| Histone Demethylase KDM3 (JMJD1) in Transcriptional Regulation and Cancer Progression. | Histone Demethylase KDM3 (JMJD1) in Transcriptional Regulation and Cancer Progression.
Fan L, Sudeep K, Qi J., Free PMC Article | 09/29/2023 |
| LncRNA HOX transcript antisense RNA mitigates cardiac function injury in chronic heart failure via regulating microRNA-30a-5p to target KDM3A. | LncRNA HOX transcript antisense RNA mitigates cardiac function injury in chronic heart failure via regulating microRNA-30a-5p to target KDM3A.
Zhang X, Gao Y, Wu H, Mao Y, Qi Y., Free PMC Article | 04/30/2022 |
| MiR-216a-5p alleviates chronic constriction injury-induced neuropathic pain in rats by targeting KDM3A and inactivating Wnt/beta-catenin signaling pathway. | MiR-216a-5p alleviates chronic constriction injury-induced neuropathic pain in rats by targeting KDM3A and inactivating Wnt/β-catenin signaling pathway.
Wang W, Li R. | 09/18/2021 |
| MicroRNA-194 acts as a suppressor during abdominal aortic aneurysm via inhibition of KDM3A-mediated BNIP3. | MicroRNA-194 acts as a suppressor during abdominal aortic aneurysm via inhibition of KDM3A-mediated BNIP3.
Zhang H, Wang Y, Bian X, Yin H. | 06/26/2021 |
| H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline. | H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline.
Kuroki S, Maeda R, Yano M, Kitano S, Miyachi H, Fukuda M, Shinkai Y, Tachibana M., Free PMC Article | 06/5/2021 |
| JMJD1A Represses the Development of Cardiomyocyte Hypertrophy by Regulating the Expression of Catalase. | JMJD1A Represses the Development of Cardiomyocyte Hypertrophy by Regulating the Expression of Catalase.
Zang R, Tan Q, Zeng F, Wang D, Yu S, Wang Q., Free PMC Article | 03/13/2021 |
| Lysine-specific demethylase 3A is important for autophagic occurrence. | Lysine-specific demethylase 3A is important for autophagic occurrence.
Kim J, Choi SA, Kim J, Kim H, Baek SH. | 11/28/2020 |
| JMJD1 A is a co-activator of EPO expression | Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia.
Tian Z, Yao L, Shen Y, Guo X, Duan X. | 12/7/2019 |
| JMJD1A and JMJD1B, in combination, ensure early embryogenesis and embryonic stem cell viability by establishing the correct Histone 3 lysine 9 methylated epigenome. | Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.
Kuroki S, Nakai Y, Maeda R, Okashita N, Akiyoshi M, Yamaguchi Y, Kitano S, Miyachi H, Nakato R, Ichiyanagi K, Shirahige K, Kimura H, Shinkai Y, Tachibana M., Free PMC Article | 04/27/2019 |
| JMJD1A mediates two major signaling pathways, namely, beta-adrenergic receptor and peroxisome proliferator-activated receptor-gamma (PPARgamma) activation, via PRDM16-PPARgamma-P-JMJD1A complex for beige adipogenesis. | Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.
Abe Y, Fujiwara Y, Takahashi H, Matsumura Y, Sawada T, Jiang S, Nakaki R, Uchida A, Nagao N, Naito M, Kajimura S, Kimura H, Osborne TF, Aburatani H, Kodama T, Inagaki T, Sakai J., Free PMC Article | 01/5/2019 |
| Data suggest a critical role for KDM3A in the PI3K/AP-1 oncogenic axis and propose a novel strategy for inhibition of KDM3A against liver tumor development under PI3K pathway activation. | Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.
Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, Koike K. | 12/2/2017 |
| JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the beta1-adrenergic receptor gene (Adrb1) and downstream targets including Ucp1 in brown adipocytes. | JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J., Free PMC Article | 03/5/2016 |
| Kdm3a localizes to cytoplasmic structures of maturing spermatids affected in Kdm3a mutant mice, which in turn display altered fractionation of beta-actin and gamma-tubulin. | Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis.
Kasioulis I, Syred HM, Tate P, Finch A, Shaw J, Seawright A, Fuszard M, Botting CH, Shirran S, Adams IR, Jackson IJ, van Heyningen V, Yeyati PL., Free PMC Article | 01/17/2015 |
| Results show that Jmjd1a was not essential for stem cell self-renewal but played a crucial role as a tumor suppressor. | The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Ueda J, Ho JC, Lee KL, Kitajima S, Yang H, Sun W, Fukuhara N, Zaiden N, Chan SL, Tachibana M, Shinkai Y, Kato H, Poellinger L., Free PMC Article | 11/22/2014 |
| Despite these differences in rats, genetic knockout of Kdm3a in mice resulted in no dramatic effect on immune system development and activation or EAE susceptibility and severity | A silent exonic SNP in kdm3a affects nucleic acids structure but does not regulate experimental autoimmune encephalomyelitis.
Gillett A, Bergman P, Parsa R, Bremges A, Giegerich R, Jagodic M., Free PMC Article | 10/4/2014 |
| Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination. | Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.
Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M. | 10/26/2013 |
| Exposing cells to either chemical or cellular sources of (*)NO resulted in a significant increase in dimethyl Lys-9 on histone 3 (H3K9me2), the preferred substrate for KDM3A. | Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases.
Hickok JR, Vasudevan D, Antholine WE, Thomas DD., Free PMC Article | 08/10/2013 |
| essential for spermatogenesis and plays a role in regulating fat metabolic gene expression in muscle and brown fat tissue | Histone demethylase JHDM2A is involved in male infertility and obesity.
Okada Y, Tateishi K, Zhang Y., Free PMC Article | 06/28/2010 |
| the Jmjd1a-controlled epigenetic histone modifications are crucial for Crem-regulated gene expression and spermatogenesis | Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis.
Liu Z, Zhou S, Liao L, Chen X, Meistrich M, Xu J., Free PMC Article | 03/1/2010 |
| Thus, H3K9 demethylase JHDM2a is a crucial regulator of genes involved in energy expenditure and fat storage, which suggests it is a previously unrecognized key regulator of obesity and metabolic syndrome. | Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.
Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, Naito M, Kodama T, Shinkai Y, Sakai J. | 01/21/2010 |
| Jhdm2a expression is induced by beta-adrenergic stimulation, and that Jhdm2a directly regulates peroxisome proliferator-activated receptor alpha (Ppara) and Ucp1 expression | Role of Jhdm2a in regulating metabolic gene expression and obesity resistance.
Tateishi K, Okada Y, Kallin EM, Zhang Y., Free PMC Article | 01/21/2010 |
| G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells | G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells.
Ma DK, Chiang CH, Ponnusamy K, Ming GL, Song H., Free PMC Article | 01/21/2010 |
| Jmjd1a coregulates myocardin-related transcription factor-A (MRTF-A) and myocardin-dependent transcription. | The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression.
Lockman K, Taylor JM, Mack CP. | 01/21/2010 |
| Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1, Tcfcp2l1, and Zfp57 and positively regulates the expression of these pluripotency-associated genes. | Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells.
Loh YH, Zhang W, Chen X, George J, Ng HH., Free PMC Article | 01/21/2010 |
| the mouse H3K9me2/1-specific demethylase JHDM2A (JmjC-domain-containing histone demethylase 2A, also known as JMJD1A) is essential for spermatogenesis | Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis.
Okada Y, Scott G, Ray MK, Mishina Y, Zhang Y. | 01/21/2010 |