| Rapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy. | Rapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy.
Walker FM, Sobral LM, Danis E, Sanford B, Donthula S, Balakrishnan I, Wang D, Pierce A, Karam SD, Kargar S, Serkova NJ, Foreman NK, Venkataraman S, Dowell R, Vibhakar R, Dahl NA., Free PMC Article | 09/20/2024 |
| HEXIM1 is an essential transcription regulator during human erythropoiesis. | HEXIM1 is an essential transcription regulator during human erythropoiesis.
Lv X, Murphy K, Murphy Z, Getman M, Rahman N, Nakamura Y, Blanc L, Gallagher PG, Palis J, Mohandas N, Steiner LA., | 12/23/2023 |
| UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat. | UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat.
Liang T, Zhang Q, Wu Z, Chen P, Huang Y, Liu S, Li L., Free PMC Article | 01/8/2022 |
| Downregulation of Dihydrotestosterone and Estradiol Levels by HEXIM1. | Downregulation of Dihydrotestosterone and Estradiol Levels by HEXIM1.
Mozar F, Sharma V, Gorityala S, Albert JM, Xu Y, Montano MM., Free PMC Article | 01/1/2022 |
| HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer. | HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer.
Shao H, Zhu Q, Lu H, Chang A, Gao C, Zhou Q, Luo K., Free PMC Article | 06/12/2021 |
| Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer. | Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer.
Yeh IJ, Esakov E, Lathia JD, Miyagi M, Reizes O, Montano MM., Free PMC Article | 11/28/2020 |
| HEXIM1 Diffusion in the Nucleus Is Regulated by Its Interactions with Both 7SK and P-TEFb. | HEXIM1 Diffusion in the Nucleus Is Regulated by Its Interactions with Both 7SK and P-TEFb.
Furlan A, Gonzalez-Pisfil M, Leray A, Champelovier D, Henry M, Le Nézet C, Bensaude O, Lefranc M, Wohland T, Vandenbunder B, Bidaux G, Héliot L., Free PMC Article | 09/26/2020 |
| HMBA and 4a1 induce HEXIM1 expression by inhibiting KDM5B. Upregulation of HEXIM1 expression levels plays a critical role in the inhibition of proliferation of breast cancer cells using KDM5B inhibitors. | Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.
Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC., Free PMC Article | 05/23/2020 |
| Structural transitions in the RNA 7SK 5' hairpin and their effect on HEXIM binding have been reported. | Structural transitions in the RNA 7SK 5' hairpin and their effect on HEXIM binding.
Röder K, Stirnemann G, Dock-Bregeon AC, Wales DJ, Pasquali S., Free PMC Article | 03/21/2020 |
| Both HEXIM1 and RAD51 promote BET inhibitor-induced fork slowing but also prevent a DNA damage response. | BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication.
Bowry A, Piberger AL, Rojas P, Saponaro M, Petermann E., Free PMC Article | 12/14/2019 |
| The 7SK RNA binds to Hexim1 and turns it into an inhibitor of the positive transcription elongation factor (P-TEFb). And in addition to its action on P-TEFb, it plays a role in a variety of different mechanisms: it controls the stability of transcription factor components and assists binding of transcription factors to their targets. | Hexim1, an RNA-controlled protein hub.
Michels AA, Bensaude O., Free PMC Article | 10/27/2018 |
| We conclude that the degradation of NPM1 and HEXIM1 through autophagy in certain AML subsets contributes to the activation of the BET pathway in these cells. | Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells.
Huang M, Garcia JS, Thomas D, Zhu L, Nguyen LX, Chan SM, Majeti R, Medeiros BC, Mitchell BS., Free PMC Article | 03/3/2018 |
| Identify a HEXIM1-containing ribonuclear protein complex composed also of DNA-PK, paraspeckle subunits, and the long non-coding RNA (lncRNA) NEAT1, which acts as a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway. | HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D, Dubois E, Schwartz O, Bennasser Y, Benkirane M. | 09/30/2017 |
| HMBA and derivative HMBA4a1 induce HEXIM1 activity, targeting several signaling pathways critical in tumorigenesis and metastasis. | Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism.
Ketchart W, Yeh IJ, Zhou H, Thiagarajan PS, Lathia J, Reizes O, Exner A, Su B, Montano MM., Free PMC Article | 07/29/2017 |
| HSP70 activator shows similar activity as HMBA and 4a1 to induce HEXIM1 expression, suggesting that HMBA and 4a1 might be putative HSP70 activators | HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen.
Lama R, Gan C, Idippily N, Bobba V, Danielpour D, Montano M, Su B., Free PMC Article | 07/8/2017 |
| Our results demonstrated that HEXIM1 exhibited the most consistent response to BET inhibitors in all of the settings examined, including tumors and surrogate tissues. | HEXIM1 as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues.
Lin X, Huang X, Uziel T, Hessler P, Albert DH, Roberts-Rapp LA, McDaniel KF, Kati WM, Shen Y. | 07/1/2017 |
| Suggest that greater tumor associated macrophage density, strong Hexim1 expression, strong SMAD2 expression, and mild SMAD7 expression play important roles in the progression of prostate adenocarcinoma. | Role of tumor-associated macrophages in the Hexim1 and TGFβ/SMAD pathway, and their influence on progression of prostatic adenocarcinoma.
Ok Atılgan A, Özdemir BH, Akçay EY, Ataol Demirkan Ö, Tekindal MA, Özkardeş H. | 11/12/2016 |
| Results show that HEXIM1 is a tumor suppressor in melanoma that responds to nucleotide stress by inhibiting transcription elongation of tumorigenic genes and stabilizing mRNA transcripts of other tumor suppressor genes. | Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.
Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI., Free PMC Article | 09/3/2016 |
| Data indicate the binding of RNA-binding protein HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE and LARP7. | Intermolecular recognition of the non-coding RNA 7SK and HEXIM protein in perspective.
Martinez-Zapien D, Saliou JM, Han X, Atmanene C, Proux F, Cianférani S, Dock-Bregeon AC. | 06/28/2016 |
| PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP. | PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.
Gudipaty SA, McNamara RP, Morton EL, D'Orso I., Free PMC Article | 02/6/2016 |
| This study demonstrates a novel role of HEXIM1 in regulating human pluripotent stem cells fate through a P-TEFb-independent pathway. | HEXIM1 induces differentiation of human pluripotent stem cells.
Ding V, Lew QJ, Chu KL, Natarajan S, Rajasegaran V, Gurumurthy M, Choo AB, Chao SH., Free PMC Article | 01/17/2015 |
| HEXIM1 functions as an AR (androgen receptor) co-repressor as it physically interacts with the AR and is required for the ability of anti-androgens to inhibit androgen-induced target gene expression and cell proliferation. | HEXIM1 plays a critical role in the inhibition of the androgen receptor by anti-androgens.
Yeh IJ, Song K, Wittmann BM, Bai X, Danielpour D, Montano MM., Free PMC Article | 10/25/2014 |
| the release of P-TEFb from the 7SK snRNP led to increased synthesis of HEXIM1 but not HEXIM2 | Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.
Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM., Free PMC Article | 05/31/2014 |
| There is evidence for a direct interaction between HIF-1alpha and HEXIM1, and HEXIM1 up-regulated hydroxylation of HIF-1alpha. | HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability.
Yeh IJ, Ogba N, Bensigner H, Welford SM, Montano MM., Free PMC Article | 01/11/2014 |
| P-TEFb/HEXIM1-dependent transcriptional regulation may play a pathophysiological role in RVH and be a novel therapeutic target for mitigating RVH in PAH | Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.
Yoshikawa N, Shimizu N, Maruyama T, Sano M, Matsuhashi T, Fukuda K, Kataoka M, Satoh T, Ojima H, Sawai T, Morimoto C, Kuribara A, Hosono O, Tanaka H., Free PMC Article | 07/6/2013 |