| The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10. | The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10.
Yang X, Li S, Wu Y, Ge F, Chen Y, Xiong Q., Free PMC Article | 12/19/2020 |
| The AD-associated protein TMED10 negatively regulates autophagy by inhibiting ATG4B activity. | Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation.
Shin JH, Park SJ, Jo DS, Park NY, Kim JB, Bae JE, Jo YK, Hwang JJ, Lee JA, Jo DG, Kim JC, Jung YK, Koh JY, Cho DH., Free PMC Article | 07/11/2020 |
| Study validated EXT1, TM9SF2, and TMED10 as important host factors for vaccinia virus infection. In addition, TMED10 was found to be crucial for virus-induced plasma membrane blebbing and phosphatidylserine-induced micropinocytosis. | A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.
Luteijn RD, van Diemen F, Blomen VA, Boer IGJ, Manikam Sadasivam S, van Kuppevelt TH, Drexler I, Brummelkamp TR, Lebbink RJ, Wiertz EJ., Free PMC Article | 06/27/2020 |
| Results indicate that transmembrane trafficking protein Tmp21(TMP21) could regulate autophagy by modulating reactive oxygen species (ROS) production and TOR serine-threonine kinases (mTOR) activation. | TMP21 regulates autophagy by modulating ROS production and mTOR activation.
Shin JH, Cho DH. | 06/6/2020 |
| TMP21 is genetically associated with Alzheimer's disease, with the novel Tmp21 SNP as a risk factor for Alzheimer's pathogenesis. | A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis.
Zhang X, Wu Y, Cai F, Liu S, Bromley-Brits K, Xia K, Song W. | 05/25/2019 |
| Low TMED10 expression is associated with breast cancer. | TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.
Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N, Itoh F, Nakano Y, Iemura SI, van Dinther M, Natsume T, Ten Dijke P, Itoh S., Free PMC Article | 07/29/2017 |
| Surface plasmon resonance and solution NMR analyses revealed that p24beta1 and p24delta1 GOLD domains interact weakly (Kd= ~10(-4)M). | 3D Structure and Interaction of p24β and p24δ Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport.
Nagae M, Hirata T, Morita-Matsumoto K, Theiler R, Fujita M, Kinoshita T, Yamaguchi Y. | 06/24/2017 |
| TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy, which may be associated with activation of AMPK/mTOR pathway. | TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy through activation of the AMPK/mTOR pathway.
Xu X, Gao H, Qin J, He L, Liu W., Free PMC Article | 10/1/2016 |
| Study demonstrates that NleF binds to the human Tmp21 protein and subsequently disrupts intracellular protein trafficking. | The enterohemorrhagic Escherichia coli effector protein NleF binds mammalian Tmp21.
Olsen RL, Echtenkamp F, Cheranova D, Deng W, Finlay BB, Hardwidge PR., Free PMC Article | 12/14/2013 |
| This study suggested that The role ofTMP21 in the modulation of gamma-secretase activity and protein trafficking and related to alzheimer disease. | The role of TMP21 in trafficking and amyloid-β precursor protein (APP) processing in Alzheimer's disease.
Bromley-Brits K, Song W. | 09/8/2012 |
| Data show that the level of p23 expression is critical for neuronal function, and p23 overexpression initiates a cascade in brainstem that leads to severe motor deficits and other neurological problems, culminating in premature death. | Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice.
Gong P, Roseman J, Fernandez CG, Vetrivel KS, Bindokas VP, Zitzow LA, Kar S, Parent AT, Thinakaran G., Free PMC Article | 04/28/2012 |
| Results suggest that Tmp21 is a novel protein that preferentially binds to Beta(2)-microglobulin-free MHC-I heavy chains. | Tmp21, a novel MHC-I interacting protein, preferentially binds to Β2-microglobulin-free MHC-I heavy chains.
Jun Y, Ahn K. | 10/22/2011 |
| p23 acts as an anchoring protein that retains PKCdelta at the perinuclear region, thus limiting the availability of this kinase for activation in response to stimuli. | p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function.
Wang H, Xiao L, Kazanietz MG., Free PMC Article | 07/2/2011 |
| Transmembrane protein 23 and p24A differentially control G-protein coupled receptor trafficking and signaling in astrocytes. | Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.
Luo W, Wang Y, Reiser G. | 05/21/2011 |
| These results demonstrate that p23/Tmp21 acts as an anchor that distinctively modulates compartmentalization of C1 domain-containing proteins, and it plays an essential role in beta2-chimaerin relocalization. | p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains.
Wang H, Kazanietz MG., Free PMC Article | 09/20/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF., Free PMC Article | 09/15/2010 |
| the TMP21 transmembrane domain promotes its association with the presenilin complex that results in decreased gamma-cleavage activity | TMP21 transmembrane domain regulates gamma-secretase cleavage.
Pardossi-Piquard R, Böhm C, Chen F, Kanemoto S, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE., Free PMC Article | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB, Hammond N, Stolk L, Nica A, Inouye M, Hofman A, Stephens J, Wheeler E, Arp P, Gwilliam R, Jhamai PM, Potter S, Chaney A, Ghori MJ, Ravindrarajah R, Ermakov S, Estrada K, Pols HA, Williams FM, McArdle WL, van Meurs JB, Loos RJ, Dermitzakis ET, Ahmadi KR, Hart DJ, Ouwehand WH, Wareham NJ, Barroso I, Sandhu MS, Strachan DP, Livshits G, Spector TD, Uitterlinden AG, Deloukas P., Free PMC Article | 08/12/2009 |
| p23 is widely distributed throughout the frontal cortex, hippocampus and cerebellum of control and Alzheimer disease (AD)brains; steady-state p23 levels are reduced in the brains of individuals with AD. | Localization and regional distribution of p23/TMP21 in the brain.
Vetrivel KS, Kodam A, Gong P, Chen Y, Parent AT, Kar S, Thinakaran G., Free PMC Article | 01/21/2010 |
| Taken together, these results indicate that the degradation of TMP21, as with the other presenilin-associated gamma-secretase complex members, is mediated by the ubiquitin-proteasome pathway. | TMP21 degradation is mediated by the ubiquitin-proteasome pathway.
Liu S, Bromley-Brits K, Xia K, Mittelholtz J, Wang R, Song W. | 01/21/2010 |
| TMP21 behaves as a regulator of gamma- but not epsilon-cleavages of beta-amyloid precursor protein generated by presenilin-dependent gamma-secretase complex. | TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin.
Dolcini V, Dunys J, Sevalle J, Chen F, Guillot-Sestier MV, St George-Hyslop P, Fraser PE, Checler F. | 01/21/2010 |
| TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity | TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P. | 01/21/2010 |