| The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13. | The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.
Shi L, Luo B, Deng L, Zhang Q, Li Y, Sun D, Zhang H, Zhuang L. | 06/5/2024 |
| Overexpressed Galpha13 activates serum response factor through stoichiometric imbalance with Gbetagamma and mislocalization to the cytoplasm. | Overexpressed Gα13 activates serum response factor through stoichiometric imbalance with Gβγ and mislocalization to the cytoplasm.
Hasan S, White NF, Tagliatela AC, Durall RT, Brown KM, McDiarmid GR, Meigs TE. | 01/7/2023 |
| The role of genes affected by human evolution marker GNA13 in schizophrenia. | The role of genes affected by human evolution marker GNA13 in schizophrenia.
Xiang B, Yang J, Zhang J, Yu M, Huang C, He W, Lei W, Chen J, Liu K. | 11/27/2021 |
| GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner. | GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
Xia Z, Zhang X, Liu P, Zhang R, Huang Z, Li D, Xiao X, Wu M, Ning N, Zhang Q, Zhang J, Liu M, Jiao B, Ren R., Free PMC Article | 10/9/2021 |
| Divergent C-terminal motifs in Galpha12 and Galpha13 provide distinct mechanisms of effector binding and SRF activation. | Divergent C-terminal motifs in Gα12 and Gα13 provide distinct mechanisms of effector binding and SRF activation.
Stecky RC, Quick CR, Fleming TL, Mull ML, Vinson VK, Whitley MS, Dover EN, Meigs TE. | 08/7/2021 |
| Naturally occurring hotspot cancer mutations in Galpha13 promote oncogenic signaling. | Naturally occurring hotspot cancer mutations in Gα(13) promote oncogenic signaling.
Maziarz M, Federico A, Zhao J, Dujmusic L, Zhao Z, Monti S, Varelas X, Garcia-Marcos M., Free PMC Article | 05/8/2021 |
| Galphas directly drives PDZ-RhoGEF signaling to Cdc42. | Gα(s) directly drives PDZ-RhoGEF signaling to Cdc42.
Castillo-Kauil A, García-Jiménez I, Cervantes-Villagrana RD, Adame-García SR, Beltrán-Navarro YM, Gutkind JS, Reyes-Cruz G, Vázquez-Prado J., Free PMC Article | 04/13/2021 |
| G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. | G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.
Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA., Free PMC Article | 01/23/2021 |
| these findings suggest that GNA13 drives CXCL5 expression by transactivating NF-kappaB in a Rho-dependent manner in prostate cancer cells. | Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB.
Lim WK, Chai X, Ghosh S, Ray D, Wang M, Rasheed SAK, Casey PJ., Free PMC Article | 06/13/2020 |
| Signaling mechanisms and physiological functions of G-protein Galpha13 in blood vessel formation, bone homeostasis, and cancer. | Signaling mechanisms and physiological functions of G-protein Gα(13) in blood vessel formation, bone homeostasis, and cancer.
Syrovatkina V, Huang XY., Free PMC Article | 01/25/2020 |
| GNA13 protein expression was an independent prognostic factor and may affect disease progression in follicular lymphoma. | Analysis of GNA13 Protein in Follicular Lymphoma and its Association With Poor Prognosis.
Shimono J, Miyoshi H, Yoshida N, Kato T, Sato K, Sugio T, Miyawaki K, Kurita D, Sasaki Y, Kawamoto K, Imaizumi Y, Kato K, Nagafuji K, Akashi K, Seto M, Teshima T, Ohshima K., Free PMC Article | 09/7/2019 |
| GTPase-deficient G-ALPHA-qQL and Galpha13QL variants formed stable complexes with G protein beta gamma, impairing its interaction with P-REX1. | Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gα(q) and Gα(13) proteins.
Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J., Free PMC Article | 05/4/2019 |
| GNA13 expression is a potential prognostic biomarker for tumor progression, and interfering with GNA13-induced signaling provides a novel strategy to block Tumor-initiating phenotypes and drug resistance in head and neck squamous cell carcinoma. | GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.
Rasheed SAK, Leong HS, Lakshmanan M, Raju A, Dadlani D, Chong FT, Shannon NB, Rajarethinam R, Skanthakumar T, Tan EY, Hwang JSG, Lim KH, Tan DS, Ceppi P, Wang M, Tergaonkar V, Casey PJ, Iyer NG., Free PMC Article | 03/16/2019 |
| High expression of GNA13 is associated with hepatocellular carcinoma. | High expression of GNA13 is associated with poor prognosis in hepatocellular carcinoma.
Xu Y, Rong J, Duan S, Chen C, Li Y, Peng B, Yi B, Zheng Z, Gao Y, Wang K, Yun M, Weng H, Zhang J, Ye S., Free PMC Article | 06/30/2018 |
| The ability of enhanced GNA13 signaling to suppress KLK gene expression appears at least in part due to the ability of enhanced GNA13 signaling to negatively impact Rho/ROCK-signaling. | The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.
Teo CR, Casey PJ, Rasheed SA. | 12/2/2017 |
| the selective expression of FZD10 in brain vascular endothelial cells points at a potential role of FZD10-Galpha13 signalling in central nervous system angiogenesis. | FZD(10)-Gα(13) signalling axis points to a role of FZD(10) in CNS angiogenesis.
Hot B, Valnohova J, Arthofer E, Simon K, Shin J, Uhlén M, Kostenis E, Mulder J, Schulte G. | 12/2/2017 |
| The protein profile indicates attenuation of "GNA13-ERK signaling" in schizophrenia brain. In particular, EIF4G2 and CYFIP1, which are located downstream of the GNA13-ERK network, were decreased, suggesting that the attenuation of this signal network may cause impairment of axon formation and synapse plasticity in the brain of schizophrenia patients. | Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.
Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S. | 12/2/2017 |
| Findings indicate a tumor suppressive role for G protein subunit alpha 13 (Galpha13) and rhoA GTP-binding protein (RhoA) in Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL). | Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.
O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS., Free PMC Article | 09/16/2017 |
| Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13) | Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα(13).
Scherer SL, Cain MD, Kanai SM, Kaltenbronn KM, Blumer KJ., Free PMC Article | 07/8/2017 |
| Upregulation of GNA13 expression increased the proliferation and tumorigenicity of gastric cancer. | GNA13 as a prognostic factor and mediator of gastric cancer progression.
Zhang JX, Yun M, Xu Y, Chen JW, Weng HW, Zheng ZS, Chen C, Xie D, Ye S., Free PMC Article | 11/5/2016 |
| Knockdown DDR1 reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen. | Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by Gα13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling.
Chow CR, Ebine K, Knab LM, Bentrem DJ, Kumar K, Munshi HG., Free PMC Article | 08/27/2016 |
| RGS22 acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13. | RGS22 inhibits pancreatic adenocarcinoma cell migration through the G12/13 α subunit/F-actin pathway.
Hu Y, Xing J, Chen L, Zheng Y, Zhou Z. | 07/30/2016 |
| Galpha13 Switch Region 2 Binds to the Talin Head Domain and Activates alphaIIbbeta3 Integrin in Human Platelets | Gα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets.
Srinivasan S, Schiemer J, Zhang X, Chishti AH, Le Breton GC., Free PMC Article | 01/16/2016 |
| GNA13 expression in breast cancer cells is regulated by post-transcriptional mechanisms involving miR-31. | MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells.
Rasheed SA, Teo CR, Beillard EJ, Voorhoeve PM, Zhou W, Ghosh S, Casey PJ., Free PMC Article | 01/16/2016 |
| Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1) at extracellular loop 2 (ECL2) controls G12/13 versus Gq G-proteins coupling specificity in response to thrombin stimulation. | N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.
Soto AG, Smith TH, Chen B, Bhattacharya S, Cordova IC, Kenakin T, Vaidehi N, Trejo J., Free PMC Article | 10/31/2015 |