| Orchestration of a blood-derived and ADARB1-centred network in Alzheimer's and Parkinson's disease. | Orchestration of a blood-derived and ADARB1-centred network in Alzheimer's and Parkinson's disease.
Song Z, Ding Q, Yang Y. | 09/1/2023 |
| Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis. | Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis.
Guo M, Chan THM, Zhou Q, An O, Li Y, Song Y, Tan ZH, Ng VHE, Peramangalam PS, Tan ZQ, Cao X, Iwanaga E, Matsuoka M, Ooi MGM, Jen WY, Koh LP, Chan E, Tan LK, Goh Y, Wang W, Koh BTH, Chun CM, Fullwood MJ, Chng WJ, Osato M, Pulikkan JA, Yang H, Chen L, Tenen DG. | 06/29/2023 |
| Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling. | Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling.
Liu Q, You B, Meng J, Huang CP, Dong G, Wang R, Chou F, Gao S, Chang C, Yeh S, Xu W., Free PMC Article | 12/24/2022 |
| ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations. | ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations.
Hajji K, Sedmík J, Cherian A, Amoruso D, Keegan LP, O'Connell MA., Free PMC Article | 10/1/2022 |
| Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity. | Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity.
Katrekar D, Xiang Y, Palmer N, Saha A, Meluzzi D, Mali P., Free PMC Article | 03/5/2022 |
| Developing PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing. | Developing PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing.
Li G, Wang Y, Li X, Wang Y, Huang X, Gao J, Hu X., Free PMC Article | 02/26/2022 |
| Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy. | Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy.
Maroofian R, Sedmík J, Mazaheri N, Scala M, Zaki MS, Keegan LP, Azizimalamiri R, Issa M, Shariati G, Sedaghat A, Beetz C, Bauer P, Galehdari H, O'Connell MA, Houlden H., Free PMC Article | 01/29/2022 |
| Short-Chain Guide RNA for Site-Directed A-to-I RNA Editing. | Short-Chain Guide RNA for Site-Directed A-to-I RNA Editing.
Nose K, Hidaka K, Yano T, Tomita Y, Fukuda M. | 10/23/2021 |
| ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair. | ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.
Jimeno S, Prados-Carvajal R, Fernández-Ávila MJ, Silva S, Silvestris DA, Endara-Coll M, Rodríguez-Real G, Domingo-Prim J, Mejías-Navarro F, Romero-Franco A, Jimeno-González S, Barroso S, Cesarini V, Aguilera A, Gallo A, Visa N, Huertas P., Free PMC Article | 10/16/2021 |
| What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs. | What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs.
Heraud-Farlow JE, Walkley CR., Free PMC Article | 08/14/2021 |
| Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing. | Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.
Freund EC, Sapiro AL, Li Q, Linder S, Moresco JJ, Yates JR 3rd, Li JB., Free PMC Article | 05/22/2021 |
| Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. | Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
Thuy-Boun AS, Thomas JM, Grajo HL, Palumbo CM, Park S, Nguyen LT, Fisher AJ, Beal PA., Free PMC Article | 09/26/2020 |
| ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus. | ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.
Yanai M, Kojima S, Sakai M, Komorizono R, Tomonaga K, Makino A., Free PMC Article | 09/5/2020 |
| that the mislocalization of ADAR2 in C9orf72 mediated amyotrophic lateral sclerosis/frontotemporal dementia is responsible for the alteration of RNA processing events that may impact vast cellular functions | ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, W Dickson D, Robertson J, Staats KA, Ichida JK, Petrucelli L, Van Keuren-Jensen K, Sattler R., Free PMC Article | 07/25/2020 |
| We also observe a dominance of long-range interactions within ADAR substrates and analyze differences between ADAR1 and ADAR2 editing substrates. Moreover, we unexpectedly discovered that ADAR proteins bind dsRNA substrates tandemly in vivo, each with a 50-bp footprint. | irCLASH reveals RNA substrates recognized by human ADARs.
Song Y, Yang W, Fu Q, Wu L, Zhao X, Zhang Y, Zhang R. | 07/18/2020 |
| AKT-1, -2, and -3 interact with both ADAR1p110 and ADAR2 and phosphorylate these RNA editases. Using site-directed mutagenesis of suspected AKT phosphorylation sites, AKT was found to primarily phosphorylate ADAR1p110 and ADAR2 on T738 and T553, respectively, and overexpression of the phosphomimic mutants ADAR1p110 (T738D) and ADAR2 (T553D) resulted in a 50-100% reduction in editase activity. | AKT-dependent phosphorylation of the adenosine deaminases ADAR-1 and -2 inhibits deaminase activity.
Bavelloni A, Focaccia E, Piazzi M, Raffini M, Cesarini V, Tomaselli S, Orsini A, Ratti S, Faenza I, Cocco L, Gallo A, Blalock WL. | 06/6/2020 |
| ADAR2 binds to double-stranded RNA formed between GA-rich sequences and polypyrimidine-tract and precludes access of U2AF65 to 3' splice site. | Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development.
Tang SJ, Shen H, An O, Hong H, Li J, Song Y, Han J, Tay DJT, Ng VHE, Bellido Molias F, Leong KW, Pitcheshwar P, Yang H, Chen L., Free PMC Article | 05/23/2020 |
| ADARB1 as a genetic etiology in individuals with intellectual disability, microcephaly, and epilepsy. | Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures.
Tan TY, Sedmík J, Fitzgerald MP, Halevy RS, Keegan LP, Helbig I, Basel-Salmon L, Cohen L, Straussberg R, Chung WK, Helal M, Maroofian R, Houlden H, Juusola J, Sadedin S, Pais L, Howell KB, White SM, Christodoulou J, O'Connell MA., Free PMC Article | 05/16/2020 |
| Overexpression of ADAR2, that was incapable of binding to RNA, suppressed growth, motility, and invasion of MPM cells. However, overexpression of ADAR2 that had no enzyme activity did not alter the malignant properties of MPM cells. | ADAR2 Regulates Malignant Behaviour of Mesothelioma Cells Independent of RNA-editing Activity.
Sakata KI, Maeda K, Sakurai N, Liang S, Nakazawa S, Yanagihara K, Kubo T, Yoshiyama H, Kitagawa Y, Hamada JI, Iizasa H. | 04/18/2020 |
| In lung adenocarcinoma, downregulation of ADARB1 was related to shorter first progression (FP), overall survival time (OS) and post-progression survival time (PPS). | Function of low ADARB1 expression in lung adenocarcinoma.
Wang X, Xu Z, Ren X, Chen X, Wei J, Lin W, Li Z, Ou C, Gong Z, Yan Y., Free PMC Article | 03/14/2020 |
| adenosine deaminase acting on RNA 1 (ADAR1) and ADAR2, which catalyze adenosine-to-inosine RNA editing, downregulate the expression of constitutive androstane receptor (CAR) in human liver-derived cells by attenuating splicing | Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver-Derived Cells by Attenuating Splicing.
Nakano M, Fukami T, Nakajima M. | 01/4/2020 |
| Strong downregulation of ADAR2 and increase in ADAR1 expression was observed in blood samples from congenital heart disease (CHD) patients. | Modulation of ADAR mRNA expression in patients with congenital heart defects.
Altaf F, Vesely C, Sheikh AM, Munir R, Shah STA, Tariq A., Free PMC Article | 12/21/2019 |
| The findings illustrate that lipopolysaccharide participates in Hirschsprung's disease through the ADAR2-miR-142-STAU1 axis. | Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis.
Peng L, Zhang H, Su Y, Shen Q, Du C, Xie H, Li H, Yan J, Shen Z, Jiang W, Xia Y, Xu X, Tang W., Free PMC Article | 11/2/2019 |
| Stably introduced into cancer cell lines, the system reports on elevated endogenous ADAR1 editing activity induced by interferon as well as knockdown of ADAR1 and ADAR2. In a single-well setup we used the reporter in HeLa cells to screen a small molecule library of 33 000 compounds | Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries.
Fritzell K, Xu LD, Otrocka M, Andréasson C, Öhman M., Free PMC Article | 08/24/2019 |
| Changes in expression levels of ADAR1 and ADAR2 may represent an important regulatory mechanism in idiopathic pulmonary fibrosis, by regulating the processing of key miRNAs such as miRNA-21. | The Role of ADAR1 and ADAR2 in the Regulation of miRNA-21 in Idiopathic Pulmonary Fibrosis.
Díaz-Piña G, Ordoñez-Razo RM, Montes E, Páramo I, Becerril C, Salgado A, Santibañez-Salgado JA, Maldonado M, Ruiz V. | 06/1/2019 |