| ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression. | ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression.
Park J, Lee J, Hur Y, Kim CJ, Kim HB, Um D, Kim DS, Lee JY, Park S, Park Y, Kim TK, Im SH, Kim SW, Kwok SK, Lee Y., | 06/17/2024 |
| Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity. | Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity.
Hu RD, Zhang W, Li L, Zuo ZQ, Ma M, Ma JF, Yin TT, Gao CY, Yang SH, Zhao ZB, Li ZJ, Qiao GB, Lian ZX, Qu K., Free PMC Article | 02/26/2022 |
| Establishment of Etv5 gene knockout mice as a recipient model for spermatogonial stem cell transplantation. | Establishment of Etv5 gene knockout mice as a recipient model for spermatogonial stem cell transplantation.
Zhang X, Zhao X, Li G, Zhang M, Xing P, Li Z, Chen B, Yang H, Wu Z., Free PMC Article | 01/1/2022 |
| Etv5 safeguards trophoblast stem cells differentiation from mouse EPSCs by regulating fibroblast growth factor receptor 2. | Etv5 safeguards trophoblast stem cells differentiation from mouse EPSCs by regulating fibroblast growth factor receptor 2.
Zhu K, Liu Y, Fan C, Zhang M, Cao H, He X, Li N, Chu D, Li F, Zou M, Hua J, Wang H, Wang Y, Fan G, Zhang S. | 05/29/2021 |
| ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway. | ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway.
Mao Z, Feng M, Li Z, Zhou M, Xu L, Pan K, Wang S, Su W, Zhang W. | 05/15/2021 |
| Etv transcription factors functionally diverge from their upstream FGF signaling in lens development. | Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
Garg A, Hannan A, Wang Q, Makrides N, Zhong J, Li H, Yoon S, Mao Y, Zhang X., Free PMC Article | 04/3/2021 |
| Derepression of Etv5 increases Hobit expression in Cic -deficient CD8+ T cells and consequently enhances CD8+ T memory cell formation in liver, thereby leading to liver injury. | The Capicua/ETS Translocation Variant 5 Axis Regulates Liver-Resident Memory CD8(+) T-Cell Development and the Pathogenesis of Liver Injury.
Park S, Park J, Kim E, Lee Y. | 06/27/2020 |
| Study found that ETV5 increased acyl ghrelin but not its total production; through the enhanced expression of GOAT enzyme. ETV5 transactivated GOAT promoter, leading to the subsequent increase of its expression. mTORC1 signaling inhibited the expression of ETV5 which deficiency attenuated the effect of mTORC1 signaling on GOAT/ghrelin. Therefore, ETV5 is a new transcription factor regulating GOAT expression. | ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner.
Mao Z, Yang Q, Yin W, Su W, Lin H, Feng M, Pan K, Yin Y, Zhang W. | 12/14/2019 |
| Etv5 can positively regulate primitive endoderm specification through regulating Gata6 and negatively regulate epiblast specification by inhibiting Fgf5 expression. | The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.
Zhang J, Cao H, Xie J, Fan C, Xie Y, He X, Liao M, Zhang S, Wang H., Free PMC Article | 09/14/2019 |
| CIC-ETV5 axis is critical for regulation of follicular helper T cell development | Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.
Park S, Lee S, Lee CG, Park GY, Hong H, Lee JS, Kim YM, Lee SB, Hwang D, Choi YS, Fryer JD, Im SH, Lee SW, Lee Y., Free PMC Article | 12/22/2018 |
| ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis | ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis.
Das KK, Heeg S, Pitarresi JR, Reichert M, Bakir B, Takano S, Kopp JL, Wahl-Feuerstein A, Hicks P, Sander M, Rustgi AK., Free PMC Article | 11/24/2018 |
| High Etv5 expression is associated with glioma. | Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma.
Pan Y, Duron C, Bush EC, Ma Y, Sims PA, Gutmann DH, Radunskaya A, Hardin J., Free PMC Article | 08/4/2018 |
| This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development. | Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper Hippocampal Dendrite Development and Plasticity.
Fontanet PA, Ríos AS, Alsina FC, Paratcha G, Ledda F. | 08/4/2018 |
| Etv5 is expressed alveolar type II cells in adult lung.Etv5 is a critical output of Ras signaling in alveolar type II cells, contributing to both lung homeostasis and tumor initiation. | Transcription factor Etv5 is essential for the maintenance of alveolar type II cells.
Zhang Z, Newton K, Kummerfeld SK, Webster J, Kirkpatrick DS, Phu L, Eastham-Anderson J, Liu J, Lee WP, Wu J, Li H, Junttila MR, Dixit VM., Free PMC Article | 05/26/2018 |
| SOX9 regulation of ETV5 contributes to the control of male fertility | SOX9 regulates expression of the male fertility gene Ets variant factor 5 (ETV5) during mammalian sex development.
Alankarage D, Lavery R, Svingen T, Kelly S, Ludbrook L, Bagheri-Fam S, Koopman P, Harley V. | 11/4/2017 |
| this study shows that Etv5 plays a crucial role in regulating IL-10 production in Th2 cells by facilitating the binding of IL-10-inducing transcription factors at the Il10 locus | Etv5 Regulates IL-10 Production in Th Cells.
Koh B, Hufford MM, Sun X, Kaplan MH., Free PMC Article | 09/23/2017 |
| findings demonstrate that ETV5 promotes IL-9 production in Th9 cells by binding and recruiting histone acetyltransferases to the Il9 locus at sites distinct from PU.1. data define a role for ETV5 in Th9 development and extend the paradigm of related transcription factors having complementary functions during differentiation | The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.
Koh B, Hufford MM, Pham D, Olson MR, Wu T, Jabeen R, Sun X, Kaplan MH., Free PMC Article | 08/19/2017 |
| substrate that mediates RFWD2 function in lung branching | E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors.
Zhang Y, Yokoyama S, Herriges JC, Zhang Z, Young RE, Verheyden JM, Sun X., Free PMC Article | 08/19/2017 |
| bioinformatic analysis, real-time PCR, and luciferase assay validated that AK015322 serves as a decoy of microRNA-19b-3p (miR-19b-3p), antagonizes its function, and attenuates the repression of its endogenous target transcriptional factor Ets-variant 5 (ETV5) which was a pivotal gene for spermatogonial stem cell self-renewal | LncRNA AK015322 promotes proliferation of spermatogonial stem cell C18-4 by acting as a decoy for microRNA-19b-3p.
Hu K, Zhang J, Liang M. | 04/1/2017 |
| Further investigations identified Pak1-ERM as a downstream signaling cascade upon Rac1 activation in the luminal epithelium necessary for uterine receptivity...Rac1 via P38 MAPK signaling ensures timely epithelial apoptotic death at postimplantation. | Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice.
Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S, Wu X, Wang H., Free PMC Article | 09/10/2016 |
| The data of this study suggested that the obesity-associated transcription factor ETV5 normally acts to diminish circulating glucocorticoids. | The obesity-associated transcription factor ETV5 modulates circulating glucocorticoids.
Gutierrez-Aguilar R, Thompson A, Marchand N, Dumont P, Woods SC, de Launoit Y, Seeley RJ, Ulrich-Lai YM., Free PMC Article | 05/14/2016 |
| ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells. | ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.
Akagi T, Kuure S, Uranishi K, Koide H, Costantini F, Yokota T., Free PMC Article | 12/5/2015 |
| Noise-decreased levels of ROCK2 results in reduction of phosphorylation of ERM that leads to depolymerization of actin filaments | Noise-induced cochlear F-actin depolymerization is mediated via ROCK2/p-ERM signaling.
Han Y, Wang X, Chen J, Sha SH., Free PMC Article | 06/27/2015 |
| The transcription factors Etv5 and STAt3 control TH17 cell development and allergic airway inflammation. | The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation.
Pham D, Sehra S, Sun X, Kaplan MH., Free PMC Article | 12/6/2014 |
| A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse. | A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse.
Jamsai D, Clark BJ, Smith SJ, Whittle B, Goodnow CC, Ormandy CJ, O'Bryan MK., Free PMC Article | 08/9/2014 |