| DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. | DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma.
Bai Q, Liu R, Quan C, Han X, Wang D, Wang C, Wang Z, Li L, Li L, Piao H, Song Y, Yan G., Free PMC Article | 02/7/2024 |
| miR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEK. | miR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEK.
Song Y, Wang Z, Jiang J, Piao Y, Bai Q, Piao Q, Li L, Xu C, Liu H, Piao H, Li L, Yan G. | 10/29/2022 |
| Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle Attenuates Collagen-Induced Arthritis. | Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle Attenuates Collagen-Induced Arthritis.
Cao J, Su J, An M, Yang Y, Zhang Y, Zuo J, Zhang N, Zhao Y. | 10/9/2021 |
| Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis. | Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Chen Z, Huo D, Li L, Liu Z, Li Z, Xu S, Huang Y, Wu W, Zhou C, Liu Y, Kuang M, Wu F, Li H, Qian P, Song G, Wu X, Chen J, Hou Y., Free PMC Article | 10/9/2021 |
| Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit. | Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit.
Yue L, Wan R, Luan S, Zeng W, Cheung TH. | 01/2/2021 |
| Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. | Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
Capitano ML, Mor-Vaknin N, Saha AK, Cooper S, Legendre M, Guo H, Contreras-Galindo R, Kappes F, Sartor MA, Lee CT, Huang X, Markovitz DM, Broxmeyer HE., Free PMC Article | 04/18/2020 |
| These findings define DEK as an important and multifunctional mediator of homologous recombination. | DEK is required for homologous recombination repair of DNA breaks.
Smith EA, Gole B, Willis NA, Soria R, Starnes LM, Krumpelbeck EF, Jegga AG, Ali AM, Guo H, Meetei AR, Andreassen PR, Kappes F, Vinnedge LM, Daniel JA, Scully R, Wiesmüller L, Wells SI., Free PMC Article | 11/17/2018 |
| DEK is crucial to the development of arthritis in mouse models, thus making it an appropriate target for aptamer-based therapy. | DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis.
Mor-Vaknin N, Saha A, Legendre M, Carmona-Rivera C, Amin MA, Rabquer BJ, Gonzales-Hernandez MJ, Jorns J, Mohan S, Yalavarthi S, Pai DA, Angevine K, Almburg SJ, Knight JS, Adams BS, Koch AE, Fox DA, Engelke DR, Kaplan MJ, Markovitz DM., Free PMC Article | 11/10/2018 |
| DEK was expressed throughout the brain in both sexes, including the medial prefrontal cortex (prelimbic, infralimbic and dorsal peduncular). DEK was also abundant in all amygdalar subdivisions (basolateral, central and medial) and in the hippocampus including the CA1, CA2, CA3, dentate gyrus (DG), ventral subiculum and entorhinal cortex. | Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice.
Ghisays V, Nguyen ET, Streicher J, Pease NA, Fitzgerald M, Estrada CM, Franco-Villanueva A, Privette Vinnedge L, Solomon MB., Free PMC Article | 11/10/2018 |
| Dek contributes to esophageal squamous cell carcinoma tumorigenesis at least partially through keratinocyte intrinsic pathways which promote cellular and tumor growth. | Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.
Matrka MC, Cimperman KA, Haas SR, Guasch G, Ehrman LA, Waclaw RR, Komurov K, Lane A, Wikenheiser-Brokamp KA, Wells SI., Free PMC Article | 07/14/2018 |
| Data suggests that DEK participates in the process of embryo implantation and might play a role in influencing stromal cell decidualization through mediating cell proliferation, apoptosis and DNA damage. | Roles of DEK in the endometrium of mice in early pregnancy.
Yang Y, Wu M, Geng Y, Liu X, Yang Y, Chen X, Ding Y, He J, Wang Y, Xie L. | 12/23/2017 |
| DEK expression during normal hematopoiesis did reveal a relationship with specific cell types implicating a distinct function during myeloid differentiation | DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML).
Logan GE, Mor-Vaknin N, Braunschweig T, Jost E, Schmidt PV, Markovitz DM, Mills KI, Kappes F, Percy MJ. | 08/1/2015 |
| Studies demonstrate that DEK overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt/beta-catenin signaling. | The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.
Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, Adams AK, Cancelas JA, Waltz SE, Wells SI., Free PMC Article | 07/25/2015 |
| Results highlight a novel function of DEK as a guardian of chromatin by restricting widespread histone access, and in particular by modulating differential H3.3 loading in specific chromatin areas. | The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity.
Ivanauskiene K, Delbarre E, McGhie JD, Küntziger T, Wong LH, Collas P., Free PMC Article | 06/20/2015 |
| data demonstrate that DEK stimulates HNSCC cellular growth and identify DeltaNp63 as a novel DEK effector | DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.
Adams AK, Hallenbeck GE, Casper KA, Patil YJ, Wilson KM, Kimple RJ, Lambert PF, Witte DP, Xiao W, Gillison ML, Wikenheiser-Brokamp KA, Wise-Draper TM, Wells SI., Free PMC Article | 04/11/2015 |
| DEK has potent effects on HSCs, HPCs, and hematopoiesis, information of biological and potential clinical interest. | DEK regulates hematopoietic stem engraftment and progenitor cell proliferation.
Broxmeyer HE, Kappes F, Mor-Vaknin N, Legendre M, Kinzfogl J, Cooper S, Hangoc G, Markovitz DM., Free PMC Article | 10/6/2012 |
| The hallmark of translocation in acutte myeloid leukemiaa is the expression of the DEK/CAN fusion protein. | The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation.
Oancea C, Rüster B, Henschler R, Puccetti E, Ruthardt M. | 01/1/2011 |
| Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo. | Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.
Wise-Draper TM, Mintz-Cole RA, Morris TA, Simpson DS, Wikenheiser-Brokamp KA, Currier MA, Cripe TP, Grosveld GC, Wells SI., Free PMC Article | 01/21/2010 |
| Our conclusion is that DEK could serve as an architectural protein at the promoter or enhancer sites of a subfraction of human genes. | The distribution of the DEK protein in mammalian chromatin.
Hu HG, Scholten I, Gruss C, Knippers R. | 01/21/2010 |
| DEK is a neuroblastoma tumor antigen. | Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen.
Zheng J, Kohler ME, Chen Q, Weber J, Khan J, Johnson BD, Orentas RJ., Free PMC Article | 01/21/2010 |