| NIK-mediated reactivation of SIX2 enhanced the CSC-like traits of hepatocellular carcinoma cells through suppressing ubiquitin-proteasome system. | NIK-mediated reactivation of SIX2 enhanced the CSC-like traits of hepatocellular carcinoma cells through suppressing ubiquitin-proteasome system.
Daren L, Dan Y, Jinhong W, Chao L. | 01/15/2024 |
| De novo SIX2 activation in human kidneys treated with neonatal kidney stem/progenitor cells. | De novo SIX2 activation in human kidneys treated with neonatal kidney stem/progenitor cells.
Arcolino FO, Hosgood S, Akalay S, Jordan N, Herman J, Elliott T, Veys K, Vermeire K, Sprangers B, Nicholson M, van den Heuvel L, Levtchenko E., Free PMC Article | 12/10/2022 |
| Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse. | Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.
Ciceri S, Montalvão-de-Azevedo R, Tajbakhsh A, Bertolotti A, Spagnuolo RD, Boschetti L, Capasso M, D'Angelo P, Serra A, Diomedi-Camassei F, Meli M, Nantron M, Quarello P, Buccoliero AM, Tamburini A, Ciniselli CM, Verderio P, Collini P, Radice P, Spreafico F, Perotti D. | 02/26/2022 |
| Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma. | Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma.
Jiang Y, Zhou B, Liang B, Zeng F, Zou Z. | 06/12/2021 |
| SIX2 Regulates Human beta Cell Differentiation from Stem Cells and Functional Maturation In Vitro. | SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro.
Velazco-Cruz L, Goedegebuure MM, Maxwell KG, Augsornworawat P, Hogrebe NJ, Millman JR., Free PMC Article | 05/22/2021 |
| Maternal SLE and brachytelephalangic chondrodysplasia punctata in a patient with unrelated de novo RAF1 and SIX2 variants. | Maternal SLE and brachytelephalangic chondrodysplasia punctata in a patient with unrelated de novo RAF1 and SIX2 variants.
Alkhunaizi E, Unger S, Shannon P, Nishimura G, Blaser S, Chitayat D. | 05/1/2021 |
| The six2 knockdown attenuated the stemness of Renal cell carcinoma (RCC) cells, which was evident by decreased spheroid formation ability and stemness marker (sox2 and nanog) expression. | Transcription factor Six2 induces a stem cell-like phenotype in renal cell carcinoma cells.
Cheng N, Li H, Han Y, Sun S., Free PMC Article | 05/9/2020 |
| Elevated Six2 expression in hepatocellular carcinoma patients was associated with negative prognosis. Upregulated Six2 promoted tumor growth and facilitated HCC metastasis via TGF-beta/Smad signal pathway. | Six2 is negatively correlated with prognosis and facilitates epithelial-mesenchymal transition via TGF-β/Smad signal pathway in hepatocellular carcinoma.
Wan ZH, Ma YH, Jiang TY, Lin YK, Shi YY, Tan YX, Dong LW, Wang HY. | 05/2/2020 |
| Glomerular Six-2 deposits in renal biopsy should be validated in prospective series as a predictor of renal outcome in renal amyloidosis | Six-2 glomerular expression for the prediction of renal outcome in systemic amyloidosis.
Rodas LM, Garcia-Herrera A, Ramirez Bajo M, Fernandez-Larrea C, Cibeira MT, Blasco M, Rosiñol L, Solé M, Blade J, Campistol JM, Quintana LF. | 02/1/2020 |
| High Six2 expression is associated with Late-Stage Metastasis in triple-negative breast cancer. | SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program.
Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL., Free PMC Article | 12/14/2019 |
| findings identify a NIK-SIX signalling axis that fine-tunes inflammatory gene expression programs under both physiological and pathological conditions | A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.
Liu Z, Mar KB, Hanners NW, Perelman SS, Kanchwala M, Xing C, Schoggins JW, Alto NM., Free PMC Article | 12/7/2019 |
| Six2 expression negatively correlated with the overall survival of clear cell renal cell carcinoma patients. | PPARG Negatively Modulates Six2 in Tumor Formation of Clear Cell Renal Cell Carcinoma.
Wu Y, Song T, Liu M, He Q, Chen L, Liu Y, Ni D, Liu J, Hu Y, Gu Y, Li Q, Zhou Q, Xie Y. | 07/20/2019 |
| Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in HCC cells. | Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells.
Li JW, Huang CZ, Li JH, Yuan JH, Chen QH, Zhang WF, Xu ZS, Liu YP, Li Y, Zhan MX, Lu LG. | 10/13/2018 |
| the phenotypic spectrum of SIX2 haploinsufficiency is widened. Moreover, 2p21 microdeletions with SIX2 haploinsufficiency appear to lead to a recognizable phenotype with facial features resembling blepharophimosis-ptosis-epicanthus inversus syndrome. | SIX2 gene haploinsufficiency leads to a recognizable phenotype with ptosis, frontonasal dysplasia, and conductive hearing loss.
Henn A, Weng H, Novak S, Rettenberger G, Gerhardinger A, Rossier E, Zirn B. | 09/8/2018 |
| DDX3-mediated colorectal cancer aggressiveness and cetuximab resistance were regulated by the YAP1/SIX2 axis in KRAS-wild type cells and further confirmed in animal models. | The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer.
Wu DW, Lin PL, Wang L, Huang CC, Lee H., Free PMC Article | 01/6/2018 |
| elevated expressions of SIX2, SIX4, and SIX6 predicted poor overall survival (OS) in NSCLC and poor relapse-free survival (RFS) in lung adenocarcinoma | The expression profile and clinic significance of the SIX family in non-small cell lung cancer.
Liu Q, Li A, Tian Y, Liu Y, Li T, Zhang C, Wu JD, Han X, Wu K., Free PMC Article | 12/2/2017 |
| these findings delineate the important function of the TGFbeta signaling pathway in the early development of kidney and TbetaRII was shown to be able to promote the expression of Six2 through Smad3 mediating transcriptional regulation and in turn activate the proliferation of MM cells. | TβRII Regulates the Proliferation of Metanephric Mesenchyme Cells through Six2 In Vitro.
Mao Z, Lyu Z, Huang L, Zhou Q, Weng Y., Free PMC Article | 07/1/2017 |
| We suggest SIX2 haploinsufficiency as a potential congenital factor could be attributed to developmental malformation of the middle ear ossicles and upper eyelid. | SIX2 haploinsufficiency causes conductive hearing loss with ptosis in humans.
Guan J, Wang D, Cao W, Zhao Y, Du R, Yuan H, Liu Q, Lan L, Zong L, Yang J, Yin Z, Han B, Zhang F, Wang Q., Free PMC Article | 04/8/2017 |
| SIX2 deletion is associated with frontonasal dysplasia syndrome. | A new frontonasal dysplasia syndrome associated with deletion of the SIX2 gene.
Hufnagel RB, Zimmerman SL, Krueger LA, Bender PL, Ahmed ZM, Saal HM., Free PMC Article | 10/29/2016 |
| These data suggest differential SIX-factor regulation might have contributed to species differences in nephron progenitor programs such as the duration of nephrogenesis and the final nephron count | Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.
O'Brien LL, Guo Q, Lee Y, Tran T, Benazet JD, Whitney PH, Valouev A, McMahon AP., Free PMC Article | 07/16/2016 |
| SIX2 overexpression and concomitantly decreased promoter methylation. | Assessment of promoter methylation and expression of SIX2 as a diagnostic and prognostic biomarker in Wilms' tumor.
Song D, Yue L, Wu G, Ma S, Guo L, Yang H, Liu Q, Zhang D, Xia Z, Wang L, Zhang J, Zhao W, Guo F, Wang J. | 01/23/2016 |
| Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA/DGCR8 microprocessor genes | Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.
Wegert J, Ishaque N, Vardapour R, Geörg C, Gu Z, Bieg M, Ziegler B, Bausenwein S, Nourkami N, Ludwig N, Keller A, Grimm C, Kneitz S, Williams RD, Chagtai T, Pritchard-Jones K, van Sluis P, Volckmann R, Koster J, Versteeg R, Acha T, O'Sullivan MJ, Bode PK, Niggli F, Tytgat GA, van Tinteren H, van den Heuvel-Eibrink MM, Meese E, Vokuhl C, Leuschner I, Graf N, Eils R, Pfister SM, Kool M, Gessler M. | 04/25/2015 |
| in tumors with DGCR8 E518K and DROSHA exon 29 (miRNAPG-HS) mutations ... greater prevalence of tumors with blastemal predominant histology in patients with miRNAPG-HS and/or SIX1/2 Q177R mutations | Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.
Walz AL, Ooms A, Gadd S, Gerhard DS, Smith MA, Guidry Auvil JM, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Bowlby R, Brooks D, Ma Y, Mungall AJ, Moore RA, Schein J, Marra MA, Huff V, Dome JS, Chi YY, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Jafari N, Ross N, Gastier-Foster JM, Perlman EJ., Free PMC Article | 04/25/2015 |
| Nuclear protein & mRNA expression of SIX2 were similar across all stages of disease, in favorable or unfavorable histology & in treatment failure or success. It is not found in normal kidney. | SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.
Murphy AJ, Pierce J, de Caestecker C, Taylor C, Anderson JR, Perantoni AO, de Caestecker MP, Lovvorn HN 3rd., Free PMC Article | 11/3/2012 |
| Lack of mutations in the coding regions of SIX2 among the sporadic microtia patients | Mutational analysis of HOXA2 and SIX2 in a Bronx population with isolated microtia.
Monks DC, Jahangir A, Shanske AL, Samanich J, Morrow BE, Babcock M. | 01/29/2011 |