| Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2. | Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2.
Torii S, Arakawa S, Sato S, Ishikawa KI, Taniguchi D, Sakurai HT, Honda S, Hiraoka Y, Ono M, Akamatsu W, Hattori N, Shimizu S., Free PMC Article | 09/12/2023 |
| CK1delta over-expressing mice display ADHD-like behaviors, frontostriatal neuronal abnormalities and altered expressions of ADHD-candidate genes. | CK1δ over-expressing mice display ADHD-like behaviors, frontostriatal neuronal abnormalities and altered expressions of ADHD-candidate genes.
Zhou M, Gresack J, Cheng J, Uryu K, Brichta L, Greengard P, Flajolet M., Free PMC Article | 06/12/2021 |
| Therapeutic Targeting of Casein Kinase 1delta/epsilon in an Alzheimer's Disease Mouse Model. | Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model.
Adler P, Mayne J, Walker K, Ning Z, Figeys D. | 08/15/2020 |
| These data implicate the autophosphorylation activity of CK1delta and CK1epsilon kinases in setting the pace of mammalian circadian rhythms and indicate that the circadian period can be modulated by tuning the autophosphorylation rates of CK1delta/epsilon. | Autokinase Activity of Casein Kinase 1 δ/ε Governs the Period of Mammalian Circadian Rhythms.
Guo G, Wang K, Hu SS, Tian T, Liu P, Mori T, Chen P, Johnson CH, Qin X., Free PMC Article | 07/25/2020 |
| CK1delta/epsilon disruption mouse had a long (27.4 h) behavioral period to which peripheral clocks entrained in vivo, albeit with an advanced phase ( approximately 6 h). | Desynchrony between brain and peripheral clocks caused by CK1δ/ε disruption in GABA neurons does not lead to adverse metabolic outcomes.
van der Vinne V, Swoap SJ, Vajtay TJ, Weaver DR., Free PMC Article | 11/3/2018 |
| Studied roles of CK1delta and CK1e in regulation of PER2 in circadian rhythm. | CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.
Narasimamurthy R, Hunt SR, Lu Y, Fustin JM, Okamura H, Partch CL, Forger DB, Kim JK, Virshup DM., Free PMC Article | 09/8/2018 |
| the impact of obesity on the circadian system in mice at a behavioural and molecular level was assessed, and determined whether pharmacological targeting of casein kinase 1delta and epsilon (CK1delta/epsilon), key regulators of the circadian clock, can confer metabolic benefit. | Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.
Cunningham PS, Ahern SA, Smith LC, da Silva Santos CS, Wager TT, Bechtold DA., Free PMC Article | 06/9/2018 |
| Here, the authors identify another Wnt signaling amplifier, CKIepsilon, which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta. | Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.
Morgenstern Y, Das Adhikari U, Ayyash M, Elyada E, Tóth B, Moor A, Itzkovitz S, Ben-Neriah Y., Free PMC Article | 10/21/2017 |
| Report temperature-compensated CKIdelta-dependent multi-site phosphorylation in mammals underlies temperature compensated phosphorylation in circadian clocks. | Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock.
Shinohara Y, Koyama YM, Ukai-Tadenuma M, Hirokawa T, Kikuchi M, Yamada RG, Ukai H, Fujishima H, Umehara T, Tainaka K, Ueda HR. | 09/30/2017 |
| Together, these findings suggest that CK1delta contributes to the efficient repair of DNA damage and the proper functioning of mitotic checkpoints by maintaining appropriate levels of Chk1. | Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1.
Greer YE, Gao B, Yang Y, Nussenzweig A, Rubin JS., Free PMC Article | 08/19/2017 |
| we conclude that APC/C(Cdh1) controls CK1 delta levels to balance proliferation and cell-cycle exit in the developing CNS | Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.
Penas C, Govek EE, Fang Y, Ramachandran V, Daniel M, Wang W, Maloof ME, Rahaim RJ, Bibian M, Kawauchi D, Finkelstein D, Han JL, Long J, Li B, Robbins DJ, Malumbres M, Roussel MF, Roush WR, Hatten ME, Ayad NG., Free PMC Article | 01/16/2016 |
| CK1delta mediates primary ciliogenesis by multiple mechanisms, one involving its centrosomal function and another dependent on its interaction with AKAP450 at the Golgi. | Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.
Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS., Free PMC Article | 01/17/2015 |
| this article reports the crystallization and structure determination of a new crystal form of casein kinase I delta belonging to space group P21. | A monoclinic crystal form of casein kinase 1 δ.
Zeringo NA, Murphy L, McCloskey EA, Rohal L, Bellizzi JJ 3rd., Free PMC Article | 05/17/2014 |
| decreases in CKIdelta activity can contribute to the pathogenesis of migraine. | Casein kinase iδ mutations in familial migraine and advanced sleep phase.
Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptáček LJ., Free PMC Article | 01/18/2014 |
| REGgamma-deficient mice develop premature aging phenotypes that are associated with abnormal accumulation of casein kinase (CK)1delta and p53. Antibody array analysis identified CK1delta as a direct target of REGgamma. | REGγ deficiency promotes premature aging via the casein kinase 1 pathway.
Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X., Free PMC Article | 09/28/2013 |
| inactivating mutations in CK1delta impair SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo | Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo.
Hirner H, Günes C, Bischof J, Wolff S, Grothey A, Kühl M, Oswald F, Wegwitz F, Bösl MR, Trauzold A, Henne-Bruns D, Peifer C, Leithäuser F, Deppert W, Knippschild U., Free PMC Article | 05/19/2012 |
| CK1delta plays a more prominent role than CK1epsilon in the maintenance of 24-hour rhythms in the master circadian oscillator | Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro.
Etchegaray JP, Yu EA, Indic P, Dallmann R, Weaver DR., Free PMC Article | 06/18/2011 |
| These results provide strong evidence that the centrosomal localization of CK1delta is required for Wnt-3a-dependent neuritogenesis. | Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.
Greer YE, Rubin JS., Free PMC Article | 05/21/2011 |
| The results suggest that CK1delta/epsilon binds to and phosphorylates the N-terminal domain of Dnmt1 and regulates Dnmt1 function by reducing the DNA-binding activity. | The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon.
Sugiyama Y, Hatano N, Sueyoshi N, Suetake I, Tajima S, Kinoshita E, Kinoshita-Kikuta E, Koike T, Kameshita I. | 05/3/2010 |
| physical interaction between PER and CKIdelta/epsilon required for circadian rhythm | Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.
Lee H, Chen R, Lee Y, Yoo S, Lee C., Free PMC Article | 02/15/2010 |
| The degradation rate of PER2, which is regulated by CKIepsilon/delta-dependent phosphorylation, was temperature-insensitive in living clock cells. | CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.
Isojima Y, Nakajima M, Ukai H, Fujishima H, Yamada RG, Masumoto KH, Kiuchi R, Ishida M, Ukai-Tadenuma M, Minami Y, Kito R, Nakao K, Kishimoto W, Yoo SH, Shimomura K, Takao T, Takano A, Kojima T, Nagai K, Sakaki Y, Takahashi JS, Ueda HR., Free PMC Article | 01/21/2010 |
| generated mice with liver-specific disruption of CK1delta. In livers from these mice, daytime levels of nuclear PER proteins, and PER-CRY-CLOCK complexes were elevated. In vitro, the half-life of PER2 was increased by approximately 20%. | Casein kinase 1 delta regulates the pace of the mammalian circadian clock.
Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR., Free PMC Article | 01/21/2010 |
| The balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated. | Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways.
Bryja V, Schambony A, Cajánek L, Dominguez I, Arenas E, Schulte G., Free PMC Article | 01/21/2010 |
| CK1 regulates fast synaptic transmission by glutamate in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 &/or 2A & increased dephosphorylation of NMDA receptors. | Physiological role for casein kinase 1 in glutamatergic synaptic transmission.
Chergui K, Svenningsson P, Greengard P., Free PMC Article | 01/21/2010 |
| Results indicate that CKIdelta plays several roles in lymphocyte physiology. | Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology.
Maritzen T, Löhler J, Deppert W, Knippschild U. | 01/21/2010 |