| FRS2 regulated by miR-429 and miR-206 promotes angiogenesis in osteosarcoma. | FRS2 regulated by miR-429 and miR-206 promotes angiogenesis in osteosarcoma.
Zhu Y, Liu Z, Cao L, Fan G, Ji R, Zhang L, Daji S, Zhu H, Wang Y, Zhou G. | 02/9/2024 |
| Over-expression of microRNA-145 Elevating Autophagy Activities via Downregulating FRS2 Expression. | Over-expression of microRNA-145 Elevating Autophagy Activities via Downregulating FRS2 Expression.
Tian K, Deng B, Han X, Zheng H, Lin T, Wang Z, Zhang Y, Wang G. | 01/17/2024 |
| Expression of fibroblast growth factor receptor substrate 2 (FRS2) in primary retroperitoneal liposarcoma and its clinical implications. | Expression of fibroblast growth factor receptor substrate 2 (FRS2) in primary retroperitoneal liposarcoma and its clinical implications.
Chen WD, Miao CL. | 07/20/2023 |
| Hsa_circ_0093741 competes with FRS2 for miR-562 binding sites to promote nephroblastoma progression. | Hsa_circ_0093741 competes with FRS2 for miR-562 binding sites to promote nephroblastoma progression.
Yong J, He J, Ning F. | 05/4/2023 |
| Expression of FRS2 in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: an immunohistochemical analysis of 182 cases with genetic data. | Expression of FRS2 in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: an immunohistochemical analysis of 182 cases with genetic data.
Jing W, Lan T, Qiu Y, Peng R, Lu Y, Chen H, Chen M, He X, Chen C, Zhang H., Free PMC Article | 02/26/2022 |
| Circular RNA circUBR4 regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells through miR-185-5p/FRS2 axis. | Circular RNA circUBR4 regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells through miR-185-5p/FRS2 axis.
Sun C, Li J, Li Y, Li L, Huang G. | 02/5/2022 |
| Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) regulates fibroblast growth factor receptor substrate 2 (FRS2) by targeting microRNA (miR)-29-3p in hypertrophic scar fibroblasts. | Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) regulates fibroblast growth factor receptor substrate 2 (FRS2) by targeting microRNA (miR)-29-3p in hypertrophic scar fibroblasts.
Wu Q, Chen J, Tan Z, Wang D, Zhou J, Li D, Cen Y., Free PMC Article | 12/11/2021 |
| Upregulation of lncRNA ZFAS1 promotes lung adenocarcinoma progression by sponging miR-1271-5p and upregulating FRS2. | Upregulation of lncRNA ZFAS1 promotes lung adenocarcinoma progression by sponging miR-1271-5p and upregulating FRS2.
Fan G, Jiao J, Shen F, Chu F., Free PMC Article | 08/14/2021 |
| LncRNA ANRIL regulates cell proliferation and migration via sponging miR-339-5p and regulating FRS2 expression in atherosclerosis. | LncRNA ANRIL regulates cell proliferation and migration via sponging miR-339-5p and regulating FRS2 expression in atherosclerosis.
Huang T, Zhao HY, Zhang XB, Gao XL, Peng WP, Zhou Y, Zhao WH, Yang HF. | 03/20/2021 |
| MiR-140-5p and miR-92a-3p suppress the cell proliferation, migration and invasion and promoted apoptosis in Wilms' tumor by targeting FRS2. | MiR-140-5p and miR-92a-3p suppress the cell proliferation, migration and invasion and promoted apoptosis in Wilms' tumor by targeting FRS2.
Li JL, Luo P. | 11/21/2020 |
| MiR-96 promotes apoptosis of nucleus pulpous cells by targeting FRS2. | MiR-96 promotes apoptosis of nucleus pulpous cells by targeting FRS2.
Yang X, Liu H, Zhang Q, Liu K, Yu D, Zhang Y, Shi Z. | 10/31/2020 |
| Genomic coamplification of CDK4/MDM2/FRS2 is associated with very poor prognosis and atypical clinical features in neuroblastoma patients. | Genomic coamplification of CDK4/MDM2/FRS2 is associated with very poor prognosis and atypical clinical features in neuroblastoma patients.
Amoroso L, Ognibene M, Morini M, Conte M, Di Cataldo A, Tondo A, D'Angelo P, Castellano A, Garaventa A, Lasorsa VA, Podestà M, Capasso M, Pezzolo A. | 10/31/2020 |
| Results found that FRS2 expression was downregulated in nephroblastoma tissues and cell lines. Furthermore, its expression was directly regulated by miR-200c. | miR-200c-3p Suppresses the Proliferative, Migratory, and Invasive Capacities of Nephroblastoma Cells via Targeting FRS2.
Li T, Zhao P, Li Z, Wang CC, Wang YL, Gu Q. | 02/29/2020 |
| inhibition of FGF signaling by silencing FGF receptor substrate 2 (FRS2) decreased the protein expression levels of various chemokines | FGF signaling contributes to atherosclerosis by enhancing the inflammatory response in vascular smooth muscle cells.
Qi M, Xin S., Free PMC Article | 01/4/2020 |
| the FRS2 gene is consistently amplified in classic and dedifferentiated low-grade osteosarcomas | Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis.
He X, Pang Z, Zhang X, Lan T, Chen H, Chen M, Yang H, Huang J, Chen Y, Zhang Z, Jing W, Peng R, Zhang H. | 08/31/2019 |
| Authors find recurrent ADGRG6 enhancer mutations and FRS2 duplications which are associated with higher protein expression in the tumor and poor prognosis. Functional assays demonstrate that depletion of ADGRG6 or FRS2 expression in UBC cells compromise their abilities to recruit endothelial cells and induce tube formation. | Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer.
Wu S, Ou T, Xing N, Lu J, Wan S, Wang C, Zhang X, Yang F, Huang Y, Cai Z., Free PMC Article | 04/13/2019 |
| loss of myristoylation of fibroblast growth factor receptor substrate 2 (FRS2alpha), a scaffold protein essential for FGFR signaling, inhibits FGF/FGFR-mediated oncogenic signaling and FGF10-induced tumorigenesis. Moreover, a previously synthesized myristoyl-CoA analog, B13, which targets the activity of N-myristoyltransferases. | Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression.
Li Q, Alsaidan OA, Ma Y, Kim S, Liu J, Albers T, Liu K, Beharry Z, Zhao S, Wang F, Lebedyeva I, Cai H., Free PMC Article | 12/29/2018 |
| These findings suggest that FRS2 is amplified consistently in liposarcoma. | Amplification of FRS2 in atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma: a clinicopathological and genetic study of 146 cases.
Jing W, Lan T, Chen H, Zhang Z, Chen M, Peng R, He X, Zhang H. | 09/29/2018 |
| MiR-4653-3p and its target gene FRS2 are may have roles in response of hormone receptor positive breast cancer patients to tamoxifen | MiR-4653-3p and its target gene FRS2 are prognostic biomarkers for hormone receptor positive breast cancer patients receiving tamoxifen as adjuvant endocrine therapy.
Zhong X, Xie G, Zhang Z, Wang Z, Wang Y, Wang Y, Qiu Y, Li L, Bu H, Li J, Zheng H., Free PMC Article | 03/31/2018 |
| we report for the first time that PKD1 was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 as a novel mediator of androgen-induced PKD1 repression. | Androgen suppresses protein kinase D1 expression through fibroblast growth factor receptor substrate 2 in prostate cancer cells.
Zhang L, Zhao Z, Xu S, Tandon M, LaValle CR, Deng F, Wang QJ., Free PMC Article | 10/7/2017 |
| They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies. | Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients.
Liu J, You P, Chen G, Fu X, Zeng X, Wang C, Huang Y, An L, Wan X, Navone N, Wu CL, McKeehan WL, Zhang Z, Zhong W, Wang F., Free PMC Article | 08/27/2016 |
| Results identify FRS2 as an oncogene in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications. | The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer.
Luo LY, Kim E, Cheung HW, Weir BA, Dunn GP, Shen RR, Hahn WC., Free PMC Article | 02/6/2016 |
| Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib. | The impact of FGFR1 and FRS2α expression on sorafenib treatment in metastatic renal cell carcinoma.
Ho TH, Liu XD, Huang Y, Warneke CL, Johnson MM, Hoang A, Tamboli P, Wang F, Jonasch E., Free PMC Article | 01/23/2016 |
| The signaling complex appears to integrate the input from FGFR and EphA4, and release the output signal through FRS2alpha. | Ternary complex formation of EphA4, FGFR and FRS2α plays an important role in the proliferation of embryonic neural stem/progenitor cells.
Sawada T, Jing X, Zhang Y, Shimada E, Yokote H, Miyajima M, Sakaguchi K. | 07/4/2015 |
| These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development. | Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development.
Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X., Free PMC Article | 09/20/2014 |