| CAP2 contributes to Parkinson's disease diagnosed by neutrophil extracellular trap-related immune activity. | CAP2 contributes to Parkinson's disease diagnosed by neutrophil extracellular trap-related immune activity.
Li X, Luo M, Xu H, Jia L, Liang Y, Xu Q, Wang Y., Free PMC Article | 10/29/2024 |
| An association study of cyclase-associated protein 2 and frailty. | An association study of cyclase-associated protein 2 and frailty.
Pelucchi S, Macchi C, D'Andrea L, Rossi PD, Speciani MC, Stringhi R, Ruscica M, Arosio B, Di Luca M, Cesari M, Edefonti V, Marcello E., Free PMC Article | 09/14/2023 |
| Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes in Post-Mortem Brain of Schizophrenia, Parkinson's and Alzheimer's Disease Patients. | Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes in Post-Mortem Brain of Schizophrenia, Parkinson's and Alzheimer's Disease Patients.
Di Maio A, De Rosa A, Pelucchi S, Garofalo M, Marciano B, Nuzzo T, Gardoni F, Isidori AM, Di Luca M, Errico F, De Bartolomeis A, Marcello E, Usiello A., Free PMC Article | 03/19/2022 |
| Endoplasmic Reticulum Stress Induces CAP2 Expression Promoting Epithelial-Mesenchymal Transition in Liver Cancer Cells. | Endoplasmic Reticulum Stress Induces CAP2 Expression Promoting Epithelial-Mesenchymal Transition in Liver Cancer Cells.
Yoon S, Shin B, Woo HG., Free PMC Article | 01/8/2022 |
| CAP2 is a Valuable Biomarker for Diagnosis and Prognostic in Patients with Gastric Cancer. | CAP2 is a Valuable Biomarker for Diagnosis and Prognostic in Patients with Gastric Cancer.
Li L, Fu LQ, Wang HJ, Wang YY. | 01/16/2021 |
| CAP2 expression in ovarian cancer is an independent prognostic factor for recurrence-free survival. | Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer correlates with aggressive histologic types and worse outcomes.
Adachi M, Masugi Y, Yamazaki K, Emoto K, Kobayashi Y, Tominaga E, Banno K, Aoki D, Sakamoto M. | 07/11/2020 |
| CAP2 joins other regulators of actin dynamics demonstrated to cause human genetic diseases. Our study is the first to demonstrate a mutation in CAP2 in human and a direct role for mutated CAP2 and perturbation of actin dynamics in the pathogenesis of DCM and possibly also conduction abnormalities in humans. | CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy.
Aspit L, Levitas A, Etzion S, Krymko H, Slanovic L, Zarivach R, Etzion Y, Parvari R. | 05/23/2020 |
| Study used lysine-to-glutamine mutations to map the relevant lysines on actin for INF2 regulation. K50Q- and K61Q-actin, when bound to CAP2, inhibit full-length INF2 but not INF2 lacking inhibitory domain (DID). CAP WH2 domain binds INF2-DID with submicromolar affinity but has weak affinity for actin monomers, while INF2-C-terminal diaphanous autoregulatory domain binds CAP/K50Q-actin 5-fold better than CAP/WT-actin. | Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself.
A M, Fung TS, Francomacaro LM, Huynh T, Kotila T, Svindrych Z, Higgs HN., Free PMC Article | 05/16/2020 |
| CAP2 is highly expressed in gastric cancer tissues in close relation with the tumor progression. CAP2 is an independent risk factor for 5-year survival rate after radical gastrectomy for gastric cancer. | [Association of adenylate cyclase-associated protein 2 expression with histopathology and long-term prognosis of gastric cancer].
Ge S, Wang S, Xiang W, Wang L, Zhu Y, Zhu X, Wang X, Zuo L, Jiang C, Li S, Liu M., Free PMC Article | 11/16/2019 |
| CAP2 overexpression is a novel prognostic marker in malignant melanoma. CAP2 expression seems to increase stepwise during tumor progression, suggesting the involvement of CAP2 in the aggressive behavior of malignant melanoma. | Overexpression of adenylate cyclase-associated protein 2 is a novel prognostic marker in malignant melanoma.
Masugi Y, Tanese K, Emoto K, Yamazaki K, Effendi K, Funakoshi T, Mori M, Sakamoto M. | 04/22/2017 |
| CAP2 is upregulated in breast cancer and is associated with the expression of progesterone receptor and patient survival | Expression status of cyclase‑associated protein 2 as a prognostic marker for human breast cancer.
Xu L, Peng S, Huang Q, Liu Y, Jiang H, Li X, Wang J. | 03/4/2017 |
| An important conserved function of CAP2 in higher vertebrates may be associated with the process of skeletal muscle development. | Involvement of hepatocellular carcinoma biomarker, cyclase-associated protein 2 in zebrafish body development and cancer progression.
Effendi K, Yamazaki K, Mori T, Masugi Y, Makino S, Sakamoto M. | 01/26/2013 |
| CAP2 is up-regulated in human cancers and that is possibly related to multistage hepatocarcinogenesis. | Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis.
Shibata R, Mori T, Du W, Chuma M, Gotoh M, Shimazu M, Ueda M, Hirohashi S, Sakamoto M. | 01/21/2010 |