| Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation. | Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation.
Jansen LR, Welch MA, Plant LD, Baro DJ., Free PMC Article | 09/4/2024 |
| LncRNA FOXD2-AS1 promotes cell proliferation and invasion of fibroblast-like synoviocytes by regulation of miR-331-3p/PIAS3 pathway in rheumatoid arthritis. | LncRNA FOXD2-AS1 promotes cell proliferation and invasion of fibroblast-like synoviocytes by regulation of miR-331-3p/PIAS3 pathway in rheumatoid arthritis.
Zhao Q, Zhao F, Liu C, Xu T, Song K. | 04/2/2022 |
| PIAS3 suppresses damage in an Alzheimer's disease cell model by inducing the STAT3-associated STAT3/Nestin/Nrf2/HO-1 pathway. | PIAS3 suppresses damage in an Alzheimer's disease cell model by inducing the STAT3-associated STAT3/Nestin/Nrf2/HO-1 pathway.
Li C, Wang R, Zhang Y, Hu C, Ma Q., Free PMC Article | 03/12/2022 |
| Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer. | Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer.
Jiang M, Zhang W, Zhang R, Liu P, Ye Y, Yu W, Guo X, Yu J. | 11/28/2020 |
| miR-199a-5p promotes proliferation and metastasis and epithelial-mesenchymal transition through targeting PIAS3 in cervical carcinoma. | miR-199a-5p promotes proliferation and metastasis and epithelial-mesenchymal transition through targeting PIAS3 in cervical carcinoma.
Qu D, Yang Y, Huang X. | 08/15/2020 |
| PIAS genes as disease markers in bipolar disorder. | PIAS genes as disease markers in bipolar disorder.
Sayad A, Taheri M, Azari I, Oskoei VK, Ghafouri-Fard S. | 08/15/2020 |
| Here we report that Csk is covalently modified by SUMO1 at lysine 53 (K53) both in vitro and in vivo. Treatment with hydrogen peroxide inhibited this modification to a certain extent, but PIAS3, identified as the main specific SUMO E3 ligase for Csk, could significantly enhance SUMO1-Csk level | SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function.
Cui N, Liu T, Guo Y, Dou J, Yang Q, Zhang H, Chen R, Wang Y, Zhao X, Yu J, Huang J., Free PMC Article | 12/21/2019 |
| a positive feedback loop between miR-181b and STAT3 that regulated the Warburg effect in colon cancer was also demonstrated. This study suggested miR-181b/PIAS3/STAT3 axis as a novel target for colon cancer treatment. | A positive feedback loop between miR-181b and STAT3 that affects Warburg effect in colon cancer via regulating PIAS3 expression.
Pan X, Feng J, Zhu Z, Yao L, Ma S, Hao B, Zhang G., Free PMC Article | 11/23/2019 |
| This study identified miR-18a as a suppressor of PIAS3 expression that is upregulated in malignant mesothelioma cells and whose inhibition can increase PIAS3 expression and suppress STAT3 activity. | Post-transcriptional regulation of PIAS3 expression by miR-18a in malignant mesothelioma.
He T, McColl K, Sakre N, Chen Y, Wildey G, Dowlati A., Free PMC Article | 08/24/2019 |
| PIAS3-mediated feedback loops control cell proliferation and function as robust driving forces for Colitis-associated colorectal cancer (CAC) progression. | PIAS3-mediated feedback loops promote chronic colitis-associated malignant transformation.
Ma J, Yang Y, Fu Y, Guo F, Zhang X, Xiao S, Zhu W, Huang Z, Zhang J, Chen J., Free PMC Article | 07/13/2019 |
| Concomitant gain of pSTAT3 Tyr705 and loss of PIAS3 appear critical for initiation and development of high-grade serous carcinoma. | STAT3/PIAS3 Levels Serve as "Early Signature" Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube.
Saini U, Suarez AA, Naidu S, Wallbillich JJ, Bixel K, Wanner RA, Bice J, Kladney RD, Lester J, Karlan BY, Goodfellow PJ, Cohn DE, Selvendiran K., Free PMC Article | 03/23/2019 |
| Study reports that SMAD6 is overexpressed in nuclei of glioma cells, which correlates with poor patient survival and regulates STAT3 activity via negatively regulating PIAS3. Mechanically, SMAD6 interacts directly with PIAS3, and this interaction is mediated through the Mad homology 2 domain of SMAD6 and the Ring domain of PIAS3. | Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition.
Jiao J, Zhang R, Li Z, Yin Y, Fang X, Ding X, Cai Y, Yang S, Mu H, Zong D, Chen Y, Zhang Y, Zou J, Shao J, Huang Z., Free PMC Article | 01/12/2019 |
| PAI-1 interacted with PIAS3 to regulate Stat3-dependent gene expression and miR-34a was transcriptionally suppressed by Stat3 to form a positive regulatory loop through Stat3 signaling in non-small cell lung cancer cells. | PAI-1/PIAS3/Stat3/miR-34a forms a positive feedback loop to promote EMT-mediated metastasis through Stat3 signaling in Non-small cell lung cancer.
Lin X, Lin BW, Chen XL, Zhang BL, Xiao XJ, Shi JS, Lin JD, Chen X. | 11/4/2017 |
| Levels of PIAS3 are significantly lower, in contrast with phosphorylation of STAT3, in women with endometriosis compared to women without endometriosis. | Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis.
Yoo JY, Jeong JW, Fazleabas AT, Tayade C, Young SL, Lessey BA., Free PMC Article | 10/28/2017 |
| TRIM8 activates STAT3 by suppressing the expression of PIAS3, an inhibitor of STAT3, most likely through E3-mediated ubiquitination and proteasomal degradation. | TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.
Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ., Free PMC Article | 10/28/2017 |
| Low PIAS3 expression is associated with breast cancer organoid invasiveness. | The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness.
Chandhoke AS, Chanda A, Karve K, Deng L, Bonni S., Free PMC Article | 10/14/2017 |
| SHP2, SOCS3 and PIAS3 levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 downregulation is more reversely correlated with STAT3 activation. In resveratrol-suppressed medulloblastoma cells with STAT3 downregulation and decreased incidence of STAT3 nuclear translocation, PIAS3 is upregulated, the SHP2 level remains unchanged and SOCS3 is downregulated. | SHP2, SOCS3 and PIAS3 Expression Patterns in Medulloblastomas: Relevance to STAT3 Activation and Resveratrol-Suppressed STAT3 Signaling.
Li C, Li H, Zhang P, Yu LJ, Huang TM, Song X, Kong QY, Dong JL, Li PN, Liu J., Free PMC Article | 06/24/2017 |
| The results revealed that although the expression levels of SOCS1, SOCS3 and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 downregulation is more negatively correlated with STAT3 activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome. | Correlative analyses of the expression levels of PIAS3, p-SHP2, SOCS1 and SOCS3 with STAT3 activation in human astrocytomas.
Liu LH, Li H, Cheng XX, Kong QY, Chen XY, Wu ML, Li Y, Liu J, Li C. | 05/20/2017 |
| 3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 signaling through the induction of PIAS3. | 3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 signaling through the induction of PIAS3.
Ko JH, Ho Baek S, Nam D, Chung WS, Lee SG, Lee J, Mo Yang W, Um JY, Seok Ahn K. | 03/25/2017 |
| PIAS3 may serve as a biomarker for predicting hormone therapy stratification, although it is limited to those breast cancer patients receiving hormone therapy. | Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy.
Yang SF, Hou MF, Chen FM, Ou-Yang F, Wu YC, Chai CY, Yeh YT., Free PMC Article | 10/1/2016 |
| Taken together, these results suggest that PIAS3 functions as a positive regulator of HIF-1alpha-mediated transcription by increasing its protein stability. | PIAS3 enhances the transcriptional activity of HIF-1α by increasing its protein stability.
Nakagawa K, Kohara T, Uehata Y, Miyakawa Y, Sato-Ueshima M, Okubo N, Asaka M, Takeda H, Kobayashi M. | 05/28/2016 |
| PIAS3 suppression may be protective against joint destruction in rheumatoid arthritis by regulating synoviocyte migration, invasion, and activation. | Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis.
Lao M, Shi M, Zou Y, Huang M, Ye Y, Qiu Q, Xiao Y, Zeng S, Liang L, Yang X, Xu H. | 05/28/2016 |
| PIAS3 primes ATR for checkpoint activation. | The SUMO (Small Ubiquitin-like Modifier) Ligase PIAS3 Primes ATR for Checkpoint Activation.
Wu CS, Zou L., Free PMC Article | 05/21/2016 |
| PIAS3 expression in squamous cell lung cancer is low and predicts overall survival | PIAS3 expression in squamous cell lung cancer is low and predicts overall survival.
Abbas R, McColl KS, Kresak A, Yang M, Chen Y, Fu P, Wildey G, Dowlati A., Free PMC Article | 12/19/2015 |
| Adenovirus E4-ORF3 targets PIAS3 and together with E1B-55K remodels SUMO2/SUMO3 Interactions in the nucleus and at virus genome replication domains. | Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains.
Higginbotham JM, O'Shea CC., Free PMC Article | 12/19/2015 |