| Association analysis of variants rs35934224 in TXNRD2 and rs6478746 in LMX1B in primary angle-closure and pseudoexfoliation glaucoma. | Association analysis of variants rs35934224 in TXNRD2 and rs6478746 in LMX1B in primary angle-closure and pseudoexfoliation glaucoma.
Kondkar AA, Sultan T, Alobaidan AS, Azad TA, Osman EA, Almobarak FA, Lobo GP, Al-Obeidan SA. | 07/23/2022 |
| TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondenceReply to ""TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondence""Primary open-angle glaucomaGenome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucomaGenome-wide association study of primary open-angle glaucoma in continental and admixed African popula... | TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondenceReply to "TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondence"Primary open-angle glaucomaGenome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucomaGenome-wide association study of primary open-angle glaucoma in continental and admixed African populations.
Sookaromdee P, Wiwanitkit V. | 07/23/2022 |
| TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population. | TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population.
Tenório AL, Lira RPC, Carmo RFD, Galvão Filho RP, Falcão Neto PT, Vaz RT, Lima RE, Tenório AL, Vasconcelos LR. | 04/23/2022 |
| miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2. | miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2.
Bu L, Tian Y, Wen H, Jia W, Yang S. | 06/12/2021 |
| The aim of the study was to investigate the association between rs5859 in Sep15, rs1139793 in TrxR2 polymorphisms with the risks of KBD and to detect the expression of AP-1 pathway. | The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease.
Wu R, Zhang R, Xiong Y, Sun W, Li Y, Yang X, Liu J, Jiang Y, Guo H, Mo X, Cao J. | 02/22/2020 |
| Based on recent research, it has been reported that the modulation of the Trx/TrxR system may be considered as a new target in the management of the metabolic syndrome, insulin resistance, and type 2 diabetes, as well as in the treatment of hypertension and atherosclerosis. In this review evidence about a possible role of this system as a marker of the metabolic syndrome is reported. [review] | The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?
Tinkov AA, Bjørklund G, Skalny AV, Holmgren A, Skalnaya MG, Chirumbolo S, Aaseth J., Free PMC Article | 10/27/2018 |
| TrxR2 was overexpressed in non-small-cell lung cancer cells; our results suggest that TrxR2 acts as an oncogenic gene in the context of lung cancer progression | Inhibition of TrxR2 suppressed NSCLC cell proliferation, metabolism and induced cell apoptosis through decreasing antioxidant activity.
Bu L, Li W, Ming Z, Shi J, Fang P, Yang S. | 07/1/2017 |
| p53R2 acts as a positive regulator of TrxR2 activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage | p53R2 regulates thioredoxin reductase activity through interaction with TrxR2.
Park SJ, Kim HB, Piao C, Kang MY, Park SG, Kim SW, Lee JH. | 06/10/2017 |
| TrxR2 deficiency-induced impaired proliferation and death of chondrocytes may be the pathological mechanism of the osteoarthropathy due to Selenium deficiency. | TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species.
Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, Lu S. | 05/13/2017 |
| Evidence that the rs4485648 polymorphism of the TrxR2 gene might exert an independent effect on the development of Diabetic retinopathy. | Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
Ramus SM, Cilensek I, Petrovic MG, Soucek M, Kruzliak P, Petrovic D. | 12/17/2016 |
| Data suggest that TXNRD2 may represent a druggable target that could be deployed to reduce the development of fatal pulmonary metastases in patients with osteosarcoma (OS). | Auranofin is a potent suppressor of osteosarcoma metastasis.
Topkas E, Cai N, Cumming A, Hazar-Rethinam M, Gannon OM, Burgess M, Saunders NA, Endo-Munoz L., Free PMC Article | 11/12/2016 |
| A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2, ATXN2, and FOXC1 | Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.
Bailey JN, Loomis SJ, Kang JH, Allingham RR, Gharahkhani P, Khor CC, Burdon KP, Aschard H, Chasman DI, Igo RP Jr, Hysi PG, Glastonbury CA, Ashley-Koch A, Brilliant M, Brown AA, Budenz DL, Buil A, Cheng CY, Choi H, Christen WG, Curhan G, De Vivo I, Fingert JH, Foster PJ, Fuchs C, Gaasterland D, Gaasterland T, Hewitt AW, Hu F, Hunter DJ, Khawaja AP, Lee RK, Li Z, Lichter PR, Mackey DA, McGuffin P, Mitchell P, Moroi SE, Perera SA, Pepper KW, Qi Q, Realini T, Richards JE, Ridker PM, Rimm E, Ritch R, Ritchie M, Schuman JS, Scott WK, Singh K, Sit AJ, Song YE, Tamimi RM, Topouzis F, Viswanathan AC, Verma SS, Vollrath D, Wang JJ, Weisschuh N, Wissinger B, Wollstein G, Wong TY, Yaspan BL, Zack DJ, Zhang K, Study EN, ANZRAG Consortium, Weinreb RN, Pericak-Vance MA, Small K, Hammond CJ, Aung T, Liu Y, Vithana EN, MacGregor S, Craig JE, Kraft P, Howell G, Hauser MA, Pasquale LR, Haines JL, Wiggs JL., Free PMC Article | 06/4/2016 |
| The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for Myocardial infarction in subjects with T2 Diabetes mellitus of Slovenian origin. | Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus.
Kariž S, Mankoč S, Petrovič D. | 12/12/2015 |
| Data suggest TXNRD1 and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults. | Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine.
Cunniff B, Snider GW, Fredette N, Stumpff J, Hondal RJ, Heintz NH., Free PMC Article | 06/20/2015 |
| Absence of TXNRD2 in humans leads to glucocorticoid deficiency. | Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).
Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA., Free PMC Article | 11/8/2014 |
| Single Nucleotide Polymorphisms in the genes GPX1 (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population. | Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population.
Huang L, Shi Y, Lu F, Zheng H, Liu X, Gong B, Yang J, Lin Y, Cheng J, Ma S, Lin H, Yang Z., Free PMC Article | 06/28/2014 |
| Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS, and maintenance of the intracellular redox balance. | SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling.
Edvardsen H, Landmark-Høyvik H, Reinertsen KV, Zhao X, Grenaker-Alnæs GI, Nebdal D, Syvänen AC, Rødningen O, Alsner J, Overgaard J, Borresen-Dale AL, Fosså SD, Kristensen VN. | 08/31/2013 |
| Data suggest that dietary factor (selenium supplementation) up-regulates endogenous antioxidant systems and protects trophoblasts from oxidative stress; selenium upregulates GPX1 (glutathione peroxidase 1) and thioredoxin reductases (TXNRD1; TXNRD2). | Selenium supplementation protects trophoblast cells from oxidative stress.
Watson M, van Leer L, Vanderlelie JJ, Perkins AV. | 05/4/2013 |
| A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development. | The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium.
Kipp AP, Müller MF, Göken EM, Deubel S, Brigelius-Flohé R. | 03/16/2013 |
| No obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to Kashin-Beck disease. | [TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease].
Lu W, Mo XY, Xiong YM. | 02/16/2013 |
| Mutation of this gene is involved in regulation of cellular redoc state in Dilated Cardiomyopathy. | Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.
Sibbing D, Pfeufer A, Perisic T, Mannes AM, Fritz-Wolf K, Unwin S, Sinner MF, Gieger C, Gloeckner CJ, Wichmann HE, Kremmer E, Schäfer Z, Walch A, Hinterseer M, Näbauer M, Kääb S, Kastrati A, Schömig A, Meitinger T, Bornkamm GW, Conrad M, von Beckerath N. | 01/7/2012 |
| study reveals significant differences between TrxR1 and TrxR2 in substrate specificity and metal compound inhibition in vitro and in cells | Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors.
Rackham O, Shearwood AM, Thyer R, McNamara E, Davies SM, Callus BA, Miranda-Vizuete A, Berners-Price SJ, Cheng Q, Arnér ES, Filipovska A. | 08/20/2011 |
| Observations underpin a likely critical antioxidant role for TrxR2 and TrxR1 in the endothelium. | Modulation of thioredoxin reductase-2 expression in EAhy926 cells: implications for endothelial selenoprotein hierarchy.
Crane MS, Howie AF, Arthur JR, Nicol F, Crosley LK, Beckett GJ. | 01/21/2010 |
| Over-expression of TXNRD2, COMT and ARVCF affects incentive learning and working memory in transgenic mice. | Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice.
Suzuki G, Harper KM, Hiramoto T, Funke B, Lee M, Kang G, Buell M, Geyer MA, Kucherlapati R, Morrow B, Männistö PT, Agatsuma S, Hiroi N., Free PMC Article | 01/21/2010 |
| The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer. | [Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer].
Wang J, Sun T, Yang M, Lin DX, Tan W, Li KJ, Xiao Y. | 01/21/2010 |