| AMPK Attenuation of beta-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of beta-Arrestin-1-ser330. | AMPK Attenuation of β-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of β-Arrestin-1-ser330.
Zhao M, Cao N, Gu H, Xu J, Xu W, Zhang D, Wei TW, Wang K, Guo R, Cui H, Wang X, Guo X, Li Z, He K, Li Z, Zhang Y, Shyy JY, Dong E, Xiao H. | 10/8/2024 |
| Macrophage beta-arrestin-1 deteriorates DSS-induced colitis through interaction with NF-kappaB signaling. | Macrophage β-arrestin-1 deteriorates DSS-induced colitis through interaction with NF-κB signaling.
Ke P, Zhu DN, Liu MZ, Yan H, Zhao QJ, Du J, Wei W, Chen XW, Liu C. | 03/25/2024 |
| Role of Formyl Peptide Receptors and beta-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with alphaVbeta3-Integrin. | Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin.
Kim EY, Dryer SE., Free PMC Article | 02/9/2024 |
| ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2alpha to inhibit ER stress signaling. | ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling.
Luo Y, Lei Y, Zhou H, Chen Y, Liu H, Jiang J, Xu C, Wu B., Free PMC Article | 02/5/2024 |
| Depletion of beta-arrestin-1 in macrophages enhances atherosclerosis in ApoE[-/-] mice. | Depletion of β-arrestin-1 in macrophages enhances atherosclerosis in ApoE(-/-) mice.
Shao BZ, Liu MZ, Zhu DN, Yan H, Ke P, Wei W, Han T, Liu C. | 11/27/2023 |
| beta-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium. | β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.
Hua F, Zhu H, Yu W, Zheng Q, Zhang L, Liang W, Lin Y, Xiao F, Yi P, Xiong Y, Dong Y, Li H, Fang L, Liu H, Ying J, Wang X., Free PMC Article | 05/18/2023 |
| Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and beta-arrestin-1 Pathways. | Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and β-arrestin-1 Pathways.
Ni Z, Wang Y, Shi C, Zhang X, Gong H, Dong Y. | 12/10/2022 |
| ARRB2 (beta-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation. | ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.
Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD., Free PMC Article | 12/3/2022 |
| HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G1/S cycle. | HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G(1)/S cycle.
Lei Y, Xu X, Liu H, Chen L, Zhou H, Jiang J, Yang Y, Wu B., Free PMC Article | 07/16/2022 |
| beta-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy. | β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy.
Woo JA, Yan Y, Kee TR, Cazzaro S, McGill Percy KC, Wang X, Liu T, Liggett SB, Kang DE., Free PMC Article | 04/2/2022 |
| The Two beta-Arrestins Regulate Distinct Metabolic Processes: Studies with Novel Mutant Mouse Models. | The Two β-Arrestins Regulate Distinct Metabolic Processes: Studies with Novel Mutant Mouse Models.
Wess J., Free PMC Article | 01/29/2022 |
| beta-Arrestin-dependent ERK signaling reduces anxiety-like and conditioned fear-related behaviors in mice. | β-Arrestin-dependent ERK signaling reduces anxiety-like and conditioned fear-related behaviors in mice.
Ko MJ, Chiang T, Mukadam AA, Mulia GE, Gutridge AM, Lin A, Chester JA, van Rijn RM., Free PMC Article | 01/22/2022 |
| Activation of PTH1R alleviates epididymitis and orchitis through Gq and beta-arrestin-1 pathways. | Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways.
Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM, Lin HC, Yu X, Sun JP., Free PMC Article | 12/18/2021 |
| LSD-stimulated behaviors in mice require beta-arrestin 2 but not beta-arrestin 1. | LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1.
Rodriguiz RM, Nadkarni V, Means CR, Pogorelov VM, Chiu YT, Roth BL, Wetsel WC., Free PMC Article | 11/13/2021 |
| CXCR7 ameliorates myocardial infarction as a beta-arrestin-biased receptor. | CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor.
Ishizuka M, Harada M, Nomura S, Ko T, Ikeda Y, Guo J, Bujo S, Yanagisawa-Murakami H, Satoh M, Yamada S, Kumagai H, Motozawa Y, Hara H, Fujiwara T, Sato T, Takeda N, Takeda N, Otsu K, Morita H, Toko H, Komuro I., Free PMC Article | 11/13/2021 |
| ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation. | ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation.
Zhang Z, Xu X, Tian W, Jiang R, Lu Y, Sun Q, Fu R, He Q, Wang J, Liu Y, Yu H, Sun B. | 10/9/2021 |
| betaarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1. | βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.
Nieto A, Hara MR, Quereda V, Grant W, Saunders V, Xiao K, McDonald PH, Duckett DR., Free PMC Article | 07/3/2021 |
| beta-Arrestin-1 is required for adaptive beta-cell mass expansion during obesity. | β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity.
Barella LF, Rossi M, Pydi SP, Meister J, Jain S, Cui Y, Gavrilova O, Fulgenzi G, Tessarollo L, Wess J., Free PMC Article | 06/19/2021 |
| ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes. | ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes.
Xu X, Zhang Z, Lu Y, Sun Q, Liu Y, Liu Q, Tian W, Yin Y, Yu H, Sun B., Free PMC Article | 05/15/2021 |
| Biological Role of Arrestin-1 Oligomerization. | Biological Role of Arrestin-1 Oligomerization.
Samaranayake S, Vishnivetskiy SA, Shores CR, Thibeault KC, Kook S, Chen J, Burns ME, Gurevich EV, Gurevich VV., Free PMC Article | 02/6/2021 |
| Barr1 can directly interact with Epac2; sulfonylureas such as glibenclamide promote Barr1/Epac2 complex formation, triggering enhanced Rap1 signaling and insulin secretion | β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion.
Barella LF, Rossi M, Zhu L, Cui Y, Mei FC, Cheng X, Chen W, Gurevich VV, Wess J., Free PMC Article | 06/27/2020 |
| betaarr1 plays a role in radiation-induced intestinal injury. Intestinal betaarr1 was highly expressed in radiation enteritis and in a radiation model. betaarr1 knockout (KO) or knockdown mice exhibited increased proliferation in intestinal Lgr5+ stem cell, crypt reproduction, and survival following radiation. betaarr1 knockdown with siRNA enhanced intestinal Lgr5(+) stem cell proliferation after radiation via targetin... | β-Arrestin1-mediated decrease in endoplasmic reticulum stress impairs intestinal stem cell proliferation following radiation.
Liu Z, Jiang J, He Q, Liu Z, Yang Z, Xu J, Huang Z, Wu B. | 06/6/2020 |
| results for the first time demonstrate that melatonin safeguards against nonalcoholic fatty liver disease by eliminating ASK1 activation via inhibiting TRAFs-mediated ASK1 deubiquitination and stabilization in a beta-arrestin-1 dependent manner. | Melatonin safeguards against fatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination and stabilization in a β-arrestin-1 dependent manner.
Li DJ, Tong J, Li YH, Meng HB, Ji QX, Zhang GY, Zhu JH, Zhang WJ, Zeng FY, Huang G, Hua X, Shen FM, Wang P. | 03/14/2020 |
| Using skeletal muscle (SKM)-specific knockout (KO) mouse lines, study showed that the loss of SKM Barr2, but not of SKM Barr1, resulted in mild improvements in glucose tolerance in diet-induced obese mice. Data indicate that SKM beta-arrestins play only rather subtle roles (SKM Barr2) in regulating whole-body glucose homeostasis and SKM insulin sensitivity. | Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice.
Meister J, Bone DBJ, Godlewski G, Liu Z, Lee RJ, Vishnivetskiy SA, Gurevich VV, Springer D, Kunos G, Wess J., Free PMC Article | 02/15/2020 |
| results demonstrate a novel role for ARRB1 in VEGFR regulation and suggest a mechanism for cross talk between G protein-coupled receptors and VEGFRs in pulmonary arterial hypertension. | Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1.
Ma Z, Yu YR, Badea CT, Kovacs JJ, Xiong X, Comhair S, Piantadosi CA, Rajagopal S., Free PMC Article | 01/4/2020 |