| BIG1 and BIG2 knockdown significantly decreased the levels of VEGF mRNA and protein in glioblastoma U251 cells and HUVECs. Furthermore, depletion of BIG1 and BIG2 inhibited HUVEC angiogenesis by diminishing cell migration. | Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.
Lu FI, Wang YT, Wang YS, Wu CY, Li CC. | 06/6/2020 |
| Both phospholipase D activity and vesicular trafficking were required for effects of BIG1 and BIG2 on beta-catenin activation. Levels of PKA-phosphorylated beta-catenin S675 and beta-catenin association with PKA, BIG1, and BIG2 were also diminished after BIG1/BIG2 depletion. | Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.
Li CC, Le K, Kato J, Moss J, Vaughan M., Free PMC Article | 12/24/2016 |
| Description of a novel ARFGEF2 mutation in five related patients presenting with West syndrome, microcephaly, periventricular heterotopia and thin corpus callosum. | West syndrome, microcephaly, grey matter heterotopia and hypoplasia of corpus callosum due to a novel ARFGEF2 mutation.
Banne E, Atawneh O, Henneke M, Brockmann K, Gärtner J, Elpeleg O, Edvardson S. | 09/20/2014 |
| The clinical phenotype associated with mutations in ARFGEF2 is relatively homogeneous in the families report. | Elaborating the phenotypic spectrum associated with mutations in ARFGEF2: case study and literature review.
Tanyalçin I, Verhelst H, Halley DJ, Vanderhasselt T, Villard L, Goizet C, Lissens W, Mancini GM, Jansen AC. | 07/5/2014 |
| Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex. | Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.
Le K, Li CC, Ye G, Moss J, Vaughan M., Free PMC Article | 11/30/2013 |
| an early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum. | The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
Lowery J, Szul T, Styers M, Holloway Z, Oorschot V, Klumperman J, Sztul E., Free PMC Article | 06/15/2013 |
| Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin beta1 cycling and actin remodeling. | Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin β1 cycling and actin remodeling.
Shen X, Li CC, Aponte AM, Shen RF, Billings EM, Moss J, Vaughan M., Free PMC Article | 12/8/2012 |
| Up-regulation of ARFGEF2 is associated with the Huntington's disease. | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (ARFGEF2): a new potential biomarker in Huntington's disease.
Lovrecic L, Slavkov I, Dzeroski S, Peterlin B. | 03/12/2011 |
| BIG1 and BIG2 have roles in endomembrane organization | Specific functions of BIG1 and BIG2 in endomembrane organization.
Boal F, Stephens DJ., Free PMC Article | 01/15/2011 |
| Results describe a child with a severe choreadystonic movement disorder, bilateral periventricular nodular heterotopia (BPNH), and secondary microcephaly based on compound heterozygosity for two new ARFGEF2 mutations. | Movement disorder and neuronal migration disorder due to ARFGEF2 mutation.
de Wit MC, de Coo IF, Halley DJ, Lequin MH, Mancini GM., Free PMC Article | 01/21/2010 |
| These observations indicate that BIG2 and BIG1 play redundant roles in trafficking between the trans-Golgi network and endosomes that involves the AP-1 complex. | Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.
Ishizaki R, Shin HW, Mitsuhashi H, Nakayama K., Free PMC Article | 01/21/2010 |
| COPII is the only coat required for sorting and export from the endoplasmic reticulum exit sites, whereas GBF1 but not BIGs, is required for COPI recruitment, Golgi subcompartmentalization, and cargo progression to the cell surface. | Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.
Manolea F, Claude A, Chun J, Rosas J, Melançon P., Free PMC Article | 01/21/2010 |
| both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C | cAMP-dependent protein kinase A (PKA) signaling induces TNFR1 exosome-like vesicle release via anchoring of PKA regulatory subunit RIIbeta to BIG2.
Islam A, Jones H, Hiroi T, Lam J, Zhang J, Moss J, Vaughan M, Levine SJ., Free PMC Article | 01/21/2010 |
| identification of protein kinase A-anchoring domains | Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).
Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M., Free PMC Article | 01/21/2010 |
| BIG2 and Exo70 interact in trans-Golgi network and centrosomes, as well as in exocyst structures or complexes that move along microtubules to the plasma membrane. | Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70.
Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M., Free PMC Article | 01/21/2010 |
| Regulates the constitutive release of tumor necrosis factor receptor type 1 exosome-like vesicles from vascular endothelial cells. | The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles.
Islam A, Shen X, Hiroi T, Moss J, Vaughan M, Levine SJ. | 01/21/2010 |
| ARFGEF2 mRNA was widely expressed in all cortical layers, especially in the neural precursors of the ventricular and subventricular zones during development, with persistent but diminished expression in adulthood. | Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia.
Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V. | 01/21/2010 |
| involvement in molecular mechanisms of vesicular transport | BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors.
Pacheco-Rodriguez G, Moss J, Vaughan M. | 01/21/2010 |
| Phosphorylation of BIG1 and BIG2 via PKA and protein phosphatase 1gamma effects vesicular trafficking via alterations in ARF activation. | Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.
Kuroda F, Moss J, Vaughan M., Free PMC Article | 01/21/2010 |