| NF-kappaB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer. | NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer.
Wang S, Kuai Y, Lin S, Li L, Gu Q, Zhang X, Li X, He Y, Chen S, Xia X, Ruan Z, Lin C, Ding Y, Zhang Q, Qi C, Li J, He X, Pathak JL, Zhou W, Liu S, Wang L, Zheng L., Free PMC Article | 04/1/2023 |
| alphaCT1 peptide sensitizes glioma cells to temozolomide in a glioblastoma organoid platform. | αCT1 peptide sensitizes glioma cells to temozolomide in a glioblastoma organoid platform.
Che J, DePalma TJ, Sivakumar H, Mezache LS, Tallman MM, Venere M, Swindle-Reilly K, Veeraraghavan R, Skardal A. | 03/19/2023 |
| TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation, migration, and extracellular matrix deposition in keloid through the TGF-beta1/Smad pathway. | TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation, migration, and extracellular matrix deposition in keloid through the TGF-β1/Smad pathway.
Yan Q, Li B. | 11/5/2022 |
| A multilocus genetic study evidences the association of autoimmune-related genes with Psoriatic Arthritis in Italian patients. | A multilocus genetic study evidences the association of autoimmune-related genes with Psoriatic Arthritis in Italian patients.
De Benedittis G, Latini A, Conigliaro P, Triggianese P, Bergamini A, Novelli L, Ciccacci C, Chimenti MS, Borgiani P. | 08/6/2022 |
| A Novel TRAF3IP2 Mutation Causing Chronic Mucocutaneous Candidiasis. | A Novel TRAF3IP2 Mutation Causing Chronic Mucocutaneous Candidiasis.
Marujo F, Pelham SJ, Freixo J, Cordeiro AI, Martins C, Casanova JL, Lei WT, Puel A, Neves JF., Free PMC Article | 02/5/2022 |
| Two patients with chronic mucocutaneous candidiasis caused by TRAF3IP2 deficiency. | Two patients with chronic mucocutaneous candidiasis caused by TRAF3IP2 deficiency.
Shafer S, Yao Y, Comrie W, Cook S, Zhang Y, Yesil G, Karakoç-Aydiner E, Baris S, Cokugras H, Aydemir S, Kiykim A, Ozen A, Lenardo M., Free PMC Article | 10/16/2021 |
| Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. | Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.
Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, Jacobs K, Broux M, Verhoef G, Michaux L, Graux C, Wlodarska I, Gaulard P, de Leval L, Tousseyn T, Cools J, Dierickx D., Free PMC Article | 07/10/2021 |
| A novel TRAF3IP2 variant causing familial scarring alopecia with mixed features of discoid lupus erythematosus and folliculitis decalvans. | A novel TRAF3IP2 variant causing familial scarring alopecia with mixed features of discoid lupus erythematosus and folliculitis decalvans.
Nemer G, El-Hachem N, Eid E, Hamie L, Bardawil T, Khalil S, El-Rassy I, Safi R, Khalil A, Abbas O, Shimomura Y, Kurban M. | 07/10/2021 |
| Overexpression of SNTG2, TRAF3IP2, and ITGA6 transcripts is associated with osteoporotic vertebral fracture in elderly women from community. | Overexpression of SNTG2, TRAF3IP2, and ITGA6 transcripts is associated with osteoporotic vertebral fracture in elderly women from community.
Jales Neto LH, Wicik Z, Torres GHF, Takayama L, Caparbo VF, Lopes NHM, Pereira AC, Pereira RMR., Free PMC Article | 05/29/2021 |
| Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration. | Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration.
Lindstrom SI, Sigurdardottir S, Zapadka TE, Tang J, Liu H, Taylor BE, Smith DG, Lee CA, DeAngelis J, Kern TS, Taylor PR., Free PMC Article | 11/21/2020 |
| We describe an adolescent boy with recurrent oral candidiasis and bronchiectasis due to a novel mutation in TRAF3IP2 gene, not reported to date. This is also the only second report of CMC due to ACT1 deficiency. | Chronic Mucocutaneous Candidiasis in an Adolescent Boy Due to a Novel Mutation in TRAF3IP2.
Bhattad S, Dinakar C, Pinnamaraju H, Ganapathy A, Mannan A. | 07/11/2020 |
| increased MMP-13 and decreased RECK contribute to IL-17A-induced TRAF3IP2-dependent smooth muscle cell migration and proliferation. | RECK suppresses interleukin-17/TRAF3IP2-mediated MMP-13 activation and human aortic smooth muscle cell migration and proliferation.
Mummidi S, Das NA, Carpenter AJ, Yoshida T, Yariswamy M, Mostany R, Izadpanah R, Higashi Y, Sukhanov S, Noda M, Siebenlist U, Rector RS, Chandrasekar B., Free PMC Article | 06/20/2020 |
| Study results implicate neutrophil extracellular traps (NETs) and the T allele of rs33980500 (T/C), a psoriasis risk-associated variant in the TRAF3IP2 gene encoding the D10N variant of Act1, in human Th17 induction from peripheral blood mononuclear cells and verified that the effect of Act1 D10N was greater in the presence of NETs. | Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype.
Lambert S, Hambro CA, Johnston A, Stuart PE, Tsoi LC, Nair RP, Elder JT., Free PMC Article | 05/9/2020 |
| We also identify a novel LRI site located within the TRAF3IP2-AS1 promoter, 200 kb distant from the TRAF3IP2 promoter, showing genetic association with psoriasis both in our discovery cohort, as well as in the large WTCCC replication cohort. | Candidate long-range regulatory sites acting on the IL17 pathway genes TRAF3IP2 and IL17RA are associated with psoriasis.
Nititham J, Fergusson C, Palmer C, Liao W, Foerster J. | 08/17/2019 |
| Act1 D10N missense mutation impairs CD40L-induced phosphorylation of p65, p38, and Erk in B-cells. | The Act1 D10N missense variant impairs CD40 signaling in human B-cells.
Yu N, Lambert S, Bornstein J, Nair RP, Enerbäck C, Elder JT., Free PMC Article | 04/6/2019 |
| Four genes-ACT1, PIN1, DNMT1 and NTN1-emerged as having roles in pathways that may influence Primary Biliary Cholangitis pathogenesis in British Columbia First Nations people. | Primary Biliary Cholangitis in British Columbia First Nations: Clinical features and discovery of novel genetic susceptibility loci.
Asuri S, McIntosh S, Taylor V, Rokeby A, Kelly J, Shumansky K, Field LL, Yoshida EM, Arbour L. | 01/12/2019 |
| AP1 binding sites were enriched upstream of genes up-regulated by TRAF3IP2 silencing. Correspondingly, nuclear expression of FosB and Fra1 was increased in TRAF3IP2-silenced cells. Many genes involved in host defense were induced by IL-17 in a TRAF3IP2-dependent fashion. | Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses.
Lambert S, Swindell WR, Tsoi LC, Stoll SW, Elder JT., Free PMC Article | 09/16/2017 |
| TRAF3IP2 SNP rs33980500 associated with no achievement of low disease activity nor remission at 6 months | Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.
Conigliaro P, Ciccacci C, Politi C, Triggianese P, Rufini S, Kroegler B, Perricone C, Latini A, Novelli G, Borgiani P, Perricone R., Free PMC Article | 08/31/2017 |
| the first report to describe a non-adaptor function of Act1 by directly binding to the promoter region of IL-17A responsive genes and directly regulate their transcription. | A Novel Nuclear Function for the Interleukin-17 Signaling Adaptor Protein Act1.
Velichko S, Zhou X, Zhu L, Anderson JD, Wu R, Chen Y., Free PMC Article | 04/29/2017 |
| ACT1 is an essential adaptor molecule of Il-17-induced expression of inflammation-related gene targets. | Increased Act1/IL-17R expression in Hirschsprung's disease.
Tomuschat C, O'Donnell AM, Coyle D, Puri P. | 04/1/2017 |
| Both the ACT-1 assay and the MAdCAM-1 assay demonstrated acceptable reproducibility and repeatability. The assays were sufficiently stable to allow for clinical use. During clinical testing the assays demonstrated that vedolizumab was able to saturate peripheral cells at all doses tested. | Development and validation of receptor occupancy pharmacodynamic assays used in the clinical development of the monoclonal antibody vedolizumab.
Wyant T, Estevam J, Yang L, Rosario M. | 12/24/2016 |
| A G/G genotype of rs766748 in IL-17F, and a C/C or C/A genotype of rs1883136 in TRAF3IP2. | Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn's Disease.
Urabe S, Isomoto H, Ishida T, Maeda K, Inamine T, Kondo S, Higuchi N, Sato K, Uehara R, Yajima H, Machida H, Chen CC, Fukuda Y, Takeshima F, Nakao K, Tsukamoto K., Free PMC Article | 08/27/2016 |
| The suppressive effects of miR-30a were mediated by directly targeting Traf3ip2 mRNA | The miR-30a Negatively Regulates IL-17-Mediated Signal Transduction by Targeting Traf3ip2.
Wan Q, Zhou Z, Ding S, He J. | 08/20/2016 |
| TRAF3IP2 may play a causal role in aldosterone-induced adverse cardiac remodeling in vivo. | Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2.
Somanna NK, Yariswamy M, Garagliano JM, Siebenlist U, Mummidi S, Valente AJ, Chandrasekar B. | 06/4/2016 |
| Single nucleotide polymorphisms in RBPJ, IL1R1, REV3L, TRAF3IP2, IRF1 and ICOS showed association with rheumatoid arthritis in black South Africans. | Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.
Govind N, Choudhury A, Hodkinson B, Ickinger C, Frost J, Lee A, Gregersen PK, Reynolds RJ, Bridges SL Jr, Hazelhurst S, Ramsay M, Tikly M., Free PMC Article | 12/12/2015 |