| Unveiling the immunoregulatory role of interferon-induced transmembrane protein 2 through the JAK/STAT3/PDL1 pathway in gastric cancer. | Unveiling the immunoregulatory role of interferon-induced transmembrane protein 2 through the JAK/STAT3/PDL1 pathway in gastric cancer.
Liu Y, Liang J, Huang J, Li X, Huang J, Wang J. | 10/19/2024 |
| IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway. | IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.
Chen L, Li X, Deng Y, Bi Y, Yan Z, Yang Y, Zhang X, Li H, Xie J, Feng R., Free PMC Article | 05/3/2023 |
| SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells. | SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells.
Nchioua R, Schundner A, Kmiec D, Prelli Bozzo C, Zech F, Koepke L, Graf A, Krebs S, Blum H, Frick M, Sparrer KMJ, Kirchhoff F., Free PMC Article | 06/18/2022 |
| Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner. | Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner.
Hörnich BF, Großkopf AK, Dcosta CJ, Schlagowski S, Hahn AS., Free PMC Article | 02/26/2022 |
| IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication. | IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication.
Meischel T, Fritzlar S, Villalon-Letelier F, Tessema MB, Brooks AG, Reading PC, Londrigan SL., Free PMC Article | 10/23/2021 |
| IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro. | IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Rodríguez Alfonso AA, Wiese S, Sauter D, Münch J, Goffinet C, Catanese A, Schön M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F., Free PMC Article | 08/7/2021 |
| Predicative value of IFITM2 in renal clear cell carcinoma: IFITM2 is associated with lymphatic metastasis and poor clinical outcome. | Predicative value of IFITM2 in renal clear cell carcinoma: IFITM2 is associated with lymphatic metastasis and poor clinical outcome.
Yang N, Liu Z, Pang S, Wu J, Liang J, Sun L. | 04/13/2021 |
| Opposing activities of IFITM proteins in SARS-CoV-2 infection. | Opposing activities of IFITM proteins in SARS-CoV-2 infection.
Shi G, Kenney AD, Kudryashova E, Zani A, Zhang L, Lai KK, Hall-Stoodley L, Robinson RT, Kudryashov DS, Compton AA, Yount JS., Free PMC Article | 02/6/2021 |
| IFITM1-IFITM3 are expressed by T cells and are directly involved in adaptive immunity; they regulate CD4+ T helper cell differentiation in a T-cell-intrinsic manner. (Review) | The IFITM protein family in adaptive immunity.
Yánez DC, Ross S, Crompton T., Free PMC Article | 08/1/2020 |
| IFITM2 knockdowns in BeWo trophoblasts increased their spontaneous fusion and allowed fusion in the presence of IFN while also making the cells more susceptible to virus infection. | Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins.
Zani A, Zhang L, McMichael TM, Kenney AD, Chemudupati M, Kwiek JJ, Liu SL, Yount JS., Free PMC Article | 06/27/2020 |
| These studies identify a novel role for IFITM1, 2, and 3 in inhibiting HIV replication at the level of translation. | IFITM proteins inhibit HIV-1 protein synthesis.
Lee WJ, Fu RM, Liang C, Sloan RD., Free PMC Article | 11/16/2019 |
| overexpression of IFITM1, 2 and 3 suppressed entry of CXCR4 and CCR5 tropic viruses; entry of transmitted founder HIV-1 in U87 cells is more sensitive to inhibition by IFITM2 and IFITM3 than by IFITM1 | The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage.
Yu J, Liu SL., Free PMC Article | 03/16/2019 |
| Delta20 IFITM2 may serve as a major contributor to the gatekeeping mechanism that explains restriction of X4 viruses in the early stage of HIV-1 infection | Δ20 IFITM2 differentially restricts X4 and R5 HIV-1.
Wu WL, Grotefend CR, Tsai MT, Wang YL, Radic V, Eoh H, Huang IC., Free PMC Article | 06/16/2018 |
| These results indicate that IFITM2 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes. | Alphavirus Restriction by IFITM Proteins.
Weston S, Czieso S, White IJ, Smith SE, Wash RS, Diaz-Soria C, Kellam P, Marsh M., Free PMC Article | 10/28/2017 |
| The transcriptional regulation of IFITM1, 2 and 3 expression. | Coordinated regulation of IFITM1, 2 and 3 genes by an IFN-responsive enhancer through long-range chromatin interactions.
Li P, Shi ML, Shen WL, Zhang Z, Xie DJ, Zhang XY, He C, Zhang Y, Zhao ZH., Free PMC Article | 10/28/2017 |
| IFITM2 promotes gastric cancer growth and metastasis via IGF1/IGF1R/STAT3 signaling pathway. | IGF1/IGF1R/STAT3 signaling-inducible IFITM2 promotes gastric cancer growth and metastasis.
Xu L, Zhou R, Yuan L, Wang S, Li X, Ma H, Zhou M, Pan C, Zhang J, Huang N, Shi M, Bin J, Liao Y, Liao W. | 08/19/2017 |
| findings show that the sensitivity of influenza A viruses to the IFN-induced antiviral state and IFITM2 and IFITM3 proteins depends on the pH value at which the viral HA undergoes a conformational transition and mediates membrane fusion | pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.
Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, Klenk HD, Weber F, Herold S, Pöhlmann S, Matrosovich M., Free PMC Article | 07/29/2017 |
| IFITM2 and IFITM3 specifically antagonize the HIV-1 envelope glycoprotein (Env), thereby inhibiting viral infection. | IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
Yu J, Li M, Wilkins J, Ding S, Swartz TH, Esposito AM, Zheng YM, Freed EO, Liang C, Chen BK, Liu SL., Free PMC Article | 07/16/2016 |
| propose that the IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation and demonstrate that the actions of the IFITM proteins are indeed virus and cell-type specific | The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.
Narayana SK, Helbig KJ, McCartney EM, Eyre NS, Bull RA, Eltahla A, Lloyd AR, Beard MR., Free PMC Article | 02/27/2016 |
| G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. | G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.
Bidet K, Dadlani D, Garcia-Blanco MA., Free PMC Article | 11/7/2015 |
| In virus-producing cells, IFITMs coalesce with forming virions and are incorporated into HIV-1 viral particles. | IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
Tartour K, Appourchaux R, Gaillard J, Nguyen XN, Durand S, Turpin J, Beaumont E, Roch E, Berger G, Mahieux R, Brand D, Roingeard P, Cimarelli A., Free PMC Article | 10/17/2015 |
| Incorporation of IFITM1, IFITM2 and IFITM3 into HIV-1 virions impair viral fusion and spread. | IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
Compton AA, Bruel T, Porrot F, Mallet A, Sachse M, Euvrard M, Liang C, Casartelli N, Schwartz O., Free PMC Article | 09/26/2015 |
| Host IFITM3,IFITM2 and IFITM1 facilitate morphogenesis of the human cytomegalovirus assembly. | Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.
Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, Zhang J, Yu D, Li B, Qian Z., Free PMC Article | 05/30/2015 |
| Although their inhibitory activities were modest when compared to that of tetherin, IFITMs, but not tetherin, directly reduced the expression of HIV-1 proteins including Gag, Vif and Nef. | Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins.
Chutiwitoonchai N, Hiyoshi M, Hiyoshi-Yoshidomi Y, Hashimoto M, Tokunaga K, Suzu S., Free PMC Article | 09/28/2013 |
| Authors show that interferon-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity against several members of the Bunyaviridae family. | IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.
Mudhasani R, Tran JP, Retterer C, Radoshitzky SR, Kota KP, Altamura LA, Smith JM, Packard BZ, Kuhn JH, Costantino J, Garrison AR, Schmaljohn CS, Huang IC, Farzan M, Bavari S., Free PMC Article | 09/21/2013 |