| CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity. | CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.
Guo W, Wang H, Kumar Tharkeshwar A, Couthouis J, Braems E, Masrori P, Van Schoor E, Fan Y, Ahuja K, Moisse M, Jacquemyn M, Furtado Madeiro da Costa R, Gajjar M, Balusu S, Tricot T, Fumagalli L, Hersmus N, Janky R, Impens F, Vanden Berghe P, Ho R, Thal DR, Vandenberghe R, Hegde ML, Chandran S, De Strooper B, Daelemans D, Van Damme P, Van Den Bosch L, Verfaillie C., Free PMC Article | 04/17/2023 |
| NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells. | NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells.
Pavan ICB, Basei FL, Severino MB, Rosa E Silva I, Issayama LK, Mancini MCS, Góis MM, da Silva LGS, Bezerra RMN, Simabuco FM, Kobarg J., Free PMC Article | 02/11/2023 |
| Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma. | Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma.
Yang ZM, Liao B, Yang SS, Su T, Zhang J, Wang WM., Free PMC Article | 08/6/2022 |
| NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis. | NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis.
Yu Y, Shen T, Zhong X, Wang LL, Tai W, Zou Y, Qin J, Zhang Z, Zhang CL. | 03/19/2022 |
| Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression. | Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.
Adib R, Montgomery JM, Atherton J, O'Regan L, Richards MW, Straatman KR, Roth D, Straube A, Bayliss R, Moores CA, Fry AM. | 08/15/2020 |
| CircNEK6 promoted the progression of thyroid cancer through up-regulating FZD8 and activating Wnt signaling pathway by targeting miR-370-3p. | Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway.
Chen F, Feng Z, Zhu J, Liu P, Yang C, Huang R, Deng Z., Free PMC Article | 09/21/2019 |
| our results imply that Nek6 plays a facilitating role in breast cancer cell proliferation | Overexpression of NIMA-related kinase 6 (NEK6) contributes to malignant growth and dismal prognosis in Human Breast Cancer.
He Z, Ni X, Xia L, Shao Z. | 11/10/2018 |
| cis-regulatory circuits that lead to overexpression of NEK6, a mitosis-associated kinase, in human B cell lymphoma, were analyzed. | cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent.
Huang Y, Koues OI, Zhao JY, Liu R, Pyfrom SC, Payton JE, Oltz EM., Free PMC Article | 11/25/2017 |
| High NEK6 expression is associated with Cluster Amplified Centrosomes in cancer. | Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.
Sampson J, O'Regan L, Dyer MJS, Bayliss R, Fry AM. | 11/4/2017 |
| Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis. | A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.
Cullati SN, Kabeche L, Kettenbach AN, Gerber SA., Free PMC Article | 09/30/2017 |
| our studies establish NEK6 signaling as a central mechanism mediating castration-resistant prostate cancer | Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6.
Choudhury AD, Schinzel AC, Cotter MB, Lis RT, Labella K, Lock YJ, Izzo F, Guney I, Bowden M, Li YY, Patel J, Hartman E, Carr SA, Schenone M, Jaffe JD, Kantoff PW, Hammerman PS, Hahn WC., Free PMC Article | 07/29/2017 |
| overexpression of PAK1, NEK6, AURKA, and AURKB genes in patients with Colorectal adenomatous polyp and colorectal cancer in the Turkish population. | The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma.
Kasap E, Gerceker E, Boyacıoglu SÖ, Yuceyar H, Yıldırm H, Ayhan S, Korkmaz M. | 02/18/2017 |
| We found that NEK6-mediated phosphorylation of TPP1 Ser255 in G2/M phase regulates the association between telomerase activity and TPP1. Furthermore, we found evidence that POT1 negatively regulates TPP1 phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 mutant lacking its OB-fold domains | NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment.
Hirai Y, Tamura M, Otani J, Ishikawa F. | 02/18/2017 |
| Overexpression of AURKA and NEK6 genes was significantly more pronounced in Ulcerative colitis patients with more extensive colon involvement | Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer.
Gerçeker E, Boyacıoglu SO, Kasap E, Baykan A, Yuceyar H, Yıldırım H, Ayhan S, Ellidokuz E, Korkmaz M. | 06/11/2016 |
| NEK6 suppresses the cell growth arrest induced by TGFbeta. Mechanically, NEK6 blocks nuclear translocation of Smad4, which is essential for TGFbeta function. | An inhibitory role of NEK6 in TGFβ/Smad signaling pathway.
Zuo J, Ma H, Cai H, Wu Y, Jiang W, Yu L., Free PMC Article | 06/4/2016 |
| Nek6 is also a critical signaling molecule that helps prevent cardiac hypertrophy and inhibits the Akt signaling pathway. | Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy.
Bian Z, Liao H, Zhang Y, Wu Q, Zhou H, Yang Z, Fu J, Wang T, Yan L, Shen D, Li H, Tang Q., Free PMC Article | 08/1/2015 |
| Nek6 facilitates association of Hsp72 with the mitotic spindle, where it promotes stable K-fiber assembly through recruitment of the ch-TOG-TACC3 complex. | Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.
O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM., Free PMC Article | 08/1/2015 |
| Nek6 plays an important role in the premature senescence of cancer cells. | The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment.
Jee HJ, Kim HJ, Kim AJ, Song N, Kim M, Lee HJ, Yun J. | 07/27/2013 |
| High Nek6 is associated with hepatic cell cancer. | Clinical and biological significance of never in mitosis gene A-related kinase 6 (NEK6) expression in hepatic cell cancer.
Cao X, Xia Y, Yang J, Jiang J, Chen L, Ni R, Li L, Gu Z. | 08/4/2012 |
| Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. | Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.
Bertran MT, Sdelci S, Regué L, Avruch J, Caelles C, Roig J., Free PMC Article | 09/17/2011 |
| the first low resolution 3D structure of hNek6 protein in solution | Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain.
Meirelles GV, Silva JC, Mendonça Yde A, Ramos CH, Torriani IL, Kobarg J., Free PMC Article | 09/3/2011 |
| These results suggest that the increased expression of Nek6 renders cancer cells resistant to premature senescence, and targeting Nek6 could be an efficient strategy for cancer treatment. | Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatment.
Jee HJ, Kim HJ, Kim AJ, Song N, Kim M, Yun J. | 08/6/2011 |
| DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. | DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.
Regué L, Sdelci S, Bertran MT, Caelles C, Reverter D, Roig J., Free PMC Article | 07/30/2011 |
| Findings open new perspectives in the study of hNek6 role in cancer by analyzing its novel interactions in specific pathways in tumor cells, which may provide important implications for drug design and cancer therapy. | Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
Vaz Meirelles G, Ferreira Lanza DC, da Silva JC, Santana Bernachi J, Paes Leme AF, Kobarg J. | 05/28/2011 |
| NEK6 expression is downregulated in both replicative and premature senscence of human cnacer cells, and the inhibition of Nek6 activity is important for the onset of cellular senescence. | Nek6 overexpression antagonizes p53-induced senescence in human cancer cells.
Jee HJ, Kim AJ, Song N, Kim HJ, Kim M, Koh H, Yun J. | 04/16/2011 |