| C3G Regulates STAT3, ERK, Adhesion Signaling, and Is Essential for Differentiation of Embryonic Stem Cells. | C3G Regulates STAT3, ERK, Adhesion Signaling, and Is Essential for Differentiation of Embryonic Stem Cells.
Vishnu VV, Muralikrishna B, Verma A, Nayak SC, Sowpati DT, Radha V, Shekar PC., Free PMC Article | 03/5/2022 |
| Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells. | Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells.
Chavkin NW, Leaf EM, Brooks KE, Wallingford MC, Lund SM, Giachelli CM., Free PMC Article | 12/25/2021 |
| C3G contributes to platelet activation and aggregation by regulating major signaling pathways. | C3G contributes to platelet activation and aggregation by regulating major signaling pathways.
Gutiérrez-Herrero S, Fernández-Infante C, Hernández-Cano L, Ortiz-Rivero S, Guijas C, Martín-Granado V, González-Porras JR, Balsinde J, Porras A, Guerrero C., Free PMC Article | 10/16/2021 |
| C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length. | C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.
Nayak SC, Radha V. | 07/31/2021 |
| C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process. | C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development.
Shah B, Lutter D, Bochenek ML, Kato K, Tsytsyura Y, Glyvuk N, Sakakibara A, Klingauf J, Adams RH, Püschel AW., Free PMC Article | 03/18/2017 |
| results provide evidence that C3G plays an important role in myogenic differentiation by coordinating cell cycle exit, actin dynamics and survival signaling. | C3G (RapGEF1), a regulator of actin dynamics promotes survival and myogenic differentiation of mouse mesenchymal cells.
Sasi Kumar K, Ramadhas A, Nayak SC, Kaniyappan S, Dayma K, Radha V. | 12/5/2015 |
| C3G regulates sympathetic preganglionic neuron migration by acting downstream in the reelin signaling pathway. | Migration of sympathetic preganglionic neurons in the spinal cord of a C3G-deficient mouse suggests that C3G acts in the reelin signaling pathway.
Yip YP, Thomas T, Voss AK, Yip JW. | 03/9/2013 |
| Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling. | Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics.
Ferrando IM, Chaerkady R, Zhong J, Molina H, Jacob HK, Herbst-Robinson K, Dancy BM, Katju V, Bose R, Zhang J, Pandey A, Cole PA., Free PMC Article | 12/22/2012 |
| GEF and Dlx1/2 form part of a common signalling pathway during GABAergic neuronal development. | Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder.
Bithell A, Hsu T, Kandanearatchi A, Landau S, Everall IP, Tsuang MT, Chana G, Williams BP., Free PMC Article | 06/18/2011 |
| Guanine nucleotide releasing factor 2 is a negative regulator of Mitogen-Activated Protein Kinase 14 in mouse embryonic fibroblasts and can promote cell survival or cell death depending on the stimuli. | C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: involvement in cell death.
Gutiérrez-Uzquiza A, Arechederra M, Molina I, Baños R, Maia V, Benito M, Guerrero C, Porras A. | 03/15/2010 |
| C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment. | C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment.
Voss AK, Britto JM, Dixon MP, Sheikh BN, Collin C, Tan SS, Thomas T. | 01/21/2010 |
| roles of C3G-Rap1 signaling pathway in various biological processes | Rap1 mutants with increased affinity for the guanine-nucleotide exchange factor C3G.
Shi S, Noda M, Kitayama H. | 01/21/2010 |
| Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development. | Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.
Fernández-Medarde A, Esteban LM, Núñez A, Porteros A, Tessarollo L, Santos E., Free PMC Article | 01/21/2010 |
| These results show that C3G is required for (1) vascular myogenesis, (2) the formation of paxillin- and integrin beta1-positive, but not integrin beta3-positive, cell adhesions and (3) normal response to PDGF, necessary for vascular myogenesis. | The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation.
Voss AK, Gruss P, Thomas T. | 01/21/2010 |
| Our results show that the size of the cortical neural precursor population is controlled by C3G-mediated inhibition of the Ras signalling pathway. | C3G regulates the size of the cerebral cortex neural precursor population.
Voss AK, Krebs DL, Thomas T., Free PMC Article | 01/21/2010 |