| Combined therapy of CAR-IL-15/IL-15Ralpha-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer. | Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer.
Ye J, Liu Q, He Y, Song Z, Lin B, Hu Z, Hu J, Ning Y, Cai C, Li Y., Free PMC Article | 02/21/2024 |
| GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway. | GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway.
Tiu YC, Gong L, Zhang Y, Luo J, Yang Y, Tang Y, Lee WM, Guan XY. | 11/19/2022 |
| Glioma pathogenesis-related protein 1 performs dual functions in tumor cells. | Glioma pathogenesis-related protein 1 performs dual functions in tumor cells.
Wang J, Li Z, Yin F, Zhang R, Zhang Y, Wang Z, Sheng X. | 05/14/2022 |
| GLIPR1 and SPARC expression profile reveals a signature associated with prostate Cancer Brain metastasis. | GLIPR1 and SPARC expression profile reveals a signature associated with prostate Cancer Brain metastasis.
Oliveira-Barros EG, Branco LC, Da Costa NM, Nicolau-Neto P, Palmero C, Pontes B, Ferreira do Amaral R, Alves-Leon SV, Marcondes de Souza J, Romão L, Fernandes PV, Martins I, Takiya CM, Ribeiro Pinto LF, Palumbo A Jr, Nasciutti LE. | 12/4/2021 |
| Study demonstrates that GLIPR1 expression is frequently reduced in the plasma cells of multiple myeloma (MM)patients. Functional results in MM cell lines and in vivo suggest that GLIPR1 is unlikely to be a potent tumor suppressor in MM. | GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice.
Friend N, Noll JE, Opperman KS, Clark KC, Mrozik KM, Vandyke K, Hewett DR, Zannettino ACW., Free PMC Article | 04/25/2020 |
| Data found that GLIPR1 expression level was low in human bladder cancer tissues. Also, GLIPR1 was shown to inhibit the expression of TPX2. | TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.
Yan L, Li Q, Yang J, Qiao B. | 10/20/2018 |
| High GLIPR1 expression is associated with cisplatin resistance in lung cancer. | GLIPR1 modulates the response of cisplatin-resistant human lung cancer cells to cisplatin.
Gong X, Liu J, Zhang D, Yang D, Min Z, Wen X, Wang G, Li H, Song Y, Bai C, Li J, Zhou J., Free PMC Article | 10/7/2017 |
| The present study identified GLIPR1 and miR-16 as key components for regulating the proliferation, migration, invasion and cancer-initiating cells in osteosarcoma | GLIPR1 inhibits the proliferation and induces the differentiation of cancer-initiating cells by regulating miR-16 in osteosarcoma.
Dong J, Bi B, Zhang L, Gao K. | 03/18/2017 |
| This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth. | GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer.
Sheng X, Bowen N, Wang Z., Free PMC Article | 10/1/2016 |
| Overexpression of RTVP-1 in human neural stem cells induced mesenchymal differentiation, whereas silencing of RTVP-1 in glioma stem cells (GSCs) decreased the mesenchymal transformation and stemness of these cells. | RTVP-1 promotes mesenchymal transformation of glioma via a STAT-3/IL-6-dependent positive feedback loop.
Giladi ND, Ziv-Av A, Lee HK, Finniss S, Cazacu S, Xiang C, Waldman Ben-Asher H, deCarvalho A, Mikkelsen T, Poisson L, Brodie C., Free PMC Article | 08/6/2016 |
| RTVP-1 regulates glioma cell spreading, migration and invasion and that these effects are mediated via interaction with N-WASP and by interfering with the inhibitory effect of hnRNPK on the function of this protein. | RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK.
Ziv-Av A, Giladi ND, Lee HK, Cazacu S, Finniss S, Xiang C, Pauker MH, Barda-Saad M, Poisson L, Brodie C., Free PMC Article | 05/28/2016 |
| Data indicate that combining adenoviral vector-mediated GLIPR1 gene therap (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors. | Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models.
Fujita T, Satoh T, Timme TL, Hirayama T, Zhu JX, Kusaka N, Naruishi K, Yang G, Goltsov A, Wang J, Vlachaki MT, Teh BS, Brian Butler E, Thompson TC., Free PMC Article | 09/27/2014 |
| Based on the observed overexpression in AML samples, GliPR1 should be further explored as a potential target for AML | Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.
Capalbo G, Mueller-Kuller T, Koschmieder S, Klein HU, Ottmann OG, Hoelzer D, Scheuring UJ. | 04/12/2014 |
| miR-137 inhibits Glioblastom stem cell self-renewal and promotes their differentiation by targeting RTVP-1 which down-regulates CXCR4. | MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1.
Bier A, Giladi N, Kronfeld N, Lee HK, Cazacu S, Finniss S, Xiang C, Poisson L, deCarvalho AC, Slavin S, Jacoby E, Yalon M, Toren A, Mikkelsen T, Brodie C., Free PMC Article | 02/8/2014 |
| GLIPR1 interacts with Hsc70, and GLIPR1 overexpression or Hsc70 knockdown leads to transcriptional suppression of AURKA and TPX2. | Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.
Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, Hawke D, Kim SM, Lee JS, Goltsov AA, Park S, Ittmann MM, Troncoso P, Thompson TC., Free PMC Article | 12/28/2013 |
| GLIPR1 core structure has a conserved central cavity via which CAP proteins are likely to bind to shared ligands. | Structural studies of human glioma pathogenesis-related protein 1.
Asojo OA, Koski RA, Bonafé N., Free PMC Article | 04/7/2012 |
| Data show that the expression of GLIPR1 and c-Myc were inversely correlated in prostate cancer. | GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction.
Li L, Ren C, Yang G, Fattah EA, Goltsov AA, Kim SM, Lee JS, Park S, Demayo FJ, Ittmann MM, Troncoso P, Thompson TC., Free PMC Article | 03/10/2012 |
| RTVP-1 plays a role in the effect of serum response factor on glioma cell migration | RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration.
Ziv-Av A, Taller D, Attia M, Xiang C, Lee HK, Cazacu S, Finniss S, Kazimirsky G, Sarid R, Brodie C. | 01/14/2012 |
| demonstrate that GLIPR1 is a methylation-silenced gene in the acute myeloid leukemia patients | Identification of GLIPR1 tumor suppressor as methylation-silenced gene in acute myeloid leukemia by microarray analysis.
Xiao YH, Li XH, Tan T, Liang T, Yi H, Li MY, Zeng GQ, Wan XX, Qu JQ, He QY, Li JH, Chen Y, Xiao ZQ. | 12/17/2011 |
| GLIPR1 expression is downregulated or even lost by promoter methylation in acute myeloid leukemia. | [Methylation and expression of glioma pathogenesis-related protein 1 gene in acute myeloid leukemia].
Liang T, Tan T, Xiao Y, Yi H, Li C, Peng F, Chen Z, Xiao Z. | 05/7/2011 |
| X-ray data have been collected to beyond 1.9 A resolution from a crystal of GLIPR1 that belonged to the orthorhombic space group P2(1)2(1)2 with average unit-cell parameters a = 85.1, b = 79.5, c = 38.9 A and either a monomer or dimer | Expression, purification, crystallization and preliminary X-ray analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1.
Bonafé N, Zhan B, Bottazzi ME, Perez OA, Koski RA, Asojo OA., Free PMC Article | 03/26/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Induction of GliPR expression by HIV-1 was confirmed in P4-CCR5 cells. | Inhibition of HIV-1 replication by small interfering RNAs directed against glioma pathogenesis related protein (GliPR) expression.
Capalbo G, Müller-Kuller T, Dietrich U, Hoelzer D, Ottmann OG, Scheuring UJ., Free PMC Article | 05/31/2010 |
| GLIPR1 is a proapoptotic tumor suppressor acting through the ROS-JNK pathway. | Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling.
Li L, Abdel Fattah E, Cao G, Ren C, Yang G, Goltsov AA, Chinault AC, Cai WW, Timme TL, Thompson TC. | 01/21/2010 |