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    FGL2 fibrinogen like 2 [ Homo sapiens (human) ]

    Gene ID: 10875, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CD8[+] T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcgammaRIIB.

    CD8(+) T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcγRIIB.
    Bennion KB, Liu D, Dawood AS, Wyatt MM, Alexander KL, Abdel-Hakeem MS, Paulos CM, Ford ML., Free PMC Article

    07/9/2024
    Presence and activity of Fibrinogen like protein 2 in platelets.

    Presence and activity of Fibrinogen like protein 2 in platelets.
    Cherny I, Hasin P, Philosoph LK, Shahal-Zimra Y, Gurion R, Rabizadeh E., Free PMC Article

    05/23/2023
    A homozygous truncating mutation of FGL2 is associated with immune dysregulation.

    A homozygous truncating mutation of FGL2 is associated with immune dysregulation.
    Janssen E, Alosaimi MF, Alazami AM, Alsuliman A, Alaiya A, Al-Saud B, Al-Mousa H, Al-Zaid TJ, Smith E, Platt CD, Alruwaili H, Albanyan S, Al-Mayouf SM, Geha RS.

    02/11/2023
    Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis.

    Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis.
    Denicolò S, Nair V, Leierer J, Rudnicki M, Kretzler M, Mayer G, Ju W, Perco P., Free PMC Article

    02/11/2023
    Fibrinogen-like protein 2 in gastrointestinal stromal tumour.

    Fibrinogen-like protein 2 in gastrointestinal stromal tumour.
    Pulkka OP, Viisanen L, Tynninen O, Laaksonen M, Reichardt P, Reichardt A, Eriksson M, Hall KS, Wardelmann E, Nilsson B, Sihto H, Joensuu H., Free PMC Article

    04/9/2022
    Soluble fibrinogenlike protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.

    Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.
    You Y, Huang S, Liu H, Fan C, Liu K, Wang Z., Free PMC Article

    11/6/2021
    Predictive value of soluble fibrinogen-like protein 2 for survival in traumatic patients with sepsis.

    Predictive value of soluble fibrinogen-like protein 2 for survival in traumatic patients with sepsis.
    Yang Y, Chen J, Yang J, Yi C, Yang F, Gao W, Li Z, Bai X.

    08/14/2021
    Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.

    Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.
    Hou XX, Wang XQ, Zhou WJ, Li DJ., Free PMC Article

    08/7/2021
    Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production.

    Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5(n-3 DPA) production.
    Lei J, Zhou Y, Zhao H, Chen Y, Yan G, Wu L, Xu Y, Zhang J, Zhang X, Wang J, Li D, Li Y., Free PMC Article

    07/31/2021
    Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions.

    Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions.
    Zeng M, Zeng K.

    07/17/2021
    Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population.

    Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population.
    Kim HR, Jung SH, Kim J, Jang H, Kang SH, Hwangbo S, Kim JP, Kim SY, Kim B, Kim S, Jeong JH, Yoon SJ, Park KW, Kim EJ, Yoon B, Jang JW, Hong JY, Choi SH, Noh Y, Kim KW, Kim SE, Lee JS, Jung NY, Lee J, Kim BC, Son SJ, Hong CH, Na DL, Seo SW, Won HH, Kim HJ., Free PMC Article

    07/3/2021
    Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder.

    Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder.
    Hu J, Wang H, Li X, Liu Y, Mi Y, Kong H, Xi D, Yan W, Luo X, Ning Q, Wang X., Free PMC Article

    05/29/2021
    Identification of integrative molecular and clinical profiles of Fibrinogen-like protein 2 in gliomas using 1323 samples.

    Identification of integrative molecular and clinical profiles of Fibrinogen-like protein 2 in gliomas using 1323 samples.
    Song Z, Wang Y, Du Y, Zhang Z, Yuan Y.

    05/29/2021
    Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma.

    Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma.
    Yuan X, Li Y, Zhang AZ, Jiang CH, Li FP, Xie YF, Li JF, Liang WH, Zhang HJ, Liu CX, Pang LJ, Shen XH, Li F, Hu JM., Free PMC Article

    05/22/2021
    Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer.

    Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer.
    Feng Y, Guo C, Wang H, Zhao L, Wang W, Wang T, Feng Y, Yuan K, Huang G., Free PMC Article

    05/1/2021
    Soluble Fibrinogen-like protein 2 plays a role in varicocele induced male infertility.

    Soluble Fibrinogen-like protein 2 plays a role in varicocele induced male infertility.
    Elesawy FM, Abdel Hafeez NA, Abdelsalam OH, Akl EM.

    04/3/2021
    Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2.

    Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2.
    Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, Guo B, Zhang Q, Cao Y, Liu T, Cui L, Xu W., Free PMC Article

    11/21/2020
    The FGL2 prothrombinase contributes to the pathological process of experimental pulmonary hypertension.

    The FGL2 prothrombinase contributes to the pathological process of experimental pulmonary hypertension.
    Fan C, Wang J, Mao C, Li W, Liu K, Wang Z.

    10/24/2020
    Data show that RvDp5 enhances fibrinogen-like protein 2 (Fgl2) secretion via ADAM metallopeptidase domain 17 (ADAM17) and synergistically accelerates resolution of inflammation.

    Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5.
    Zhou Y, Lei J, Xie Q, Wu L, Jin S, Guo B, Wang X, Yan G, Zhang Q, Zhao H, Zhang J, Zhang X, Wang J, Gu J, Liu X, Ye D, Miao H, Serhan CN, Li Y., Free PMC Article

    05/9/2020
    High FGL2 expression is associated with glioma.

    The Role of Fibrinogen-Like Protein 2 on Immunosuppression and Malignant Progression in Glioma.
    Latha K, Yan J, Yang Y, Gressot LV, Kong LY, Manyam G, Ezhilarasan R, Wang Q, Sulman EP, Eric Davis R, Huang S, Fuller GN, Rao A, Heimberger AB, Li S, Rao G., Free PMC Article

    03/14/2020
    Elevation of serum sFGL2 concentrations is strongly associated with the acute pancreatitis severity and has the potential to distinguish delirium after acute pancreatitis.

    Serum soluble fibrinogen-like protein 2 concentration predicts delirium after acute pancreatitis.
    Xu WB, Hu QH, Wu CN, Fan ZK, Song ZF., Free PMC Article

    12/7/2019
    The increase in intrahepatic and plasma sFGL2 by Tregs may restrict AIH progression by inhibiting conventional CD8+ T cells and Tc17 cell function. The high correlation between sFGL2 and disease severity may predict AIH outcome.

    Soluble Fgl2 restricts autoimmune hepatitis progression via suppressing Tc17 and conventional CD8+ T cell function.
    Ai G, Yan W, Yu H, Xiao F, Xi D, Ma K, Huang J, Luo X, Wan X, Ning Q.

    10/5/2019
    The presence of infectious/autoimmune diseases does not significantly alter FGL2 activity in the peripheral blood

    [THE EFFECT OF INFECTIOUS AND AUTOIMMUNE DISEASES ON PROCOAGULANT ACTIVITY OF FIBRINOGEN-LIKE PROTEIN 2 IN THE PERIPHERAL BLOOD].
    Cherny I, Shepshelovich D, Lahav M, Rabizadeh E.

    08/24/2019
    FGL2 expression is a novel, independent, and an adverse prognostic factor of clinical outcomes in patients with clear cell renal cell carcinoma.

    Increased expression of Fibrinogen-Like Protein 2 is associated with poor prognosis in patients with clear cell renal cell carcinoma.
    Tang M, Cao X, Li P, Zhang K, Li Y, Zheng QY, Li GQ, Chen J, Xu GL, Zhang KQ., Free PMC Article

    07/6/2019
    Serum FGL2 is a promising biomarker for assessing the severity and prognosis in severe TBI

    The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury.
    Chen TJ, Ji MX, Tao ZQ, Fu QY, Xiong K, Cheng B.

    03/23/2019
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