| Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum. | Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum.
Thurstin AA, Egeli AN, Goldsmith EC, Spinale FG, LaVoie HA., Free PMC Article | 02/4/2023 |
| Loss of TIMP4 (Tissue Inhibitor of Metalloproteinase 4) Promotes Atherosclerotic Plaque Deposition in the Abdominal Aorta Despite Suppressed Plasma Cholesterol Levels. | Loss of TIMP4 (Tissue Inhibitor of Metalloproteinase 4) Promotes Atherosclerotic Plaque Deposition in the Abdominal Aorta Despite Suppressed Plasma Cholesterol Levels.
Hu M, Jana S, Kilic T, Wang F, Shen M, Winkelaar G, Oudit GY, Rayner K, Zhang DW, Kassiri Z. | 08/14/2021 |
| The CRN2 increased the secretion of TIMP4 as well as the catalytic activity of MMP14. | CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
Solga R, Behrens J, Ziemann A, Riou A, Berwanger C, Becker L, Garrett L, de Angelis MH, Fischer L, Coras R, Barkovits K, Marcus K, Mahabir E, Eichinger L, Schröder R, Noegel AA, Clemen CS, German Mouse Clinic Consortium. | 04/4/2020 |
| High TIMP4 expression is associated with obesity, fatty liver and dyslipidemia. | Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption.
Sakamuri SSVP, Watts R, Takawale A, Wang X, Hernandez-Anzaldo S, Bahitham W, Fernandez-Patron C, Lehner R, Kassiri Z., Free PMC Article | 03/9/2019 |
| there are 7 CpG islands in the TIMP4 promoter which get methylated during the progression of heart failure which leads to its epigenetic silencing. | Epigenetic silencing of TIMP4 in heart failure.
Chaturvedi P, Tyagi SC., Free PMC Article | 07/1/2017 |
| High fat diet-induced obesity downregulates adipocyte MMP3 expression to trigger adipogenesis, and adipocyte TIMP4 may modulate this process to regulate hyperplastic vs. hypertrophic adipose tissue expansion, fat distribution, and metabolic health in a sex- and depot-dependent manner. | High-fat diet-induced obesity regulates MMP3 to modulate depot- and sex-dependent adipose expansion in C57BL/6J mice.
Wu Y, Lee MJ, Ido Y, Fried SK., Free PMC Article | 06/24/2017 |
| Our findings highlight a protective mechanism induced by PPARgamma in deoxycorticosterone acetate-salt treatment, establishing a novel mechanistic link between PPARgamma and TIMP-4. | Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension.
Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD., Free PMC Article | 04/16/2016 |
| TIMP4 augments contractility and induces differentiation of embryonic stem cells into cardiac phenotype. | Cardiac tissue inhibitor of matrix metalloprotease 4 dictates cardiomyocyte contractility and differentiation of embryonic stem cells into cardiomyocytes: Road to therapy.
Chaturvedi P, Kalani A, Familtseva A, Kamat PK, Metreveli N, Tyagi SC., Free PMC Article | 02/13/2016 |
| TIMP-4 might act as a negative regulator of adipogenesis through NFkB cascade modulation. | Tissue inhibitor of metalloproteases-4 (TIMP-4) modulates adipocyte differentiation in vitro.
Mejia-Cristobal LM, Reus E, Lizarraga F, Espinosa M, Ceballos-Cancino G, López TV, Garay S, Maldonado V, Melendez-Zajgla J. | 09/5/2015 |
| Replenishment of myocardial TIMP4 could serve as an effective therapy in post-I/R recovery for patients with reduced TIMP4. | Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4.
Takawale A, Fan D, Basu R, Shen M, Parajuli N, Wang W, Wang X, Oudit GY, Kassiri Z. | 10/4/2014 |
| TIMP-4 protein was localized to corpus luteum and theca-intera cells in various periods throughout the pregnancy and postpartum day 1. | [Changing trends of the expression of TIMP-4 in mouse ovary during pregnant and postpartum period].
Bu SM, Hu Z, Zhang F, Duan EK. | 12/22/2012 |
| Timp4(-/-) mice are more susceptible to MI but not to pressure overload, and TIMP4 functions in its capacity as a metalloproteinase inhibitor after myocardial infarction | Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.
Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, McKee TD, Kytö V, Saraste A, Jokinen E, Liu PP, Vuorio E, Khokha R., Free PMC Article | 09/27/2010 |
| This study suggests that tissue inhibitor of metalloproteinase-4 may restrict mouse blastocyst outgrowth and embryo implantation by inhibiting the activities of matrix metalloproteinases-2 and -9. | Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo.
Zhang J, Zhao YG, Cao YJ, Sang QX, Duan EK. | 01/21/2010 |
| Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene | Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene.
Young DA, Phillips BW, Lundy C, Nuttall RK, Hogan A, Schultz GA, Leco KJ, Clark IM, Edwards DR., Free PMC Article | 01/21/2010 |
| Contractile responses of normal LV rings were measured in the presence and absence of CIMP. CIMP shifted the pressure-length relationship to the left, attenuated LV dilatation, and had no effect on CaCl2-mediated contraction [CIMP] | Attenuation of oxidative stress and remodeling by cardiac inhibitor of metalloproteinase protein transfer.
Cox MJ, Hawkins UA, Hoit BD, Tyagi SC. | 01/21/2010 |
| molecular cloning and localization of the gene within intron 5 of the synapsin 2 gene | Characterization of the murine Timp4 gene, localization within intron 5 of the synapsin 2 gene and tissue distribution of the mRNA.
Rahkonen OP, Koskivirta IM, Oksjoki SM, Jokinen E, Vuorio EI. | 01/21/2010 |