| O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression. | O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression.
Zhao J, Hua J, Zhan Y, Chen C, Liu Y, Yang L, Wang H, Wang H, Li J., Free PMC Article | 05/24/2024 |
| LncRNA MNX1-AS1 sustains inactivation of Hippo pathway through a positive feedback loop with USP16/IGF2BP3 axis in gallbladder cancer. | LncRNA MNX1-AS1 sustains inactivation of Hippo pathway through a positive feedback loop with USP16/IGF2BP3 axis in gallbladder cancer.
Liu S, Li H, Zhu Y, Ma X, Shao Z, Yang Z, Cai C, Wu Z, Li M, Gong W, Wu X. | 09/24/2022 |
| USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc. | USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc.
Ge J, Yu W, Li J, Ma H, Wang P, Zhou Y, Wang Y, Zhang J, Shi G., Free PMC Article | 10/16/2021 |
| USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit. | USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit.
Montellese C, van den Heuvel J, Ashiono C, Dörner K, Melnik A, Jonas S, Zemp I, Picotti P, Gillet LC, Kutay U., Free PMC Article | 05/8/2021 |
| USP16 Regulates the Stability and Function of LDL receptor by Deubiquitination. | USP16 Regulates the Stability and Function of LDL receptor by Deubiquitination.
Li Y, Rao Y, Zhu H, Jiang B, Zhu M. | 10/24/2020 |
| USP16 gene expression is tightly regulated at transcription level. | Transcriptional activation of USP16 gene expression by NFκB signaling.
Yang S, Wang J, Guo S, Huang D, Lorigados IB, Nie X, Lou D, Li Y, Liu M, Kang Y, Zhou W, Song W., Free PMC Article | 07/11/2020 |
| data reveal the physiological function of CNA ubiquitination and its deubiquitinase USP16 in peripheral T cells. | USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance.
Zhang Y, Liu RB, Cao Q, Fan KQ, Huang LJ, Yu JS, Gao ZJ, Huang T, Zhong JY, Mao XT, Wang F, Xiao P, Zhao Y, Feng XH, Li YY, Jin J., Free PMC Article | 05/23/2020 |
| USP16 was frequently downregulated. | USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells.
Qian Y, Wang B, Ma A, Zhang L, Xu G, Ding Q, Jing T, Wu L, Liu Y, Yang Z, Liu Y., Free PMC Article | 05/26/2018 |
| USP16 and TTC3 were dysregulated in all affected human cells and two mouse models of Down syndrome. | An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.
Guedj F, Pennings JL, Massingham LJ, Wick HC, Siegel AE, Tantravahi U, Bianchi DW., Free PMC Article | 05/19/2018 |
| The data unveil a unique mechanism by which Usp16 promotes the localization and maintenance of Plk1 on the kinetochores for proper chromosome alignment. | Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis.
Zhuo X, Guo X, Zhang X, Jing G, Wang Y, Chen Q, Jiang Q, Liu J, Zhang C., Free PMC Article | 12/19/2015 |
| Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal. | The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage.
Zhang Z, Yang H, Wang H., Free PMC Article | 02/14/2015 |
| S552P disrupts the interaction between Ubp-M and nuclear export protein CRM1, increasing Ubp-M nuclear retention as cells progress into M phase, revealing a critical function for Ubp-M S552P. | Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression.
Xu Y, Yang H, Joo HY, Yu JH, Smith AD 4th, Schneider D, Chow LT, Renfrow M, Wang H., Free PMC Article | 04/19/2014 |
| in human tissues overexpression of USP16 reduces the expansion of normal fibroblasts and postnatal neural progenitors, whereas downregulation of USP16 partially rescues the proliferation defects of Down's syndrome fibroblasts | Usp16 contributes to somatic stem-cell defects in Down's syndrome.
Adorno M, Sikandar S, Mitra SS, Kuo A, Nicolis Di Robilant B, Haro-Acosta V, Ouadah Y, Quarta M, Rodriguez J, Qian D, Reddy VM, Cheshier S, Garner CC, Clarke MF., Free PMC Article | 11/16/2013 |
| a new cryptic USP16-RUNX1 fusion in chronic myelomonocytic leukemia | Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.
Gelsi-Boyer V, Trouplin V, Adélaïde J, Aceto N, Remy V, Pinson S, Houdayer C, Arnoulet C, Sainty D, Bentires-Alj M, Olschwang S, Vey N, Mozziconacci MJ, Birnbaum D, Chaffanet M., Free PMC Article | 01/21/2010 |
| knockdown of Ubp-M in HeLa cells results in slow cell growth rates owing to defects in the mitotic phase of the cell cycle | Regulation of cell cycle progression and gene expression by H2A deubiquitination.
Joo HY, Zhai L, Yang C, Nie S, Erdjument-Bromage H, Tempst P, Chang C, Wang H. | 01/21/2010 |
| Study reports the solution structure of the BUZ domain of Ubp-M, a ubiquitin-specific protease, and its interaction with ubiquitin; the Ubp-M BUZ domain features three zinc-binding sites consisting of 12 residues. | Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.
Pai MT, Tzeng SR, Kovacs JJ, Keaton MA, Li SS, Yao TP, Zhou P., Free PMC Article | 01/21/2010 |