κB signaling pathway.
    Yu C, Chen S, Guo Y, Sun C., Free PMC Article

    08/31/2019
    that TRIM31 promoted anoikis-resistance by targeting p53 for degradation and subsequently overactivating AMPK pathway

    Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.
    Guo P, Qiu Y, Ma X, Li T, Ma X, Zhu L, Lin Y, Han L.

    04/6/2019
    knockdown of TRIM31 reduced the expression of MMP2, MMP9 and phospho-Akt.

    Knockdown of TRIM31 suppresses proliferation and invasion of gallbladder cancer cells by down-regulating MMP2/9 through the PI3K/Akt signaling pathway.
    Li H, Zhang Y, Hai J, Wang J, Zhao B, Du L, Geng X.

    10/20/2018
    TRIM31 could promote hepatocellular carcinoma progression by targeting TSC1-TSC2 complex for degradation and further overactivating mTORC1 pathway.

    TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1-TSC2 complex.
    Guo P, Ma X, Zhao W, Huai W, Li T, Qiu Y, Zhang Y, Han L.

    10/13/2018
    feedback suppressor of NLRP3 inflammasome activity

    The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3.
    Song H, Liu B, Huai W, Yu Z, Wang W, Zhao J, Han L, Jiang G, Zhang L, Gao C, Zhao W., Free PMC Article

    09/22/2018
    Study reports that TRIM31 plays a critical role in the formation of autolysosomes in Atg5-/-or Atg7-/- cells, thus promoting elimination of invading bacteria through an Atg5- or Atg7-independent alternative pathway in the intestinal cells.

    TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells.
    Ra EA, Lee TA, Won Kim S, Park A, Choi HJ, Jang I, Kang S, Hee Cheon J, Cho JW, Eun Lee J, Lee S, Park B., Free PMC Article

    09/8/2018
    TRIM31 gene expression is regulated by miR-551b in ovarian cancer.

    Downregulation of Foxo3 and TRIM31 by miR-551b in side population promotes cell proliferation, invasion, and drug resistance of ovarian cancer.
    Wei Z, Liu Y, Wang Y, Zhang Y, Luo Q, Man X, Wei F, Yu X., Free PMC Article

    04/29/2017
    TRIM31 directly binds to NSE4, suggesting the existence of a TRIM31-MAGEA1-NSE4 complex reminiscent of the NSE1-NSE3-NSE4 trimer.

    The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex.
    Kozakova L, Vondrova L, Stejskal K, Charalabous P, Kolesar P, Lehmann AR, Uldrijan S, Sanderson CM, Zdrahal Z, Palecek JJ., Free PMC Article

    12/19/2015
    TRIM31 might serve as a tumor suppressor in non-small cell lung cancer.

    TRIM31 is downregulated in non-small cell lung cancer and serves as a potential tumor suppressor.
    Li H, Zhang Y, Zhang Y, Bai X, Peng Y, He P.

    08/23/2014
    The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system.

    The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system.
    Sugiura T.

    10/8/2011
    The TRIm31 gene is related to intelligence in an ADHD background.

    The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects.
    Rizzi TS, Arias-Vasquez A, Rommelse N, Kuntsi J, Anney R, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Ruano D, Van der Sluis S, Markunas CA, Garrett ME, Ashley-Koch AE, Kollins SH, Anastopoulos AD, Hansell NK, Wright MJ, Montgomery GW, Martin NG, Harris SE, Davies G, Tenesa A, Porteous DJ, Starr JM, Deary IJ, St Pourcain B, Davey Smith G, Timpson NJ, Evans DM, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Faraone SV, Franke B, Posthuma D., Free PMC Article

    05/21/2011
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