| miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway. | miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway.
Ding Y, Wang Z, Chen C, Li D, Wang W, Jia Y, Qin Y. | 02/16/2024 |
| KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy. | KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy.
Wang Y, Liao H, Wang Y, Zhou J, Wang F, Xie Y, Zhao K, Gao W., Free PMC Article | 01/8/2022 |
| KLK11 acts as a tumor-inhibitor in laryngeal squamous cell carcinoma through the inactivation of Akt/Wnt/beta-catenin signaling. | KLK11 acts as a tumor-inhibitor in laryngeal squamous cell carcinoma through the inactivation of Akt/Wnt/β-catenin signaling.
Zhao R, Wang S, Liu J, Xu C, Zhang S, Shao Y, Duan X. | 12/25/2021 |
| Kallikrein 11 Down-regulation in Breast Carcinoma: Correlation With Prognostic Parameters. | Kallikrein 11 Down-regulation in Breast Carcinoma: Correlation With Prognostic Parameters.
Ozturk T, Kain EZ, Tuzuner MB, Diren A, Batur S, Yilmaz-Aydogan H, Ozturk O, Isbir T., Free PMC Article | 10/30/2021 |
| Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis. | Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
Siriphak S, Chanakankun R, Proungvitaya T, Roytrakul S, Tummanatsakun D, Seubwai W, Wongwattanakul M, Proungvitaya S., Free PMC Article | 07/17/2021 |
| Diagnostic and prognostic values of KLK11 in nasopharyngeal carcinoma. | Diagnostic and prognostic values of KLK11 in nasopharyngeal carcinoma.
Li XL, Bi HL, Yuan TJ, Huang YY. | 05/8/2021 |
| The functional role of glycosylation in prostate-specific KLK11 could pave the way to a deeper understanding of their biology and to medical applications. | Activation and activity of glycosylated KLKs 3, 4 and 11.
Guo S, Briza P, Magdolen V, Brandstetter H, Goettig P. | 05/18/2019 |
| novel KLK11 and KLK12 splice variants represent new potential cancer biomarkers | Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology.
Adamopoulos PG, Kontos CK, Scorilas A. | 05/18/2019 |
| Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases | Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.
Geng X, Liu Y, Diersch S, Kotzsch M, Grill S, Weichert W, Kiechle M, Magdolen V, Dorn J., Free PMC Article | 12/9/2017 |
| Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer | Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer.
Kolin DL, Sy K, Rotondo F, Bassily MN, Kovacs K, Brezden-Masley C, Streutker CJ, Yousef GM. | 02/18/2017 |
| KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma | KLK11 mRNA expression predicts poor disease-free and overall survival in colorectal adenocarcinoma patients.
Alexopoulou DK, Kontos CK, Christodoulou S, Papadopoulos IN, Scorilas A. | 08/29/2015 |
| hK11 expression in gastric cancer appears to be associated with a better prognosis. hK11 may be a prognostic biomarker of gastric cancer. | Is human kallikrein-11 in gastric cancer treated with surgery and adjuvant chemoradiotherapy associated with survival?
Unal D, Tasdemir A, Oguz A, Eroglu C, Cihan YB, Turak EE, Karaman H, Soyuer S. | 08/9/2014 |
| The aim of this study was to monitor serum levels of two microRNAs (miR-21 and miR-141) and three kallikreins (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy. | Circulating microRNAs and kallikreins before and after radical prostatectomy: are they really prostate cancer markers?
Egidi MG, Cochetti G, Serva MR, Guelfi G, Zampini D, Mechelli L, Mearini E., Free PMC Article | 06/14/2014 |
| Our data showed that UVB-induced TSLP might increase secretion of the T-helper type 2-attracting chemokine (c-c motif) ligand 17 by human dendritic cells. | UVB induces HIF-1α-dependent TSLP expression via the JNK and ERK pathways.
Jang Y, Jeong SH, Park YH, Bae HC, Lee H, Ryu WI, Park GH, Son SW. | 12/28/2013 |
| HOXB8 and KLK11 may be classified as valuable biomarkers, as they can predict the effects of FOLFOX4 chemotherapy in primary advanced colorectal cancer patients | Identification of HOXB8 and KLK11 expression levels as potential biomarkers to predict the effects of FOLFOX4 chemotherapy.
Li S, Lu X, Chi P, Pan J. | 11/2/2013 |
| Human airway trypsin-like protease can stimulate mucin5AC hypersecretion through a PAR2-mediated signaling pathway in 16HBE cells. | Human airway trypsin-like protease induces mucin5AC hypersecretion via a protease-activated receptor 2-mediated pathway in human airway epithelial cells.
Liu C, Li Q, Zhou X, Kolosov VP, Perelman JM. | 08/31/2013 |
| Patients harboring KLK11-positive tumors had a significantly decreased risk of death. | Diagnostic and prognostic significance of human kallikrein 11 (KLK11) mRNA expression levels in patients with laryngeal cancer.
Patsis C, Yiotakis I, Scorilas A. | 09/15/2012 |
| Low KLK11 protein expression is associated with gastric cancer. | Identification and validation of Kallikrein-ralated peptidase 11 as a novel prognostic marker of gastric cancer based on immunohistochemistry.
Wen YG, Wang Q, Zhou CZ, Yan DW, Qiu GQ, Yang C, Tang HM, Peng ZH. | 11/5/2011 |
| For the first time, we report lower expression of KLK11 in CaP compared to BPH and slight upregulation of KLK11 in advanced tumors compared to localized ones | Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients.
Jamaspishvili T, Scorilas A, Kral M, Khomeriki I, Kurfurstova D, Kolar Z, Bouchal J. | 09/10/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.
Klein RJ, Halldén C, Cronin AM, Ploner A, Wiklund F, Bjartell AS, Stattin P, Xu J, Scardino PT, Offit K, Vickers AJ, Grönberg H, Lilja H., Free PMC Article | 06/30/2010 |
| the up-regulation of TMPRSS2 and the down-regulation of KLK11 in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness as well as novel prognostic indicators for prostate cancer. | Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer.
Bi X, He H, Ye Y, Dai Q, Han Z, Liang Y, Zhong W. | 06/14/2010 |
| hK11 may be another prognostic biomarker of low rectal carcinoma. Strong positive hK11 staining associated with various clinicopathologic features. Patients with weak hK11 positive expression showed better survival rates. | Over-expression of human kallikrein 11 is associated with poor prognosis in patients with low rectal carcinoma.
Yu X, Tang HY, Li XR, He XW, Xiang KM. | 06/14/2010 |
| Data show that it was unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers. | The kallikrein family of proteins as urinary biomarkers for the detection of prostate cancer.
Sardana G, Diamandis EP. | 01/25/2010 |
| synergistic effects between estrogens and androgens on estrogen-sensitive genes may have implications on the role of the kallikreins 10, 11, and 14 in associated risk of breast cancer and progression. | Androgens act synergistically to enhance estrogen-induced upregulation of human tissue kallikreins 10, 11, and 14 in breast cancer cells via a membrane bound androgen receptor.
Paliouras M, Diamandis EP., Free PMC Article | 01/21/2010 |
| Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11. | Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11.
Thomadaki H, Mavridis K, Talieri M, Scorilas A. | 01/21/2010 |