| SCGN deficiency is a risk factor for autism spectrum disorder. | SCGN deficiency is a risk factor for autism spectrum disorder.
Liu Z, Tan S, Zhou L, Chen L, Liu M, Wang W, Tang Y, Yang Q, Chi S, Jiang P, Zhang Y, Cui Y, Qin J, Hu X, Li S, Liu Q, Chen L, Li S, Burstein E, Li W, Zhang X, Mo X, Jia D., Free PMC Article | 01/11/2023 |
| Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice. | Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice.
Tapia-González S, Insausti R, DeFelipe J., Free PMC Article | 07/31/2021 |
| In this study, the authors report the identification of an ultrarare missense variant (NM_006998.3:c.230G > A;p.Arg77His) in the SCGN gene causing Mendelian early-onset ulcerative colitis. | SCGN deficiency results in colitis susceptibility.
Sifuentes-Dominguez LF, Li H, Llano E, Liu Z, Singla A, Patel AS, Kathania M, Khoury A, Norris N, Rios JJ, Starokadomskyy P, Park JY, Gopal P, Liu Q, Tan S, Chan L, Ross T, Harrison S, Venuprasad K, Baker LA, Jia D, Burstein E., Free PMC Article | 03/14/2020 |
| the overexpression of SCGN in SW480 human colorectal cancer cells promoted cell apoptosis and inhibited cell migration and invasion. | Overexpression of secretagogin promotes cell apoptosis and inhibits migration and invasion of human SW480 human colorectal cancer cells.
Yang XY, Liu QR, Wu LM, Zheng XL, Ma C, Na RS. | 09/15/2018 |
| Glucose-dependent de-SUMOylation of tomosyn1 at K298 releases syntaxin1A and controls the amplification of exocytosis in concert with a recently-identified tomosyn1-interacting partner; the Ca(2+)-binding protein secretagogin, which dissociates from tomosyn1 in response to Ca(2+)-raising stimuli and is required for insulin granule trafficking and exocytosis downstream of Ca(2+) influx. | SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.
Ferdaoussi M, Fu J, Dai X, Manning Fox JE, Suzuki K, Smith N, Plummer G, MacDonald PE., Free PMC Article | 09/1/2018 |
| secretagogin is a potential biomarker, reflecting stress and islet cell dysfunction in T2D patients | Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction.
Hansson SF, Zhou AX, Vachet P, Eriksson JW, Pereira MJ, Skrtic S, Jongsma Wallin H, Ericsson-Dahlstrand A, Karlsson D, Ahnmark A, Sörhede Winzell M, Magnone MC, Davidsson P., Free PMC Article | 08/4/2018 |
| Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration. | Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.
Hanics J, Szodorai E, Tortoriello G, Malenczyk K, Keimpema E, Lubec G, Hevesi Z, Lutz MI, Kozsurek M, Puskár Z, Tóth ZE, Wagner L, Kovács GG, Hökfelt TG, Harkany T, Alpár A., Free PMC Article | 04/14/2018 |
| The low SCGN plasma levels in children with ASD probably indicate that SCGN might be implicated in the pathogenesis of autism. However, these data should be treated with caution until further investigations are performed using larger sample sizes to determine whether the decrease in plasma SCGN levels is a mere consequence of autism or it plays a pathogenic role in the disease. | Secretagogin (SCGN) Plasma Levels and their Association with Cognitive and Social Behavior in Children with Autism Spectrum Disorder ASD).
Alhowikan AM, -Ayadhi LA, Halepoto DM. | 01/20/2018 |
| Therefore, and considering the desensitization of TRPV1s in diabetic pancreata, a TRPV1-to-secretagogin regulatory axis seems critical to maintain the structural integrity and signal competence of beta-cells. | A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.
Malenczyk K, Girach F, Szodorai E, Storm P, Segerstolpe Å, Tortoriello G, Schnell R, Mulder J, Romanov RA, Borók E, Piscitelli F, Di Marzo V, Szabó G, Sandberg R, Kubicek S, Lubec G, Hökfelt T, Wagner L, Groop L, Harkany T., Free PMC Article | 07/29/2017 |
| These results suggest SCGN is involved in the chemoresistance of small cell lung cancer under the regulation of miR-494 | Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494.
Bai Y, Sun Y, Peng J, Liao H, Gao H, Guo Y, Guo L., Free PMC Article | 08/8/2015 |
| Scgn is a CaBP expressed in a subpopulation of nociceptive DRG neurons and their processes in the dorsal horn. | Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human.
Shi TJ, Xiang Q, Zhang MD, Tortoriello G, Hammarberg H, Mulder J, Fried K, Wagner L, Josephson A, Uhlén M, Harkany T, Hökfelt T., Free PMC Article | 06/8/2013 |
| While secretagogin mRNA was detected in both peripheral mononuclear cells and erythrocytes using reverse-transcription polymerase chain reaction, SCGN protein was only detected in erythrocytes. | Detectability of secretagogin in human erythrocytes.
Tan WS, Lee JJ, Satish RL, Ang ET. | 12/22/2012 |
| Data show that the density of secretagogin-positive neurons selectively decreases in the olfactory tract in Alzheimer's disease. | Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.
Attems J, Alpar A, Spence L, McParland S, Heikenwalder M, Uhlén M, Tanila H, Hökfelt TG, Harkany T., Free PMC Article | 07/14/2012 |
| Levels of secretagogin correlate with mortality and are useful as predictors of outcome in children with traumatic brain injury. | The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury.
Žurek J, Fedora M. | 06/30/2012 |
| Ddetection of novel calcium-binding protein secretagogin within subgroup of clear-cell renal cell carcinomas. Increased metastasis rates within secretagogin-positive subgroup of clear-cell renal cell carcinomas. | Expression of secretagogin in clear-cell renal cell carcinomas is associated with a high metastasis rate.
Ilhan A, Neziri D, Maj M, Mazal PR, Susani M, Base W, Gartner W, Wagner L. | 06/18/2011 |
| Results emphasize the developmentally shared origins of neurons populating the extended amygdala, and suggest that secretagogin can be relevant to the generation of functional modalities in specific neuronal circuitries. | Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon.
Mulder J, Spence L, Tortoriello G, Dinieri JA, Uhlén M, Shui B, Kotlikoff MI, Yanagawa Y, Aujard F, Hökfelt T, Hurd YL, Harkany T., Free PMC Article | 01/29/2011 |
| Secretagogin might play a role in human non-functional pituitary adenomas. This novel finding may provide clues to clarify the basic molecular mechanisms of pituitary adenoma formation, and to identify new tumor-related markers. | Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas.
Zhan X, Evans CO, Oyesiku NM, Desiderio DM. | 01/21/2010 |
| two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin | Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene.
Zierhut B, Daneva T, Gartner W, Brunnmaier B, Mineva I, Berggård T, Wagner L. | 01/21/2010 |
| We identified and characterized promoter activity of a human 1498 bp secretagogin sequence upstream the transcription start site. | Identification and characterization of secretagogin promoter activity.
Skovhus KV, Bergholdt R, Erichsen C, Sparre T, Nerup J, Karlsen AE, Pociot F. | 01/21/2010 |