| SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE[-/-] mice. | SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice.
Guo L, Yuan H, Zhu H, Zhou J, Wan Z, Zhou Y., Free PMC Article | 08/22/2024 |
| SPAG5 promotes the proliferation, migration, invasion, and epithelial-mesenchymal transformation of colorectal cancer cells by activating the PI3K/AKT signaling pathway. | SPAG5 promotes the proliferation, migration, invasion, and epithelial-mesenchymal transformation of colorectal cancer cells by activating the PI3K/AKT signaling pathway.
Zhang X, Wu W, Li X, He F, Zhang L. | 11/25/2023 |
| SPAG5, the upstream protein of Wnt and the target of curcumin, inhibits hepatocellular carcinoma. | SPAG5, the upstream protein of Wnt and the target of curcumin, inhibits hepatocellular carcinoma.
Li H, Qin Y, Huang Y, Wang J, Ren B., Free PMC Article | 08/7/2023 |
| SPAG5 as a novel biomarker and potential therapeutic target via regulating AKT pathway in multiple myeloma. | SPAG5 as a novel biomarker and potential therapeutic target via regulating AKT pathway in multiple myeloma.
Zeng X, Xu W, Tong J, Liu J, Zhang Z, Liu M, Wu C, Yu Q, Ye C, Wu C, Wu Y, Yan H. | 11/19/2022 |
| Downregulation of sperm-associated antigen 5 inhibits melanoma progression by regulating forkhead box protein M1/A disintegrin and metalloproteinase 17/NOTCH1 signaling. | Downregulation of sperm-associated antigen 5 inhibits melanoma progression by regulating forkhead box protein M1/A disintegrin and metalloproteinase 17/NOTCH1 signaling.
Dang L, Shi C, Zhang Q, Liao P, Wang Y., Free PMC Article | 04/16/2022 |
| CircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis. | CircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis.
Wang G, Jiang Y, Lu C, Jiang W, Wu S, Hua Y., Free PMC Article | 01/29/2022 |
| MiR-133a-3p attenuates resistance of non-small cell lung cancer cells to gefitinib by targeting SPAG5. | MiR-133a-3p attenuates resistance of non-small cell lung cancer cells to gefitinib by targeting SPAG5.
Li Q, Wang Y, He J., Free PMC Article | 12/25/2021 |
| MicroRNA-367-3p overexpression represses the proliferation and invasion of cervical cancer cells through downregulation of SPAG5-mediated Wnt/beta-catenin signalling. | MicroRNA-367-3p overexpression represses the proliferation and invasion of cervical cancer cells through downregulation of SPAG5-mediated Wnt/β-catenin signalling.
Yang T, Tian S, Wang L, Wang Y, Zhao J. | 07/17/2021 |
| Expression, immune infiltration and clinical significance of SPAG5 in hepatocellular carcinoma: A gene expression-based study. | Expression, immune infiltration and clinical significance of SPAG5 in hepatocellular carcinoma: A gene expression-based study.
Chen W, Chen X, Li S, Ren B. | 07/17/2021 |
| Investigation of the SPAG5 gene expression and amplification related to the NuMA mRNA levels in breast ductal carcinoma. | Investigation of the SPAG5 gene expression and amplification related to the NuMA mRNA levels in breast ductal carcinoma.
Mohamadalizadeh-Hanjani Z, Shahbazi S, Geranpayeh L., Free PMC Article | 07/10/2021 |
| Micro RNA-363 inhibits esophageal squamous cell carcinoma progression by directly targeting sperm-associated antigen 5. | Micro RNA-363 inhibits esophageal squamous cell carcinoma progression by directly targeting sperm-associated antigen 5.
Zhang L, Wang L, Lu N, Wang J, Yan R, Yan H, Zhang J, Zhang M., Free PMC Article | 06/26/2021 |
| SPAG5: An Emerging Oncogene. | SPAG5: An Emerging Oncogene.
He J, Green AR, Li Y, Chan SYT, Liu DX. | 06/12/2021 |
| SPAG5 promotes osteosarcoma metastasis via activation of FOXM1/MMP2 axis. | SPAG5 promotes osteosarcoma metastasis via activation of FOXM1/MMP2 axis.
Li Z, Li H, Chen J, Luo H, Zeng J, Yao Y, Duan M. | 05/8/2021 |
| High expression of sperm-associated antigen 5 correlates with poor survival in ovarian cancer. | High expression of sperm-associated antigen 5 correlates with poor survival in ovarian cancer.
Zhang M, Sha L, Hou N, Shi C, Tan L., Free PMC Article | 03/20/2021 |
| High expression of SPAG5 sustains the malignant growth and invasion of breast cancer cells through the activation of Wnt/beta-catenin signalling | High expression of SPAG5 sustains the malignant growth and invasion of breast cancer cells through the activation of Wnt/β-catenin signalling.
Jiang J, Wang J, He X, Ma W, Sun L, Zhou Q, Li M, Yu S. | 07/4/2020 |
| SPAG5 promotes the progression of GC via enhancing the Wnt/beta-catenin/Survivin axis. | SPAG5 contributes to the progression of gastric cancer by upregulation of Survivin depend on activating the wnt/β-catenin pathway.
Liu G, Liu S, Cao G, Luo W, Li P, Wang S, Chen Y. | 05/30/2020 |
| SPAG5 is upregulated in lung adenocarcinoma. SPAG5 knockdown suppresses proliferation, colony forming, and migration. SPAG5 is regulated in a p53-and p21-dependent manner. | p53 suppression is essential for oncogenic SPAG5 upregulation in lung adenocarcinoma.
Wang T, Li K, Song H, Xu D, Liao Y, Jing B, Guo W, Hu M, Kuang Y, Sun B, Ling J, Zhang T, Xu J, Yao F, Deng J. | 05/2/2020 |
| SPAG5 could be used as an independent prognostic and predictive biomarker that might have clinical utility, especially in ER+ breast cancer patients who received hormonal therapy | The prognostic association of SPAG5 gene expression in breast cancer patients with systematic therapy.
Zhu C, Menyhart O, Győrffy B, He X., Free PMC Article | 04/4/2020 |
| SPAG5 was upregulated in triple-negative breast cancer tissues and that high SPAG5 expression was associated with high risk of local recurrence and poorer outcomes in triple-negative breast cancer patients. SPAG5 functioned as an oncogenic gene in triple-negative breast cancer by interacting with MYCBP and increasing c-MYC transcriptional activity. | SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer.
Li M, Li A, Zhou S, Lv H, Yang W., Free PMC Article | 03/14/2020 |
| SPAG5-AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway. | SPAG5-AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway.
Xu J, Deng Y, Wang Y, Sun X, Chen S, Fu G., Free PMC Article | 03/7/2020 |
| miR-1179 inhibits the growth and invasion of non-small cell lung cancer cells by targeting SPAG5 and inhibiting Akt | MicroRNA-1179 suppresses cell growth and invasion by targeting sperm-associated antigen 5-mediated Akt signaling in human non-small cell lung cancer.
Song L, Dai Z, Zhang S, Zhang H, Liu C, Ma X, Liu D, Zan Y, Yin X. | 03/30/2019 |
| Data show that increased expression of SPAG5 in hepatocellular carcinoma (HCC) was closely correlated with poor outcomes, indicating that SPAG5 serves a promising prognostic factor in HCC, and functions as an oncogene via CEP55-mediated PI3K/AKT pathway. | SPAG5 interacts with CEP55 and exerts oncogenic activities via PI3K/AKT pathway in hepatocellular carcinoma.
Yang YF, Zhang MF, Tian QH, Fu J, Yang X, Zhang CZ, Yang H., Free PMC Article | 03/23/2019 |
| The importance of the SPAG5/AKT-mTOR/Wnt3 axis identified in BUC cell models. | SPAG5 promotes proliferation and suppresses apoptosis in bladder urothelial carcinoma by upregulating Wnt3 via activating the AKT/mTOR pathway and predicts poorer survival.
Liu JY, Zeng QH, Cao PG, Xie D, Yang F, He LY, Dai YB, Li JJ, Liu XM, Zeng HL, Fan XJ, Liu L, Zhu YX, Gong L, Cheng Y, Zhou JD, Hu J, Bo H, Xu ZZ, Cao K. | 03/2/2019 |
| we report the differential SPAG5 expression at both the protein and mRNA levels in Hepatocellular Carcinoma. SPAG5 may be considered a new prognostic marker for Hepatocellular Carcinoma patients, and targeting SPAG5 could provide new treatment strategies for Hepatocellular Carcinoma. | Sperm-Associated Antigen 5 Expression Is Increased in Hepatocellular Carcinoma and Indicates Poor Prognosis.
Zhou H, Wang SC, Ma JM, Yu LQ, Jing JS., Free PMC Article | 12/22/2018 |
| our data provide a novel evidence for the biological and clinical significance of SPAG5 as a potential biomarker, and we demonstrate that SPAG5-b-catenin-SCARA5 might be a novel pathway involved in hepatocellular carcinoma progression. | SPAG5 promotes hepatocellular carcinoma progression by downregulating SCARA5 through modifying β-catenin degradation.
Liu H, Hu J, Wei R, Zhou L, Pan H, Zhu H, Huang M, Luo J, Xu W., Free PMC Article | 11/10/2018 |