| Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses. | Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.
Roh WS, Yoo JH, Dravid SM, Mannaioni G, Krizman EN, Wahl P, Robinson MB, Traynelis SF, Lee CJ, Han KS., | 08/20/2024 |
| Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits. | Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits.
Dogra S, Aguayo C, Xiang Z, Putnam J, Smith J, Johnston C, Foster DJ, Lindsley CW, Niswender CM, Conn PJ., | 08/6/2024 |
| A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model. | A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model.
Turati J, Rudi J, Beauquis J, Carniglia L, López Couselo F, Saba J, Caruso C, Saravia F, Lasaga M, Durand D. | 05/21/2022 |
| Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice. | Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
Busceti CL, Ginerete RP, Di Menna L, D'Errico G, Cisani F, Di Pietro P, Imbriglio T, Bruno V, Battaglia G, Fornai F, Monn JA, Pittaluga A, Nicoletti F. | 02/5/2022 |
| Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice. | Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.
Li SH, Colson TL, Abd-Elrahman KS, Ferguson SSG. | 01/1/2022 |
| mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice. | mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.
Jing XY, Wang Y, Zou HW, Li ZL, Liu YJ, Li LF. | 12/18/2021 |
| Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors. | Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu(3)) impairs postsynaptic plasticity and modulates affective behaviors.
Joffe ME, Santiago CI, Vermudez SAD, Fisher NM, Dogra S, Niswender CM, Jeffrey Conn P., Free PMC Article | 12/4/2021 |
| Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells. | Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
Guo C, Huson V, Macosko EZ, Regehr WG., Free PMC Article | 10/30/2021 |
| mGlu3 receptor regulates microglial cell reactivity in neonatal rats. | mGlu3 receptor regulates microglial cell reactivity in neonatal rats.
Zinni M, Mairesse J, Pansiot J, Fazio F, Iacovelli L, Antenucci N, Orlando R, Nicoletti F, Vaiman D, Baud O., Free PMC Article | 10/9/2021 |
| Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus. | Activating mGlu(3) Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
Dogra S, Stansley BJ, Xiang Z, Qian W, Gogliotti RG, Nicoletti F, Lindsley CW, Niswender CM, Joffe ME, Conn PJ., Free PMC Article | 10/2/2021 |
| The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex. | The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.
Guo C, Wang C, He T, Yu B, Li M, Zhao C, Yuan Y, Chen H. | 09/25/2021 |
| hese findings suggest that mGlu3 receptors have a strong impact on the development of cortical GABAergic transmission and cortical neural synchronization mechanisms corroborating the concept that genetic variants of mGlu3 receptors may predispose to psychiatric disorders. | Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.
Imbriglio T, Verhaeghe R, Martinello K, Pascarelli MT, Chece G, Bucci D, Notartomaso S, Quattromani M, Mascio G, Scalabrì F, Simeone A, Maccari S, Del Percio C, Wieloch T, Fucile S, Babiloni C, Battaglia G, Limatola C, Nicoletti F, Cannella M. | 06/27/2020 |
| Grm3(-/-) mice did not have a stress-resilient phenotype. | Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.
Highland JN, Zanos P, Georgiou P, Gould TD., Free PMC Article | 03/21/2020 |
| Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits | Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits.
Berry S, Weinmann O, Fritz AK, Rust R, Wolfer D, Schwab ME, Gerber U, Ster J., Free PMC Article | 01/19/2019 |
| the activation of mGluR3 up-regulates the membrane expression of TWIK-1 that in turn enhances NH4(+) uptake in astrocytes. | mGluR3 Activation Recruits Cytoplasmic TWIK-1 Channels to Membrane that Enhances Ammonium Uptake in Hippocampal Astrocytes.
Wang W, Kiyoshi CM, Du Y, Ma B, Alford CC, Chen H, Zhou M., Free PMC Article | 02/3/2018 |
| These studies provide a foundation for future research seeking to parse out the roles of mGlu2 from mGlu3, paving the way for better understanding of how these receptors regulate activity in the brain. | Developmental expression of mGlu2 and mGlu3 in the mouse brain.
McOmish CE, Demireva EY, Gingrich JA., Free PMC Article | 06/3/2017 |
| provided evidence that JARID1B via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB | Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.
Pritchett D, Jagannath A, Brown LA, Tam SK, Hasan S, Gatti S, Harrison PJ, Bannerman DM, Foster RG, Peirson SN., Free PMC Article | 04/16/2016 |
| Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2+) transients and striatal field potentials. | Inhibition of presynaptic calcium transients in cortical inputs to the dorsolateral striatum by metabotropic GABA(B) and mGlu2/3 receptors.
Kupferschmidt DA, Lovinger DM., Free PMC Article | 02/13/2016 |
| Activation of Grm3 ameliorates lupus-like disease in mice by reducing B cell numbers. Grm3 expression on B-cells is decreased in lupus-prone mice. | Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells.
Ma N, Liu X, Xing C, Wang X, Wei Y, Han G, Chen G, Hou C, Shen B, Li Y, Xiao H, Wang R. | 12/19/2015 |
| The number of mGluR3-immunoractive cells was significantly reduced in the dorsal and intermediate but not ventral parts of the lateral septum in postpartum versus virgin females. | Metabotropic glutamate receptor 3 is downregulated and its expression is shifted from neurons to astrocytes in the mouse lateral septum during the postpartum period.
Zhao C, Gammie SC., Free PMC Article | 08/8/2015 |
| GRM3-knockout mice exhibit a biphasic effect in spatial working memory, initially impaired but performing better after training. | The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.
De Filippis B, Lyon L, Taylor A, Lane T, Burnet PW, Harrison PJ, Bannerman DM., Free PMC Article | 07/25/2015 |
| The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. | Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.
Walker AG, Wenthur CJ, Xiang Z, Rook JM, Emmitte KA, Niswender CM, Lindsley CW, Conn PJ., Free PMC Article | 04/25/2015 |
| This study demonistrated that mGluR3 knockout mice show a working memory defect. | mGluR3 knockout mice show a working memory defect and an enhanced response to MK-801 in the T- and Y-maze cognitive tests.
Lainiola M, Procaccini C, Linden AM. | 12/20/2014 |
| report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP cleavage in astrocytes, thus enhancing sAPPalpha production | Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage.
Durand D, Carniglia L, Beauquis J, Caruso C, Saravia F, Lasaga M. | 12/6/2014 |
| The findings support the possibility that interactions between mGlu2/3 and dopamine may be relevant to the pathophysiology and therapy of schizophrenia and other disorders | Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.
Lane TA, Boerner T, Bannerman DM, Kew JN, Tunbridge EM, Sharp T, Harrison PJ., Free PMC Article | 04/12/2014 |