| Rac1 activation and expression of alpha2-chimaerin are stimulated by single-trial contextual fear conditioning. The balance between activated Rac1 and expressed alpha2-chimaerin defines dynamic long-term memory maintenance. | Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory.
Lv L, Liu Y, Xie J, Wu Y, Zhao J, Li Q, Zhong Y., Free PMC Article | 03/7/2020 |
| These findings reveal a role for ephrin bidirectional signaling upstream of mutant alpha2-chimaerin in Duane retraction syndrome, which may contribute to the selective vulnerability of abducens motor neurons in this disorder | Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome.
Nugent AA, Park JG, Wei Y, Tenney AP, Gilette NM, DeLisle MM, Chan WM, Cheng L, Engle EC., Free PMC Article | 09/16/2017 |
| This study showed that, in the mouse, hippocampal alpha2-chimaerin acts in the late postnatal stages (juvenile and adolescence) to establish both the baseline level of the dendritic spine morphology and normal contextual fear-learning ability in adulthood | Developmental RacGAP α2-Chimaerin Signaling Is a Determinant of the Morphological Features of Dendritic Spines in Adulthood.
Iwata R, Matsukawa H, Yasuda K, Mizuno H, Itohara S, Iwasato T., Free PMC Article | 01/16/2016 |
| Developmental alpha2-chimaerin activity is important for adult cognition. | RacGAP α2-chimaerin function in development adjusts cognitive ability in adulthood.
Iwata R, Ohi K, Kobayashi Y, Masuda A, Iwama M, Yasuda Y, Yamamori H, Tanaka M, Hashimoto R, Itohara S, Iwasato T. | 05/30/2015 |
| Chimaerins are RhoGTPase-activating proteins that are EphA4 effectors and have been implicated in a number of processes including growth cone collapse, axon guidance, dendritic spine development and the formation of corticospinal motor circuits. | Identification of α-chimaerin as a candidate gene for critical period neuronal plasticity in cat and mouse visual cortex.
Yang CB, Zheng YT, Kiser PJ, Mower GD., Free PMC Article | 03/24/2012 |
| These findings establish a new alpha2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders. | α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2.
Ip JP, Shi L, Chen Y, Itoh Y, Fu WY, Betz A, Yung WH, Gotoh Y, Fu AK, Ip NY. | 02/18/2012 |
| These findings identify alpha2-chimaerin as an indispensable effector for EphA4 in cortical and spinal motor circuits. | alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.
Beg AA, Sommer JE, Martin JH, Scheiffele P. | 01/21/2010 |
| Our results reveal an alpha-chimaerin-dependent signaling pathway downstream of EphA4, which is essential for axon guidance decisions and neuronal circuit formation in vivo. | EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin.
Wegmeyer H, Egea J, Rabe N, Gezelius H, Filosa A, Enjin A, Varoqueaux F, Deininger K, Schnütgen F, Brose N, Klein R, Kullander K, Betz A. | 01/21/2010 |
| Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of Efnb3 forward signaling | Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling.
Iwasato T, Katoh H, Nishimaru H, Ishikawa Y, Inoue H, Saito YM, Ando R, Iwama M, Takahashi R, Negishi M, Itohara S. | 01/21/2010 |
| lpha1-chimaerin is an activity-regulated Rho GTPase regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors | The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology.
Buttery P, Beg AA, Chih B, Broder A, Mason CA, Scheiffele P., Free PMC Article | 01/21/2010 |
| Chimaerin, one of the Rho GTPase activating proteins, is transcriptionally up-regulated after exposure to neurotrophins in post-natal cerebellar neurons. | Chimaerins act downstream from neurotrophins in overcoming the inhibition of neurite outgrowth produced by myelin-associated glycoprotein.
Mizuno T, Yamashita T, Tohyama M. | 01/21/2010 |