| A neurodevelopmental disorder associated with a loss-of-function missense mutation in RAB35. | A neurodevelopmental disorder associated with a loss-of-function missense mutation in RAB35.
Aguila A, Salah S, Kulasekaran G, Shweiki M, Shaul-Lotan N, Mor-Shaked H, Daana M, Harel T, McPherson PS., Free PMC Article | 05/21/2024 |
| This reference shows that the oxidoreductase MICAL1 is an effector of Rab35 during cytokinesis. | Oxidation of F-actin controls the terminal steps of cytokinesis.
Frémont S, Hammich H, Bai J, Wioland H, Klinkert K, Rocancourt M, Kikuti C, Stroebel D, Romet-Lemonne G, Pylypenko O, Houdusse A, Echard A., Free PMC Article | 02/28/2024 |
| This reference shows that MiniBAR/GARRE1 is a dual Rab35 and Rac1 effector during ciliogenesis. | MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis.
Serres MP, Shaughnessy R, Escot S, Hammich H, Cuvelier F, Salles A, Rocancourt M, Verdon Q, Gaffuri AL, Sourigues Y, Malherbe G, Velikovsky L, Chardon F, Sassoon N, Tinevez JY, Callebaut I, Formstecher E, Houdusse A, David NB, Pylypenko O, Echard A. | 02/28/2024 |
| DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy. | DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy.
Kumar R, Francis V, Ioannou MS, Aguila A, Khan M, Banks E, Kulasekaran G, McPherson PS. | 08/3/2023 |
| Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours. | Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours.
Li C, Gao Z, Cui Z, Liu Z, Bian Y, Sun H, Wang N, He Z, Li B, Li F, Li Z, Wang L, Zhang D, Yang L, Xu Z, Xu H. | 03/21/2023 |
| BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance. | BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.
Lin H, Tang M, Ji C, Girardi P, Cvetojevic G, Chen D, Koren SA, Johnson GVW., Free PMC Article | 06/25/2022 |
| Transcellular propagation of fibrillar alpha-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent. | Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent.
Rodrigues PV, de Godoy JVP, Bosque BP, Amorim Neto DP, Tostes K, Palameta S, Garcia-Rosa S, Tonoli CCC, de Carvalho HF, de Castro Fonseca M., Free PMC Article | 05/7/2022 |
| Rab35 regulates insulin secretion via phogrin in pancreatic beta cells. | Rab35 regulates insulin secretion via phogrin in pancreatic β cells.
Lu C, Zhao Q, Wang D, Feng Y, Feng L, Li Z, Shi Q. | 04/2/2022 |
| Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population. | Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.
Wang HL, Yeh TH, Huang YZ, Weng YH, Chen RS, Lu CS, Wei KC, Liu YC, Chen YL, Chen CL, Chen YJ, Lin YW, Hsu CC, Chiu CH, Chiu CC. | 01/29/2022 |
| MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells. | MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells.
Wen H, Liu Z, Tang J, Bu L., Free PMC Article | 01/15/2022 |
| Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission. | Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission.
Iannantuono NVG, Emery G. | 09/4/2021 |
| An Arf/Rab cascade controls the growth and invasiveness of glioblastoma. | An Arf/Rab cascade controls the growth and invasiveness of glioblastoma.
Kulasekaran G, Chaineau M, Piscopo VEC, Verginelli F, Fotouhi M, Girard M, Tang Y, Dali R, Lo R, Stifani S, McPherson PS., Free PMC Article | 09/4/2021 |
| The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia. | The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.
Villagomez FR, Medina-Contreras O, Cerna-Cortes JF, Patino-Lopez G., Free PMC Article | 07/17/2021 |
| Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth. | Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth.
Sawade L, Grandi F, Mignanelli M, Patiño-López G, Klinkert K, Langa-Vives F, Di Guardo R, Echard A, Bolino A, Haucke V., Free PMC Article | 08/22/2020 |
| analysis of structural basis for effector recognition in Rab35/ACAP2 and Rab35/RUSC2 complexes | Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.
Lin L, Shi Y, Wang M, Wang C, Zhu J, Zhang R. | 06/13/2020 |
| Study finds that RAB35 expression and localization are regulated by HOTAIR in hepatocellular carcinoma cells. | Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma.
Yang L, Peng X, Li Y, Zhang X, Ma Y, Wu C, Fan Q, Wei S, Li H, Liu J., Free PMC Article | 08/24/2019 |
| A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration. | A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.
Corallino S, Malinverno C, Neumann B, Tischer C, Palamidessi A, Frittoli E, Panagiotakopoulou M, Disanza A, Malet-Engra G, Nastaly P, Galli C, Luise C, Bertalot G, Pece S, Di Fiore PP, Gauthier N, Ferrari A, Maiuri P, Scita G., Free PMC Article | 12/22/2018 |
| The authors propose that Rab35-GTP is a critical regulator of autophagy through recruiting autophagy receptor NDP52. | Rab35 GTPase recruits NDP52 to autophagy targets.
Minowa-Nozawa A, Nozawa T, Okamoto-Furuta K, Kohda H, Nakagawa I., Free PMC Article | 09/30/2017 |
| The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion. | MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells.
Deng W, Wang Y, Gu L, Duan B, Cui J, Zhang Y, Chen Y, Sun S, Dong J, Du J., Free PMC Article | 09/30/2017 |
| The involvement of Rab35 in diverse and apparently unrelated cellular functions can be explained by the central role of this GTPase in regulating phosphoinositides and F-actin, both on endosomes and at the plasma membrane[review]. | Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond.
Klinkert K, Echard A. | 09/16/2017 |
| Data suggest that Rab35, interacting with TBC1D10A, functions in vascular endothelial cells as a negative regulator of histamine-evoked, Ca2+-dependent Weibel-Palade body exocytosis, most likely acting through the downstream effectors ACAP2 and Arf6. (Rab35 = rab GTP-binding protein 53; TBC1D10A = TBC1 domain family member 10A; ACAP2 = centaurin beta2; Arf6 = ADP-ribosylation factor 6) | Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies.
Biesemann A, Gorontzi A, Barr F, Gerke V., Free PMC Article | 08/5/2017 |
| Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35. | EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.
Duan B, Cui J, Sun S, Zheng J, Zhang Y, Ye B, Chen Y, Deng W, Du J, Zhu Y, Chen Y, Gu L. | 07/29/2017 |
| Here the authors report that EspG interacts specifically with the small GTPases ARF6 and Rab35 during infection. | Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection.
Furniss RC, Slater S, Frankel G, Clements A., Free PMC Article | 06/24/2017 |
| Authors propose that the precise spatial and temporal activation of Rab35 acts as a major switch for OCRL recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking. | Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.
Cauvin C, Rosendale M, Gupta-Rossi N, Rocancourt M, Larraufie P, Salomon R, Perrais D, Echard A. | 11/5/2016 |
| Rab35 serves as a clathrin-mediated endocytosis detector. Loss of Rab35 input leads to elevated Arf6-GTP and shifts the sorting of clathrin-independent endocytosis cargo proteins to lysosomes. | Sorting of Clathrin-Independent Cargo Proteins Depends on Rab35 Delivered by Clathrin-Mediated Endocytosis.
Dutta D, Donaldson JG., Free PMC Article | 06/28/2016 |