| Study on the Mechanisms of Glralpha3 in Pain Sensitization of Endometriosis. | Study on the Mechanisms of Glrα3 in Pain Sensitization of Endometriosis.
Fan P, Liu R, Li Y, Wang S, Li T., Free PMC Article | 09/19/2024 |
| A phospho-deficient alpha3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons. | A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons.
Werynska K, Neumann E, Cramer T, Ganley RP, Gingras J, Zeilhofer HU. | 11/1/2023 |
| A Glra3 phosphodeficient mouse mutant establishes the critical role of protein kinase A-dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia. | A Glra3 phosphodeficient mouse mutant establishes the critical role of protein kinase A-dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia.
Werynska K, Gingras J, Benke D, Scheurer L, Neumann E, Zeilhofer HU., Free PMC Article | 09/18/2021 |
| This experiments identify the alpha3 subunit of the glycine receptor as a target of modulation in a mouse model of Rett syndrome. | Breathing disturbances in a model of Rett syndrome: A potential involvement of the glycine receptor α3 subunit?
Mesuret G, Dannenberg J, Arnoldt M, Grützner AA, Niebert M, Hülsmann S. | 10/13/2018 |
| alpha2 and alpha3 GlyRs are present in various regions of the forebrain and that alpha3 GlyRs specifically participate in tonic inhibition in the striatum and prefrontal cortex. | Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.
McCracken LM, Lowes DC, Salling MC, Carreau-Vollmer C, Odean NN, Blednov YA, Betz H, Harris RA, Harrison NL., Free PMC Article | 07/28/2018 |
| loss of alpha3-GlyRs in mice compromises suprathreshold auditory nerve activity, but not outer hair cell function | Loss of glycine receptors containing the α3 subunit compromises auditory nerve activity, but not outer hair cell function.
Dlugaiczyk J, Hecker D, Neubert C, Buerbank S, Campanelli D, Becker CM, Betz H, Knipper M, Rüttiger L, Schick B. | 01/20/2018 |
| GlyRalpha3 KO animals showed significantly impaired prepulse inhibition of the auditory startle response and changes in auditory brainstem response. | Deficit in acoustic signal-in-noise detection in glycine receptor α3 subunit knockout mice.
Tziridis K, Buerbank S, Eulenburg V, Dlugaiczyk J, Schulze H. | 12/23/2017 |
| Findings suggest that trigeminal primary afferent boutons receive presynaptic modulation via homomeric, extrasynaptic glycine receptor subunit alpha 3, and that different subtypes of glycine receptors may be involved in pre- and postsynaptic inhibition. | Expression of glycine receptor alpha 3 in the rat trigeminal neurons and central boutons in the brainstem.
Bae JY, Mah W, Rah JC, Park SK, Bae YC. | 10/14/2017 |
| presynaptic glycine release in the hypoglossal nucleus is partially depending on GlyR alpha3. | Presynaptic facilitation of glycinergic mIPSC is reduced in mice lacking α3 glycine receptor subunits.
Kono Y, Hülsmann S. | 12/17/2016 |
| The postsynaptic clusters of a3-containing GlyRs werelocated to efferent synapses of the medial and lateral olivocochlear bundle in the murine organ of Corti beyond the onset of hearing. | Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.
Buerbank S, Becker K, Becker CM, Brandt N, Engel J, Knipper M, Schick B, Dlugaiczyk J. | 05/19/2012 |
| Both GlyRalpha2 and GlyRalpha3 modulate local receptive fields in the retina: GlyRalpha3 mediates serial inhibition, whereas GlyRalpha2 participates in crossover inhibition. | Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.
Nobles RD, Zhang C, Müller U, Betz H, McCall MA., Free PMC Article | 04/28/2012 |
| these data suggest most glycine receptors and glycinergic synapses in the superficial dorsal horn contain alpha1 subunits and few are composed exclusively of alpha3 subunits. | Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse.
Graham BA, Tadros MA, Schofield PR, Callister RJ., Free PMC Article | 10/1/2011 |
| Data show that rhythmic respiratory activity is affected by phosphorylation status of the inhibitory glycine receptor alpha3 subtype, which controls glutamatergic and glycinergic neuronal discharges, subject to serotonergic receptor 1A modulation. | Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice.
Manzke T, Niebert M, Koch UR, Caley A, Vogelgesang S, Hülsmann S, Ponimaskin E, Müller U, Smart TG, Harvey RJ, Richter DW., Free PMC Article | 12/11/2010 |
| synapses containing GlyR alpha3 contribute in large part to synaptic inhibition in lamina II; results clearly show that presynaptic GABA/glycine release properties are influenced by the nature and complexity of postsynaptic inhibitory receptor subtypes | Plasticity of synaptic inhibition in mouse spinal cord lamina II neurons during early postnatal development and after inactivation of the glycine receptor alpha3 subunit gene.
Rajalu M, Müller UC, Caley A, Harvey RJ, Poisbeau P. | 04/12/2010 |
| Glycinergic sIPSCs of amacrine cells displayed medium fast kinetics (mean decay time constant tau=11+/-2 ms), which were completely absent in the Glra3-/- mouse. | Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice.
Weiss J, O'Sullivan GA, Heinze L, Chen HX, Betz H, Wässle H. | 01/21/2010 |
| Spinal glycine receptor alpha3 subunit does not contribute to pain after peripheral nerve injury or formalin injection. | Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection.
Hösl K, Reinold H, Harvey RJ, Müller U, Narumiya S, Zeilhofer HU. | 01/21/2010 |
| demonstrated that inhibition of GlyR alpha3 by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization; GlyR alpha3 is distinctly expressed in superficial layers of the spinal cord dorsal horn | GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.
Harvey RJ, Depner UB, Wässle H, Ahmadi S, Heindl C, Reinold H, Smart TG, Harvey K, Schütz B, Abo-Salem OM, Zimmer A, Poisbeau P, Welzl H, Wolfer DP, Betz H, Zeilhofer HU, Müller U. | 01/21/2010 |