| Defective Lamtor5 Leads to Autoimmunity by Deregulating v-ATPase and Lysosomal Acidification. | Defective Lamtor5 Leads to Autoimmunity by Deregulating v-ATPase and Lysosomal Acidification.
Zhang W, Sha Z, Tang Y, Jin C, Gao W, Chen C, Yu L, Lv N, Liu S, Xu F, Wang D, Shi L., Free PMC Article | 06/15/2024 |
| Research progress on oncoprotein hepatitis B X-interacting protein (Review). | Research progress on oncoprotein hepatitis B X‑interacting protein (Review).
Cheng L, Guo L, Zou T, Yang Y, Tao R, Liu S., Free PMC Article | 04/8/2024 |
| HBXIP is a novel regulator of the unfolded protein response that sustains tamoxifen resistance in ER+ breast cancer. | HBXIP is a novel regulator of the unfolded protein response that sustains tamoxifen resistance in ER+ breast cancer.
Zhang S, Wang R, Wang X, Guo X, Du Y, Guo X, Zong X, Zhu C, Zhou X., Free PMC Article | 04/30/2022 |
| High HBXIP expression is related to poor prognosis in HCC by extensive database interrogation. | High HBXIP expression is related to poor prognosis in HCC by extensive database interrogation.
Guo ZY, Jiang LP, Zhu ZT. | 03/26/2022 |
| The modulation of PD-L1 induced by the oncogenic HBXIP for breast cancer growth. | The modulation of PD-L1 induced by the oncogenic HBXIP for breast cancer growth.
Xu FF, Sun HM, Fang RP, Zhang L, Shi H, Wang X, Fu XL, Li XM, Shi XH, Wu Y, Ye K, Zhang WY, Ye LH., Free PMC Article | 03/19/2022 |
| LAMTOR5 expression level is a biomarker for colorectal cancer and lncRNA LAMTOR5-AS1 predicting miRNA sponging effect. | LAMTOR5 expression level is a biomarker for colorectal cancer and lncRNA LAMTOR5-AS1 predicting miRNA sponging effect.
Zaniani NR, Oroujalian A, Valipour A, Peymani M. | 01/29/2022 |
| Oncoprotein HBXIP promotes tumorigenesis through MAPK/ERK pathway activation in non-small cell lung cancer. | Oncoprotein HBXIP promotes tumorigenesis through MAPK/ERK pathway activation in non-small cell lung cancer.
Zhang J, Sun B, Ruan X, Hou X, Zhi J, Meng X, Zheng X, Gao M., Free PMC Article | 12/18/2021 |
| HBXIP accelerates glycolysis and promotes cancer angiogenesis via AKT/mTOR pathway in bladder cancer. | HBXIP accelerates glycolysis and promotes cancer angiogenesis via AKT/mTOR pathway in bladder cancer.
Liu X, Li H, Che N, Zheng Y, Fan W, Li M, Li X, Xuan Y. | 11/13/2021 |
| HBXIP drives metabolic reprogramming in hepatocellular carcinoma cells via METTL3-mediated m6A modification of HIF-1alpha. | HBXIP drives metabolic reprogramming in hepatocellular carcinoma cells via METTL3-mediated m6A modification of HIF-1α.
Yang N, Wang T, Li Q, Han F, Wang Z, Zhu R, Zhou J. | 10/2/2021 |
| Down-Regulation of HBXIP Inhibits Non-Small Cell Lung Cancer Growth and Enhances the Anti-Tumor Immunity of Mice by Reducing NRP-1. | Down-Regulation of HBXIP Inhibits Non-Small Cell Lung Cancer Growth and Enhances the Anti-Tumor Immunity of Mice by Reducing NRP-1.
Wang L, Sun M, Lin X, Lei Y, Yin Z, Zhou W. | 09/11/2021 |
| HBXIP promotes gastric cancer via METTL3-mediated MYC mRNA m6A modification. | HBXIP promotes gastric cancer via METTL3-mediated MYC mRNA m6A modification.
Yang Z, Jiang X, Li D, Jiang X., Free PMC Article | 05/22/2021 |
| LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity. | LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity.
Fang R, Xu F, Shi H, Wu Y, Cao C, Li H, Ye K, Zhang Y, Liu Q, Zhang S, Zhang W, Ye L. | 01/16/2021 |
| The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth. | The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth.
Wu Y, Wang X, Xu F, Zhang L, Wang T, Fu X, Jin T, Zhang W, Ye L., Free PMC Article | 09/12/2020 |
| biomarker of colorectal cancer which promotes invasion and migration via epithelial-mesenchymal transition | HBXIP: a potential prognosis biomarker of colorectal cancer which promotes invasion and migration via epithelial-mesenchymal transition.
Wang X, Feng Q, Yu H, Zhou X, Shan C, Zhang Q, Liu S. | 03/28/2020 |
| Study found LAMTOR5 was overexpressed in human and Pten cKO mice head and neck squamous cell carcinoma (HNSCC), and its expression was significantly associated with patients' overall survival, lymph node metastasis and lymph node grade. Furthermore, LAMTOR5 expression was significantly correlated with the expression of immune checkpoints and macrophage markers. | Increased Expression of LAMTOR5 Predicts Poor Prognosis and Is Associated with Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma.
Yang QC, Wu CC, Cao LY, Xiao Y, Li H, Liu B, Sun ZJ., Free PMC Article | 02/15/2020 |
| HBXIP elevated HOXB13 protein level in breast cancer cells. Mechanistically, HBXIP prevented chaperone-mediated autophagy (CMA)-dependent degradation of HOXB13 via enhancement of HOXB13 acetylation at the lysine 277 residue, causing the accumulation of HOXB13. | Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer.
Liu B, Wang T, Wang H, Zhang L, Xu F, Fang R, Li L, Cai X, Wu Y, Zhang W, Ye L., Free PMC Article | 10/26/2019 |
| The HBXIP-mediated reduction in NRF2-KEAP1 complexes promotes NRF2 accumulation. | The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis.
Zhou XL, Zhu CY, Wu ZG, Guo X, Zou W. | 10/12/2019 |
| The HBXIP induces PKM2 through transcription factor E2F1 to facilitate ER+ breast cancer cell proliferation. | Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Liu BW, Wang TJ, Li LL, Zhang L, Liu YX, Feng JY, Wu Y, Xu FF, Zhang QS, Bao MZ, Zhang WY, Ye LH., Free PMC Article | 09/14/2019 |
| Oncogenic HBXIP is a new direct target of tumor suppressive miR-145. Our findings reveal that miR-145-targeting HBXIP could be a potential therapeutic target in breast cancer. | MiR-145-targeted HBXIP modulates human breast cancer cell proliferation.
Jiang Y, Wang D, Ren H, Shi Y, Gao Y., Free PMC Article | 08/24/2019 |
| Oncogenic HBXIP controls the transcription regulation of ZEB1 by co-activating Sp1, thereby accelerating breast cancer growth. | Oncogenic HBXIP enhances ZEB1 through Sp1 to accelerate breast cancer growth.
Jiang Y, Wang D, Ren H, Shi Y, Gao Y., Free PMC Article | 08/17/2019 |
| We present association between HBXIP expression and the pathological features of patients with pancreatic ductal adenocarcinoma | HBXIP protein overexpression predicts the poor prognosis of pancreatic ductal adenocarcinomas.
Zhou X, Wang X, Duan J, Sun W, Chen Z, Li Q, Ou Z, Jiang G, Ren X, Liu S. | 03/23/2019 |
| Overexpression of HBXIP gene promotes adenoic cystic carcinoma cell ine ACC-M proliferation, invasion and migration. Further, ACC-M proliferation, invasion and migration may be promoted by increased Akt, PI3K phosphorylation and S100A4 protein expression. | [Effect of HBXIP on biological function and PI3K/Akt signaling pathway of adenoid cystic carcinoma cell line ACC-M].
Meng X, Qi XY, Wang QX, Liu WX. | 02/16/2019 |
| HBXIP suppresses miR-18b to elevate MDM2 and activates pAKT to phosphorylate MDM2 for enhancing the interaction between MDM2 and p53, leading to p53 degradation in promotion of breast cancer growth | The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways.
Li H, Wang Z, Jiang M, Fang RP, Shi H, Shen Y, Cai XL, Liu Q, Ye K, Fan SJ, Zhang WY, Ye LH., Free PMC Article | 01/19/2019 |
| Data show that hepatitis B X-interacting protein (HBXIP) modulated Methyltransferase-like 3 (METTL3) by inhibiting miRNA let-7g, which down-regulated the expression of METTL3 by targeting its 3'UTR. | HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g.
Cai X, Wang X, Cao C, Gao Y, Zhang S, Yang Z, Liu Y, Zhang X, Zhang W, Ye L. | 10/27/2018 |
| Those findings highlight the potential role of SIRT2 in HBV and HBV-mediated HCC by interaction with HBx. | HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis.
Cheng ST, Ren JH, Cai XF, Jiang H, Chen J. | 02/24/2018 |