| Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway. | Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway.
Xu S, Xing J, Li K, Qiao L, Zhang C, Ren Y, Liu Y., Free PMC Article | 06/14/2024 |
| Binding between ROCK1 and DCTN2 triggers diabetesassociated centrosome amplification in colon cancer cells. | Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells.
Li YF, Shi LJ, Wang P, Wang JW, Shi GY, Lee SC., Free PMC Article | 12/4/2021 |
| This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. | Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.
Braathen GJ, Høyer H, Busk ØL, Tveten K, Skjelbred CF, Russell MB., Free PMC Article | 12/17/2016 |
| dynamitin is involved in the regulation of Nav1.5 cell-surface density | Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5.
Chatin B, Colombier P, Gamblin AL, Allouis M, Le Bouffant F. | 12/20/2014 |
| the determinants of p50/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin complex | Molecular and functional basis for the scaffolding role of the p50/dynamitin subunit of the microtubule-associated dynactin complex.
Jacquot G, Maidou-Peindara P, Benichou S., Free PMC Article | 08/23/2010 |
| The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner. | N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.
Inoue M, Arasaki K, Ueda A, Aoki T, Tagaya M. | 01/21/2010 |
| Data show how dynamitin's different structural domains contribute to its ability to self-associate, interact with dynactin and assemble into a complex with its close binding partner, p24. | Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure.
Maier KC, Godfrey JE, Echeverri CJ, Cheong FK, Schroer TA., Free PMC Article | 01/21/2010 |
| the Sec23p component of the COPII complex directly interacts with the dynactin complex through the carboxy-terminal cargo-binding domain of p150(Glued). | Coupling of ER exit to microtubules through direct interaction of COPII with dynactin.
Watson P, Forster R, Palmer KJ, Pepperkok R, Stephens DJ., Free PMC Article | 01/21/2010 |
| study does not support a major role for DCTN2 overexpression in carcinogenesis | Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells.
Bransfield KL, Askham JM, Leek JP, Robinson PA, Mighell AJ. | 01/21/2010 |
| DCTN2 is required in the earliest stages of peroxisome biogenesis. | Requirement for microtubules and dynein motors in the earliest stages of peroxisome biogenesis.
Brocard CB, Boucher KK, Jedeszko C, Kim PK, Walton PA. | 01/21/2010 |
| Altered levels of Cep135 and p50 by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes. | Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes.
Uetake Y, Terada Y, Matuliene J, Kuriyama R. | 01/21/2010 |