| The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients. | The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients.
Bose C, Kshirsagar S, Vijayan M, Kumar S, Singh SP, Hindle A, Reddy PH. | 01/5/2024 |
| Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease. | Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease.
Baig J, Sawant N, Rawat P, Reddy AP, Reddy PH, Kshirsagar S. | 11/16/2023 |
| Crucial Role of RLIP76 in Promoting Glycolysis and Tumorigenesis by Stabilization of HIF-1alpha in Glioma Cells Under Hypoxia. | Crucial Role of RLIP76 in Promoting Glycolysis and Tumorigenesis by Stabilization of HIF-1α in Glioma Cells Under Hypoxia.
Wang Q, Zhang C, Zhu J, Zhang L, Chen H, Qian J, Luo C. | 10/15/2022 |
| The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review. | The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.
Boughrara W, Chentouf A. | 07/30/2022 |
| RLIP depletion induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells. | RLIP depletion induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells.
Singhal SS, Mohanty A, Kulkarni P, Horne D, Awasthi S, Salgia R., Free PMC Article | 10/2/2021 |
| Activating p53 function by targeting RLIP. | Activating p53 function by targeting RLIP.
Singhal SS, Horne D, Singhal J, Awasthi S, Salgia R., Free PMC Article | 07/24/2021 |
| Prevention of mammary carcinogenesis in MMTV-neu mice by targeting RLIP. | Prevention of mammary carcinogenesis in MMTV-neu mice by targeting RLIP.
Singhal J, Kulkarni P, Horne D, Awasthi S, Salgia R, Singhal SS., Free PMC Article | 04/13/2021 |
| Results indicated that the expression levels of RLIP76 were significantly upregulated in IDH1Wt gliomas compared with the IDH1Mut gliomas. | Increased RLIP76 expression in IDH1 wild‑type glioblastoma multiforme is associated with worse prognosis.
Wang Q, Zhang L, Cui Y, Zhang C, Chen H, Gu J, Qian J, Luo C., Free PMC Article | 06/6/2020 |
| Studies indicate the glutathione-conjugates (GS-Es) transport activity of ralA binding protein 1 (RLIP), which determines the rate of ligand endocytosis [Review]. | RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis.
Singhal SS, Salgia R, Verma N, Horne D, Awasthi S. | 02/22/2020 |
| RLBP1 may mediate squamous cell tumorigenesis in oral cavity, independently of the RAS protein and through Akt. | RALBP1 regulates oral cancer cells via Akt and is a novel target of miR-148a-3p and miR-148b-3p.
Ieong C, Ma J, Lai W. | 01/18/2020 |
| 2HF has potential to be combined with RLIP inhibition/depletion to more effectively suppress primary breast tumor growth and metastasis to the lungs. | RLIP inhibition suppresses breast-to-lung metastasis.
Singhal J, Chikara S, Horne D, Salgia R, Awasthi S, Singhal SS., Free PMC Article | 12/14/2019 |
| this review provides strong evidence for the role of RLIP as an effector protein which catalyzes the efflux of GS-E, a process which is a crucial component of diverse cellular signaling pathways including mitosis, proliferation, differentiation, apoptosis, and endocytosis in breast cancer | RLIP: An existential requirement for breast carcinogenesis.
Singhal SS, Salgia R, Singhal S, Horne D, Awasthi S. | 08/24/2019 |
| RLIP76 plays a critical role in cellular proliferation, apoptosis, cell cycle distribution, cell movement and invasion in melanoma | RLIP76 silencing inhibits cell proliferation and invasion in melanoma cell line A375.
Liu N, Du CH. | 07/7/2018 |
| In the exons and exon-intron boundaries of ABCB5 and RLIP76 genes. | Pharmacogenetics of ABCB5, ABCC5 and RLIP76 and doxorubicin pharmacokinetics in Asian breast cancer patients.
Lal S, Sutiman N, Ooi LL, Wong ZW, Wong NS, Ang PCS, Chowbay B. | 04/21/2018 |
| the miR143-3p level was markedly lower in participants with ovarian cancer compared with normal control, while the expression of RALBP1 mRNA and protein were evidently overexpressed in participants with ovarian cancer compared with normal control. | Dysregulation of micro-143-3p and BALBP1 contributes to the pathogenesis of the development of ovarian carcinoma.
Zhang H, Li W. | 03/18/2017 |
| RLIP76 knockdown increased autophagic flux and apoptosis in U251 glioma cells. | RLIP76 Depletion Enhances Autophagic Flux in U251 Cells.
Zhang C, Cai Z, Liang Q, Wang Q, Lu Y, Hu L, Hu G. | 03/18/2017 |
| Phosphorylation level of Akt declined from 138.45+/-13.8 to 69.9+/-29.7% in SGC-7901, and from 115.5+/-26.6 to 49.07+/-27% in MGC-803 and phosphorylation level of mTOR also significantly decreased.While apoptosis of gastric cancer(GA) cells increased which we verified with apoptosis proteins and staining analysis. Our data showed that RLIP76 plays a significant oncogenic role in GC and it maybe a potential target in GC | RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer.
Wang W, Liu J, Qi J, Zhang J, Zhu Q, Qin C., Free PMC Article | 03/11/2017 |
| report showed that RLIP76 expression was significantly increased in breast cancer samples and positively correlated with the malignant status of breast cancer patients; results indicated that high RLIP76 expression was associated with poor prognosis of breast cancer patients | RLIP76 expression as a prognostic marker of breast cancer.
Wang CZ, Yuan P, Xu B, Yuan L, Yang HZ, Liu X. | 09/3/2016 |
| RLIP76 expression is induced by TNF-alpha and follows the induction kinetics of inflammation markers, suggesting that inflammation can influence RLIP76 expression at the blood brain barrier. | Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells.
Bennani-Baiti B, Toegel S, Viernstein H, Urban E, Noe CR, Bennani-Baiti IM., Free PMC Article | 06/4/2016 |
| RLIP76 downregulation in HT29 CRC cells suppressed cell growth, enhanced cell apoptosis, induced cell cycle arrest, and inhibited cell invasion by decreasing MMP2 expression. | RLIP76 blockade by siRNA inhibits proliferation, enhances apoptosis, and suppresses invasion in HT29 colon cancer cells.
Zhang Y, Song X, Gong W, Zhu Z, Liu X, Hou Q, Sun Y, Chai J, Zou L, Guan J. | 04/23/2016 |
| High RLIP76 expression is associated with a poor outcome of meningioma. | Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence.
Fan SY, Jiang JD, Qian J, Lu YC, Hu GH, Luo C, Hou WD, Wang Q., Free PMC Article | 02/13/2016 |
| results revealed that the effect of miR-101 on prostate cancer cell apoptosis was due to RLIP76 regulation of the PI3K/Akt/Bcl-2 signaling pathway | RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer.
Yang J, Song Q, Cai Y, Wang P, Wang M, Zhang D. | 11/7/2015 |
| RalBP1 protein is an independent predictor of poor survival and early relapse for CRC patients | Overexpression of RalBP1 in colorectal cancer is an independent predictor of poor survival and early tumor relapse.
Mollberg NM, Steinert G, Aigner M, Hamm A, Lin FJ, Elbers H, Reissfelder C, Weitz J, Buchler MW, Koch M., Free PMC Article | 05/23/2015 |
| RLIP76 is a potential target for developing novel therapeutic strategies for leukemia | Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells.
Yao K, Xing H, Yang W, Liao A, Wu B, Li Y, Zhang R, Liu Z. | 01/17/2015 |
| RLIP76 is a node for Rho and Ras family signalling. [Review] | Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling.
Mott HR, Owen D. | 09/6/2014 |