| Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease. | Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease.
Stavrou MR, So SS, Finch AM, Ballouz S, Smith NJ. | 10/26/2023 |
| Ablation of Tas1r1 Reduces Lipid Accumulation Through Reducing the de Novo Lipid Synthesis and Improving Lipid Catabolism in Mice. | Ablation of Tas1r1 Reduces Lipid Accumulation Through Reducing the de Novo Lipid Synthesis and Improving Lipid Catabolism in Mice.
Ma L, Tian X, Xi F, He Y, Li D, Sun J, Yuan T, Li K, Fan L, Zhang C, Yang G, Yu T. | 08/27/2022 |
| Tas1r3 knockout leads to reduction in the size of pancreatic islets and their density in pancreatic tissue. | The Effect of the Taste Receptor Protein T1R3 on the Development of Islet Tissue of the Murine Pancreas.
Murovets VO, Sozontov EA, Zachepilo TG. | 08/10/2019 |
| RNAi-mediated depletion of Sp4 and Klf5 decreased Tas1r1 expression, while overexpression of Klf5, but not Sp4, significantly increased Tas1r1 expression in the myoblast cells. | Krüppel-like factor 5 (Klf5) regulates expression of mouse T1R1 amino acid receptor gene (Tas1r1) in C2C12 myoblast cells.
Hirata Y, Toyono T, Kokabu S, Obikane Y, Kataoka S, Nakatomi M, Masaki C, Hosokawa R, Seta Y. | 08/3/2019 |
| this study shows that taste receptor T1R1 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells | Taste receptor T1R1/T1R3 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells.
Liu S, Xu M, Zhu C, Zhao Q, Zhou F. | 05/25/2019 |
| residual sensitivity by the T1R1+T1R3 KO mice demonstrates that a T1R-independent mechanism can contribute to the detectability of high concentrations of this prototypical umami compound stimulus | Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.
Blonde GD, Travers SP, Spector AC., Free PMC Article | 01/5/2019 |
| T1R1/T1R3 modulates the mTOR pathway to regulate milk protein synthesis in the mouse mammary gland in vivo. | Milk protein synthesis is regulated by T1R1/T1R3, a G protein-coupled taste receptor, through the mTOR pathway in the mouse mammary gland.
Liu J, Wang Y, Li D, Wang Y, Li M, Chen C, Fang X, Chen H, Zhang C. | 07/28/2018 |
| siRNA silencing of T1R1 repressed beta-casein synthesis in HC11 cells both with and without essential amino acids present in the culture medium. T1R1/T1R3 serves as sensor of extracellular amino acids in mouse mammary epithelial cells and involved in milk protein synthesis regulation. | Amino acids regulate mTOR pathway and milk protein synthesis in a mouse mammary epithelial cell line is partly mediated by T1R1/T1R3.
Wang Y, Liu J, Wu H, Fang X, Chen H, Zhang C. | 07/14/2018 |
| T1R1/T1R3 have roles in regulating ERK1/2 and mTORC1 in MIN6 cells | Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells.
Wauson EM, Guerra ML, Dyachok J, McGlynn K, Giles J, Ross EM, Cobb MH., Free PMC Article | 05/14/2016 |
| Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice | Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice.
Yasumatsu K, Manabe T, Yoshida R, Iwatsuki K, Uneyama H, Takahashi I, Ninomiya Y., Free PMC Article | 12/5/2015 |
| This study demonstrated that that genetic transsynaptic tracing from bitter and umami receptor cells does not selectively label taste-specific neuronal circuits and reveal local taste receptor gene expression in the gustatory ganglia and the brain. | Transsynaptic Tracing from Taste Receptor Cells Reveals Local Taste Receptor Gene Expression in Gustatory Ganglia and Brain.
Voigt A, Bojahr J, Narukawa M, Hübner S, Boehm U, Meyerhof W., Free PMC Article | 09/26/2015 |
| A complex molecular mechanism involving changes in the properties of both the orthosteric and non-orthosteric sites of T1R1 underlies the determination of ligand specificity in mammalian T1R1/T1R3. | Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).
Toda Y, Nakagita T, Hayakawa T, Okada S, Narukawa M, Imai H, Ishimaru Y, Misaka T., Free PMC Article | 02/22/2014 |
| cell surface G protein coupled receptor (GPCR) TAS1R1-TAS1R3 (T1R1-T1R3) can sense extracellular amino acids, activate MTORC1, and inhibit autophagy | Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3.
Wauson EM, Zaganjor E, Cobb MH., Free PMC Article | 09/28/2013 |
| examined the function of umami taste receptor, which has a dimeric protein structure composed of Tas1r1 and Tas1r3, as an amino acid sensor | Umami taste receptor functions as an amino acid sensor via Gαs subunit in N1E-115 neuroblastoma cells.
Muroi Y, Ishii T. | 09/22/2012 |
| Data show that that Tas1r1 and Tas1r3 are expressed in murine and human spermatozoa. | Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.
Meyer D, Voigt A, Widmayer P, Borth H, Huebner S, Breit A, Marschall S, de Angelis MH, Boehm U, Meyerhof W, Gudermann T, Boekhoff I., Free PMC Article | 06/23/2012 |
| Data sugget that heterodimer of Tas1R1 and Tas1R3 is the fundamental receptor for the sensing amino acids and regulates the amino acid-induced insulin secretion in pancreatic beta-cells. | Amino acid taste receptor regulates insulin secretion in pancreatic β-cell line MIN6 cells.
Oya M, Suzuki H, Watanabe Y, Sato M, Tsuboi T. | 10/15/2011 |
| behavioral and physiological characterization of T1R1, T1R2, and T1R3 knockout mice | The receptors for mammalian sweet and umami taste.
Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS. | 01/21/2010 |
| T1R1 and T1R3 combine to function as a broadly tuned L-amino-acid sensor responding to most of the 20 standard amino acids, but not to their D-enantiomers or other compounds | An amino-acid taste receptor.
Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS. | 01/21/2010 |
| These results suggested that in fungiform papillae, gustducin might play a role in the sweet taste signal transduction cascade mediated by a sweet receptor based on the T1r2 and T1r3 combination, in fungiform papillae. | Regional expression patterns of taste receptors and gustducin in the mouse tongue.
Kim MR, Kusakabe Y, Miura H, Shindo Y, Ninomiya Y, Hino A. | 01/21/2010 |